Zobrazeno 1 - 9
of 9
pro vyhledávání: '"John B. Leppard"'
Autor:
Munehisa Yabuki, W Jason Cummings, John B Leppard, Robert M Immormino, Christi L Wood, Daniel S Allison, Patrick W Gray, Larry W Tjoelker, Nancy Maizels
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e36032 (2012)
Monoclonal antibodies (mAbs) can be potent and highly specific therapeutics, diagnostics and research reagents. Nonetheless, mAb discovery using current in vivo or in vitro approaches can be costly and time-consuming, with no guarantee of success. We
Externí odkaz:
https://doaj.org/article/a23b053ae13444a0a46f729efdb2b925
Autor:
Tapas K. Hazra, Padmini S. Kedar, Sankar Mitra, Huxian Wang, Istvan Boldogh, Rajendra Prasad, Michael Weinfeld, Samuel H. Wilson, Lee R Wiederhold, Feridoun Karimi-Busheri, John B. Leppard, Alan E. Tomkinson, Aditi Das
Publikováno v:
DNA Repair. 5:1439-1448
DNA glycosylases/AP lyases initiate repair of oxidized bases in the genomes of all organisms by excising these lesions and then cleaving the DNA strand at the resulting abasic (AP) sites and generate 3' phospho alpha,beta-unsaturated aldehyde (3' PUA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e89ab4177241578e54039ebef7279f34
https://doi.org/10.1016/j.dnarep.2006.07.003
https://doi.org/10.1016/j.dnarep.2006.07.003
Autor:
John B. Leppard, James J. Champoux
Publikováno v:
Chromosoma. 114:75-85
Human DNA topoisomerase I is an essential enzyme involved in resolving the torsional stress associated with DNA replication, transcription, and chromatin condensation. The catalytic cycle of the enzyme consists of DNA cleavage to form a covalent enzy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11e6a347164ee71f16930294559bbbe1
https://doi.org/10.1007/s00412-005-0345-5
https://doi.org/10.1007/s00412-005-0345-5
Autor:
Jingwen Chen, Zachary B. Mackey, Claude Niedergang, Gilbert de Murcia, Alan E. Tomkinson, Josiane Ménissier-de Murcia, Karin Au, John B. Leppard
Publikováno v:
Journal of Biological Chemistry. 274:21679-21687
Mammalian DNA ligases are composed of a conserved catalytic domain flanked by unrelated sequences. At the C-terminal end of the catalytic domain, there is a 16-amino acid sequence, known as the conserved peptide, whose role in the ligation reaction i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9092dff45089faae0e643274a4f06aa9
https://doi.org/10.1074/jbc.274.31.21679
https://doi.org/10.1074/jbc.274.31.21679
Autor:
Patrick W. Gray, Daniel S. Allison, W. Jason Cummings, Christi L. Wood, Munehisa Yabuki, Larry W. Tjoelker, Robert M. Immormino, John B. Leppard, Nancy Maizels
Publikováno v:
PLoS ONE
PLoS ONE, Vol 7, Iss 4, p e36032 (2012)
PLoS ONE, Vol 7, Iss 4, p e36032 (2012)
Monoclonal antibodies (mAbs) can be potent and highly specific therapeutics, diagnostics and research reagents. Nonetheless, mAb discovery using current in vivo or in vitro approaches can be costly and time-consuming, with no guarantee of success. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ec02af71e27cc101c3c440932347534
https://pubmed.ncbi.nlm.nih.gov/22558313
https://pubmed.ncbi.nlm.nih.gov/22558313
Autor:
James J. Champoux, Heidrun Interthal, Jörg Zotzmann, Thomas E. Kehl-Fie, John B. Leppard, Hong Jing Chen
Publikováno v:
The EMBO journal. 24(12)
Tyrosyl-DNA phosphodiesterase (Tdp1) catalyzes the hydrolysis of the tyrosyl-3' phosphate linkage found in topoisomerase I-DNA covalent complexes. The inherited disorder, spinocerebellar ataxia with axonal neuropathy (SCAN1), is caused by a H493R mut
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dee03f1e378e000b9300436fcabb00e0
https://pubmed.ncbi.nlm.nih.gov/15920477
https://pubmed.ncbi.nlm.nih.gov/15920477
Publikováno v:
Molecular and cellular biology. 23(16)
The repair of DNA single-strand breaks in mammalian cells is mediated by poly(ADP-ribose) polymerase 1 (PARP-1), DNA ligase IIIalpha, and XRCC1. Since these proteins are not found in lower eukaryotes, this DNA repair pathway plays a unique role in ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dffe28897adea5b202632aff6ed7d0a
https://pubmed.ncbi.nlm.nih.gov/12897160
https://pubmed.ncbi.nlm.nih.gov/12897160
Autor:
Alan E. Tomkinson, Ling Chen, John B. Leppard, Teresa A. Motycka, Zhiwan Dong, David S. Levin, Zachary B. Mackey
Three mammalian genes encoding DNA ligases--LIG1, LIG3, and LIG4--have been identified. Genetic, biochemical, and cell biology studies indicate that the products of each of these genes play a unique role in mammalian DNA metabolism. Interestingly, ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::696026a388579858407eeb152c9e9e6c
https://doi.org/10.1016/s0079-6603(01)68097-8
https://doi.org/10.1016/s0079-6603(01)68097-8
