Výsledky vyhledávání - "John B. J. Pavey"

Synthesis and transcription studies on 5′-triphosphates derived from 2′-C-branched-uridines: 2′-homouridine-5′-triphosphate is a substrate for T7 RNA polymerase

Autor: Richard Cosstick, Stefan Vortler, John B. J. Pavey, Anthony J. Lawrence, Ian A. O'Neil

Publikováno v: Org. Biomol. Chem.. 2:869-875

The 5'-triphosphates of 2'-hydroxymethyluridine (2'-homouridine) and 2'-hydroxyethyluridine were prepared from the corresponding acetyl-protected nucleosides by initial phosphitylation with 2-chloro-5,6-benzo-1,2,3-dioxaphosphorin-4-one. 2'-Acetamido

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c81b392830a269a6965eec173a103a89
https://doi.org/10.1039/b314348a

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The synthesis of 2′-homouridine, its incorporation into a dinucleoside monophosphate and hydrolytic behaviour of the dimer

Autor: John B. J. Pavey, Richard Cosstick, Ian A. O'Neil, Andrew J. Potter, Anthony J. Lawrence

Publikováno v: Tetrahedron Letters. 39:6967-6970

An efficient route to 2′-homouridine ( 1 ), a new nucleoside analogue, is reported that is based on an ene reaction. This nucleoside has been incorporated into a dinucleoside monophosphate and hydrolytic studies on the dimer show that it does not b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::261177661f62c7af295a8c7ddee46b28
https://doi.org/10.1016/s0040-4039(98)01478-6

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Total synthesis of the protein phosphatase inhibitor okadaic acid

Autor: Holger Eick, Alexander C. Humphries, Andrew R. Ross, John B. J. Pavey, Richard J. Boyce, Steven V. Ley, Jörg Pietruszka, Robert Downham

Publikováno v: Journal of the Chemical Society, Perkin Transactions 1. :3907-3912

The total synthesis of the protein phosphatase inhibitor okadaic acid 1 is reported using a convergent coupling strategy of three components, all of which may be prepared using chemistry developed in our laboratories.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5381520bc108a003428375c58ea4bd6f
https://doi.org/10.1039/a807957i

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The Synthesis of 2′-C-Functionalised Nucleosides for Incorporation into Catalytic RNA

Autor: John B. J. Pavey, Richard Cosstick, Ian A. O'Neil, Anthony J. Lawrence

Publikováno v: Nucleosides and Nucleotides. 16:1497-1501

Five 2′-C-functionalized nucleosides (1–5) have been prepared and incorporated into dinucleoside monophosphates. The effect of the functionality on the stability of the adjacent phosphodiester bond toward hydrolysis by nuclease enzymes and extrem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::22569388ab97048b297c0b8e4770251b
https://doi.org/10.1080/07328319708006215

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Synthesis, structure and reactions of uridine 2′-C,3′-O-γ-butyrolactone: versatile intermediate for the synthesis of 2′-C-branched nucleosides

Autor: Julie Fisher, Mai-Yee Chan, Stephen Paul Collingwood, Robin Alec Fairhurst, John B. J. Pavey, Richard Cosstick, Anthony J. Lawrence, Ian A. O'Neil

Publikováno v: Journal of the Chemical Society, Perkin Transactions 1. :2761-2768

Uridine 2′-C-3′-O-γ-butyrolactone 5a has been prepared by cyclisation of 2′-α-C-carboxymethyl-2′-deoxyuridine 8 in acetic acid–methanol. Detailed 1H NMR studies on compound 5a clearly demonstrate cis fusion between the γ-lactone and the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dfff353eba09f0a3964a57752764cb23
https://doi.org/10.1039/a702088k

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Synthesis and Properties of 2‘-Deoxy-2‘-α-C-branched Nucleosides and Nucleotides

Autor: Anthony J. Lawrence, John B. J. Pavey, Ian A. O'Neil, Richard Cosstick

Publikováno v: The Journal of Organic Chemistry. 61:9213-9222

Four functionalized 2‘-deoxy-2‘-α-C-branched nucleosides, namely, 2‘-deoxy-2‘-α-C-(carboxymethyl)uridine, 2‘-deoxy-2‘-α-C-acetamidouridine, 2‘-deoxy-2‘-α-C-(hydroxyethyl)uridine, and 2‘-deoxy-2‘-α-...

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::05b9eab76253720d37bf31bc90e389f3
https://doi.org/10.1021/jo9614607

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ChemInform Abstract: Synthesis and Properties of 2′-Deoxy-2′-α-C-branched Nucleosides and Nucleotides

Autor: Ian A. O'Neil, Richard Cosstick, John B. J. Pavey, Anthony J. Lawrence

Publikováno v: ChemInform. 28

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d0617d2350ca8da2157c09e5101c2292
https://doi.org/10.1002/chin.199719238

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