Zobrazeno 1 - 4
of 4
pro vyhledávání: '"John B. Le Gall"'
Autor:
Yun Ji, Jessica Fioravanti, Wei Zhu, Hongjun Wang, Tuoqi Wu, Jinhui Hu, Neal E. Lacey, Sanjivan Gautam, John B. Le Gall, Xia Yang, James D. Hocker, Thelma M. Escobar, Shan He, Stefania Dell’Orso, Nga V. Hawk, Veena Kapoor, William G. Telford, Luciano Di Croce, Stefan A. Muljo, Yi Zhang, Vittorio Sartorelli, Luca Gattinoni
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
The inability of T cells to properly mount anti-tumour immunity underlies failed cancer immune surveillance or therapy. Here the authors show that a microRNA, miR-155, suppresses Ship1 phosphatase expression to modulate epigenetic reprogramming of CD
Externí odkaz:
https://doaj.org/article/f7106871939f484092d79cd389893db3
Autor:
Nicholas P. Restifo, Luca Gattinoni, Rahul Roychoudhuri, Timothy P. Bender, Avinash Bhandoola, Philip Brohawn, Veena Kapoor, Wei Zhu, John B. Le Gall, Sanjivan Gautam, Brandon W. Higgs, Devikala Gurusamy, Zhiya Yu, Yun Ji, James D. Hocker, Nga V. Hawk, Neal E. Lacey, Jessica Fioravanti, Jinhui Hu, William G. Telford, Hai-Hui Xue
Publikováno v:
Nature immunology
Stem cells are maintained by transcriptional programs that promote self-renewal and repress differentiation. Here, we found that the transcription factor c-Myb was essential for generating and maintaining stem cells in the CD8+ T cell memory compartm
Autor:
Elizabeth M. Kang, Thomas E. Hughes, Kristina M Brooks, Parag Kumar, Paul Jarosinski, John B. Le Gall, Nirali N. Shah, Suk See De Ravin, Jomy M. George, Dennis D. Hickstein
Publikováno v:
Journal of clinical pharmacology. 58(3)
Intravenous (IV) busulfan test dose pharmacokinetics (PK) has been shown to accurately predict once-daily dose requirements and improve outcomes in adult transplant patients, but there are limited data to support this approach in children. Test doses
Autor:
Jinhui Hu, Wei Zhu, Stefan A. Muljo, Xia Yang, Tuoqi Wu, Nga V. Hawk, John B. Le Gall, Yi Zhang, James D. Hocker, Luciano Di Croce, Vittorio Sartorelli, Stefania Dell'Orso, Neal E. Lacey, Thelma M. Escobar, Veena Kapoor, Hong Jun Wang, William G. Telford, Jessica Fioravanti, Yun Ji, Luca Gattinoni, Shan He, Sanjivan Gautam
Publikováno v:
Recercat. Dipósit de la Recerca de Catalunya
instname
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Nature Communications
instname
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Nature Communications
T cell senescence and exhaustion are major barriers to successful cancer immunotherapy. Here we show that miR-155 increases CD8+ T cell antitumor function by restraining T cell senescence and functional exhaustion through epigenetic silencing of driv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2cfc39283945bbce8452afc7cde8300
http://hdl.handle.net/10230/42200
http://hdl.handle.net/10230/42200