Zobrazeno 1 - 10
of 33
pro vyhledávání: '"John B. Mumm"'
Autor:
Ivan H Chan, Dennis Van Hoof, Marina Abramova, Melissa Bilardello, Elliot Mar, Brett Jorgensen, Scott McCauley, Harminder Bal, Martin Oft, Peter Van Vlasselaer, John B Mumm
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0156229 (2016)
Interleukin-10 (IL-10) is a multifunctional cytokine that exerts potent context specific immunostimulatory and immunosuppressive effects. We have investigated the mechanism by which PEGylated rIL-10 regulates plasma cholesterol in mice and humans. In
Externí odkaz:
https://doaj.org/article/15d2efc8347b456ab596f17ca099b999
Autor:
Aung, Naing, Jeffrey R, Infante, Kyriakos P, Papadopoulos, Ivan H, Chan, Cong, Shen, Navneet P, Ratti, Bianca, Rojo, Karen A, Autio, Deborah J, Wong, Manish R, Patel, Patrick A, Ott, Gerald S, Falchook, Shubham, Pant, Annie, Hung, Kara L, Pekarek, Victoria, Wu, Matthew, Adamow, Scott, McCauley, John B, Mumm, Phillip, Wong, Peter, Van Vlasselaer, Joseph, Leveque, Nizar M, Tannir, Martin, Oft
Publikováno v:
Cancer Cell
Tumor-reactive T cell exhaustion prevents the success of immune therapies. Pegilodecakin activates intratumoral CD8(+) T cells in mice and induces objective tumor responses in patients. Here we report that pegilodecakin induces hallmarks of CD8(+) T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1fcc0d797062ef884215cdf4f61fb852
https://pubmed.ncbi.nlm.nih.gov/30423297
https://pubmed.ncbi.nlm.nih.gov/30423297
Autor:
Rakesh Verma, Kyriakos P. Papadopoulos, Peter VanVlasselaer, Nizar M. Tannir, Cong Shen, Scott Alan Mccauley, Ivan H. Chan, Martin Oft, Deborah J. Wong, Gerald S. Falchook, Manish R. Patel, J. Leveque, Karen A. Autio, Jeffrey R. Infante, Matthew Adamow, John B. Mumm, Patrick A. Ott, Aung Naing, Shubham Pant, Phillip Wong, Annie Hung, Navneet Ratti
Publikováno v:
Cancer Immunology Research. 7:A016-A016
Background: Immune therapies rely on successful activation of systemic immunity as well as expansion of the T-cell clones for tumor regression and successful therapeutic outcomes. PEGylated IL-10 (pegilodecakin or AM0010) monotherapy has been reporte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a2cc8a794c956e9761b8b8d4d5990a46
https://doi.org/10.1158/2326-6074.cricimteatiaacr18-a016
https://doi.org/10.1158/2326-6074.cricimteatiaacr18-a016
Autor:
Karen A. Autio, Manish R. Patel, Melinda Whiteside, John B. Mumm, Jeffrey R. Infante, Martin Oft, Todd M. Bauer, Patrick A. Ott, Deborah J. Wong, Nizar M. Tannir, Shubham Pant, Aung Naing, Ivan H. Chan, Peter Van Vlasselaer, Rivka R. Colen, David S. Hong, Johanna C. Bendell, Drew R. Rasco, Kyriakos P. Papadopoulos, Gerald S. Falchook
Publikováno v:
Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 34(29)
Purpose Interleukin-10 (IL-10) stimulates the expansion and cytotoxicity of tumor-infiltrating CD8+ T cells and inhibits inflammatory CD4+ T cells. Pegylation prolongs the serum concentration of IL-10 without changing the immunologic profile. This ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::def14842a5646417300b1cb7a66160da
https://pubmed.ncbi.nlm.nih.gov/27573656
https://pubmed.ncbi.nlm.nih.gov/27573656
Autor:
Gulesi Ayanoglu, Erin Murphy, Scott P. Turner, Amy M Beebe, Ivan H. Chan, John B. Mumm, Venkataraman Sriram, Xueqing Zhang, Catherine Sheppard, Jeff Grein, Beth Basham, Martin Oft, Satya Medicherla, Jan Emmerich, Melanie A. Kleinschek, Lingling Wu, Michael Judo, Steven J. Blaisdell, Terrill K. McClanahan, Susan Cannon-Carlson, John L. Langowski, Danling Gu, Kyu Hong, Wolfgang Seghezzi, Smita Mauze, Brittany C. Paporello, Bela Desai, Saraswathi Naravula, Jie Dai, Drake LaFace, Collette M. Cutler
Publikováno v:
Cancer Cell. 20(6):781-796
Summary Tumor immune surveillance and cancer immunotherapies are thought to depend on the intratumoral infiltration of activated CD8 + T cells. Intratumoral CD8 + T cells are rare and lack activity. IL-10 is thought to contribute to the underlying im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0be7a3a8453fea6fe1ae6913680436ca
Autor:
M Oft, John B. Mumm
Publikováno v:
Oncogene. 27:5913-5919
During the last decade, it has become clear that the mammalian immune system is able to recognize and partially suppress nascent tumors. Human T cells specific to oncogenes and onco-fetal antigens are present in human cancer patients and their tumors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e89b7a0435704b549288b7df200f3b9a
https://doi.org/10.1038/onc.2008.275
https://doi.org/10.1038/onc.2008.275
Publikováno v:
Cytokine. 43:34-44
Restoration of the tumor-suppression function by gene transfer of the melanoma differentiation-associated gene 7 (MDA7)/interleukin 24 (IL-24) successfully induces apoptosis in melanoma tumors in vivo. To address the molecular mechanisms involved, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fcb49073237032968cedae617024784
https://doi.org/10.1016/j.cyto.2008.04.010
https://doi.org/10.1016/j.cyto.2008.04.010
Recent advances in immunoncology have dramatically changed the treatment options available to cancer patients. However, the fundamental challenges with this therapeutic modality are not new and still persist with the current wave of immunoncology com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85aa3951d562a40f001b6c91822b3c00
https://europepmc.org/articles/PMC4675350/
https://europepmc.org/articles/PMC4675350/
Autor:
Rajagopal Ramesh, Abner M. Mhashilkar, Sunil Chada, John B. Mumm, Mingzhong Zheng, Elizabeth A. Grimm, Dora Bocangel
Publikováno v:
Molecular Therapy. 11(5):724-733
The melanoma differentiation-associated gene (mda-7; approved gene symbol IL24) is a tumor suppressor gene whose protein expression in normal cells is restricted to the immune system and to melanocytes. Recent studies have shown that mda-7 gene trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44b960399185f8ef5f2b3e465db64174
Autor:
John B. Mumm, Mingzhong Zheng, Dora Bocangel, Elizabeth A. Grimm, Abner M. Mhashilkar, R. Bryan Sutton, Suhendan Ekmekcioglu, Rajagopal Ramesh, Sunil Chada
Publikováno v:
Molecular Therapy. 10:1085-1095
The melanoma differentiation-associated gene-7 (mda-7/IL24) is a unique member of the IL-10 family of cytokines, with ubiquitous tumor cell proapoptotic activity. Transduction of tumor or normal cells with the mda-7 gene results in secretion of glyco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e16c070130ae486066faf3f6433a5727
https://doi.org/10.1016/j.ymthe.2004.08.020
https://doi.org/10.1016/j.ymthe.2004.08.020