Zobrazeno 1 - 10
of 19
pro vyhledávání: '"John B. McArthur"'
Autor:
Xiaohong Yang, Xiaoxiao Yang, Hai Yu, Lan Na, Tamashree Ghosh, John B. McArthur, Tsui-Fen Chou, Patricia Dickson, Xi Chen
Publikováno v:
AMB Express, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Carbohydrate-Active enZYme (CAZY) GH89 family enzymes catalyze the cleavage of terminal α-N-acetylglucosamine from glycans and glycoconjugates. Although structurally and mechanistically similar to the human lysosomal α-N-acetylglucosaminid
Externí odkaz:
https://doaj.org/article/94edb55b8e124834b4a703229044f87a
Publikováno v:
Metabolic Engineering. 66:12-20
Human milk oligosaccharides (HMOs) are potent bioactive compounds that modulate neonatal health and are of interest for development as potential drug treatments for adult diseases. The potential of these molecules, their limited access from natural s
Autor:
Xiaoxiao Yang, John B. McArthur, Xi Chen, Xiaohong Yang, Hai Yu, Patricia I. Dickson, Lan Na, Tsui-Fen Chou, Tamashree Ghosh
Publikováno v:
AMB Express, Vol 11, Iss 1, Pp 1-12 (2021)
AMB Express, vol 11, iss 1
AMB Express
AMB Express, vol 11, iss 1
AMB Express
Carbohydrate-Active enZYme (CAZY) GH89 family enzymes catalyze the cleavage of terminal α-N-acetylglucosamine from glycans and glycoconjugates. Although structurally and mechanistically similar to the human lysosomal α-N-acetylglucosaminidase (hNAG
Publikováno v:
ACS catalysis, vol 10, iss 11
ACS Catal
ACS Catal
Pasteurella multocida heparosan synthase 2 (PmHS2) is a dual-function polysaccharide synthase having both α1–4-N-acetylglucosaminyltransferase (α1–4-GlcNAcT) and β1–4-glucuronyltransferase (β1–4-GlcAT) activities located in two separate c
Publikováno v:
ACS catalysis, vol 9, iss 12
ACS Catal
ACS Catal
β1-3-Linked galactosides such as Galβ1‒3GlcNAcβOR are common carbohydrate motifs found in human milk oligosaccharides (HMOSs), glycolipids, and glycoproteins. Efficient and scalable enzymatic syntheses of these structures have proven challenging
Publikováno v:
Carbohydrate Research. 472:86-97
Carbohydrates are structurally complex but functionally important biomolecules. Therefore, they have been challenging but attractive synthetic targets. While substantial progress has been made on advancing chemical glycosylation methods, incorporatin
Publikováno v:
Biochemistry, vol 59, iss 34
Biochemistry
Biochemistry
Cytidine 5'-monophosphate (CMP)-sialic acid synthetase (CSS) is an essential enzyme involved in the biosynthesis of carbohydrates and glycoconjugates containing sialic acids, a class of α-keto acids that are generally terminal key recognition residu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::364c500e9eadd566cbd4459674502919
https://escholarship.org/uc/item/3fx0x23d
https://escholarship.org/uc/item/3fx0x23d
Autor:
Anoopjit Singh Kooner, Hai Yu, John B. McArthur, Wanqing Li, Ziqi Liu, Xi Chen, Abhishek Santra
Publikováno v:
Organic & biomolecular chemistry, vol 18, iss 4
Org Biomol Chem
Org Biomol Chem
5,7-Di-N-acetyllegionaminic acid (Leg5,7Ac(2)) is a bacterial nonulosonic acid (NulO) analogue of sialic acids, an important class of monosaccharides in mammals and in some bacteria. To develop efficient one-pot multienzyme (OPME) glycosylation syste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b222cfe014a4ee693b43d79c98aee83d
https://escholarship.org/uc/item/92c5z8b5
https://escholarship.org/uc/item/92c5z8b5
Autor:
Abhishek Santra, An Xiao, Hai Yu, Wanqing Li, Yanhong Li, Linh Ngo, John B. McArthur, Xi Chen
Publikováno v:
Angewandte Chemie International Edition. 57:2929-2933
A chemoenzymatic synthon was designed to expand the scope of the chemoenzymatic synthesis of carbohydrates. The synthon was enzymatically converted into carbohydrate analogues, which were readily derivatized chemically to produce the desired targets.
Autor:
John B. McArthur, Stephanie Grond, Tilmann Weber, Thomas Schafhauser, Gavin J. Williams, Thomas Härtner, Wolfgang Wohlleben, Florian Zubeil, Sang Yup Lee, Ewa M. Musiol-Kroll, Irina Koryakina, Andreas Kulik
Publikováno v:
ACS Synthetic Biology. 6:421-427
During polyketide biosynthesis, acyltransferases (ATs) are the essential gatekeepers which provide the assembly lines with precursors and thus contribute greatly to structural diversity. Previously, we demonstrated that the discrete AT KirCII from th