Zobrazeno 1 - 10
of 12
pro vyhledávání: '"John B. Kurek"'
Autor:
Edward Byrne, John B. Kurek, Lawrence Austin, Timothy M. Bennett, Sandra J Feeney, M. J. Bernadette Jean-François, CM Muldoon
Publikováno v:
Cytokine. 23:108-118
Before potential therapeutic strategies for the treatment of amyotrophic lateral sclerosis (ALS) can be advanced to human clinical trials, there is a need to assess them in an animal model that best resembles the disease process. SOD1 G93A mice have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82dc3b19c12d519e8ce7315d7b3caf7e
https://doi.org/10.1016/s1043-4666(03)00217-5
https://doi.org/10.1016/s1043-4666(03)00217-5
Publikováno v:
Brain Research. 922:144-147
Leukemia inhibitory factor (LIF) is a survival factor for motoneurons. In this study we investigated whether intense systemic LIF therapy prevents the loss of lumbar motoneurons in the transgenic SOD1 G93A mouse model of familial amyotrophic lateral
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::932451cac56cf284ad9c8bcc591832df
https://doi.org/10.1016/s0006-8993(01)03156-0
https://doi.org/10.1016/s0006-8993(01)03156-0
Publikováno v:
Muscle & Nerve. 19:1291-1301
The process of skeletal muscle regeneration following injury or disease involves locally produced growth factors which control cellular proliferation and differentiation. Leukemia inhibitory factor (LIF) and interleukin-6 (IL-6) have previously been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e66b8ec0d2ff39aac92cc45d8eef133
https://doi.org/10.1002/(sici)1097-4598(199610)19:10<1291::aid-mus6>3.0.co
https://doi.org/10.1002/(sici)1097-4598(199610)19:10<1291::aid-mus6>3.0.co
Publikováno v:
Neuromuscular Disorders. 6:105-114
Leukaemia inhibitory factor (LIF) and Interleukin-6 (IL-6) are multifunctional cytokines that are related on the basis of their predicted structural similarities and shared signal transducing receptor components. Both these factors stimulate myoblast
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9e0174a52e749a7ab6d17d236923a4f
https://doi.org/10.1016/0960-8966(95)00029-1
https://doi.org/10.1016/0960-8966(95)00029-1
Autor:
Scott D. Freer, Wei Bu, Philip L. Stetson, Daniel W. Sved, John B. Kurek, Robert A. Boyd, Shelly Hollar
Publikováno v:
Rapid communications in mass spectrometry : RCM. 17(21)
A liquid chromatography/mass spectrometry (LC/MS) analytical procedure, using a single column for sample clean-up, enrichment and separation, has been developed for the determination of the peptide AM336 in monkey cerebrospinal fluid (CSF). CSF sampl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd29fac6982664d42b1f7d4801e493c3
https://pubmed.ncbi.nlm.nih.gov/14587085
https://pubmed.ncbi.nlm.nih.gov/14587085
Publikováno v:
Cancer chemotherapy and pharmacology. 48(6)
Purpose: Peripheral neuropathy caused by the anticancer agents cisplatin and paclitaxel is a significant dose-limiting toxicity of these drugs. The growth factor leukaemia inhibitory factor (LIF) has neuroprotectant activity in preclinical models of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb7f8fc67d1beb447c17568dad77f397
https://pubmed.ncbi.nlm.nih.gov/11800022
https://pubmed.ncbi.nlm.nih.gov/11800022
Publikováno v:
Musclenerve. 24(5)
Cell-based therapies, such as myoblast transfer therapy, are likely to become an integral part of any approach to treat myopathies such as Duchenne muscular dystrophy. Previous studies have shown that an increased level of regeneration in the host mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8300da3c62e91b5f1f352030c04f52d8
https://pubmed.ncbi.nlm.nih.gov/11317281
https://pubmed.ncbi.nlm.nih.gov/11317281
Autor:
John B. Kurek, Sandra J Feeney, John J. Bower, Lawrence Austin, David E Crump, Anthony J Radford, Edward Byrne
Publikováno v:
Journal of the neurological sciences. 160
Growth factors are theoretically promising agents for ALS therapy, but have been disappointing in subcutaneous delivery due to either toxicity or lack of major efficacy. Leukaemia inhibitory factor (LIF), was named after its effect on haemopoietic ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4abff610dda00a5f14a78acd7e1ca2fd
https://pubmed.ncbi.nlm.nih.gov/9851659
https://pubmed.ncbi.nlm.nih.gov/9851659
Publikováno v:
Neuroscience letters. 249(1)
A model of spinal trauma was developed where spinal neurones of adult mice were exposed to the excitotoxic glutamate analogue β - N -oxylamino- l -alanine ( l -BOAA). After 24 h, the injured neurones received a single dose of [ 125 I]-LIF at the sam
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68fa77a80474436831faab0ce19524d8
https://pubmed.ncbi.nlm.nih.gov/9672374
https://pubmed.ncbi.nlm.nih.gov/9672374
Autor:
John B. Kurek, John J. Bower, Mark Murphy, Margarita Romanella, Frank Koentgen, Lawrence Austin
Publikováno v:
Musclenerve. 20(7)
Although a number of cytokines have been implicated in tissue regeneration, it is unknown which ones actually function in vivo. Here, we use mice with a targeted mutation in the leukemia inhibitory factor (LIF) gene to examine the role of LIF in musc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46b94607eb591273f6a3d515ecc2dfbb
https://pubmed.ncbi.nlm.nih.gov/9179153
https://pubmed.ncbi.nlm.nih.gov/9179153