Zobrazeno 1 - 10
of 91
pro vyhledávání: '"John B. Hays"'
Autor:
Andrew R. Blaustein, Thea F van de Mortel, John B. Hays, Peter D. Hoffman, William A. Buttemer
Publikováno v:
Oecologia. 115(3)
Ultraviolet-B (UV-B) irradiation of DNA generates mutagenic photoproducts such as cyclobutane pyrimidine dimers (CPDs) which can affect the growth and development of amphibian embryos. Differential ability to repair UV-B-induced DNA damage may be␣r
Autor:
Marc J. Curtis, John B. Hays
Publikováno v:
DNA Repair. 10:1272-1281
Conserved DNA-damage responses (DDRs) efficiently cope with replication blocks and double-strand breaks (DSBs) in cultured eukaryotic cells; DDRs in tissues remain poorly understood. DDR-inactivating mutations lethal in animals are tolerated in Arabi
Publikováno v:
Theoretical and Applied Genetics. 123:1445-1458
In plant breeding, the ability to manipulate genetic (meiotic) recombination would be beneficial for facilitating gene transfer from wild relatives of crop plants. The DNA mismatch repair (MMR) system helps maintain genetic integrity by correcting ba
Autor:
John B. Hays
Publikováno v:
DNA Repair. 10:526-535
Two proteins that process damaged DNA may function in the same pathway, or in redundant ("synergistic") pathways that respond to the same lesion(s), or in parallel pathways targeted to different lesions. Previously, extended plots of positive outcome
Autor:
Y.H. Duong, Tomoyuki Furukawa, D. Aggoune, Colin M. Tominey, Anne B. Britt, Marc J. Curtis, B.W.L. Wilcox, John B. Hays
Publikováno v:
DNA Repair. 9:940-948
Both UVB radiation and DNA-breaking agents were previously reported to kill Arabidopsis stem cells. We demonstrate that death induced by UVB or by ionizing radiation (IR) requires Suppressor of Gamma Response 1 (SOG1), a transcription factor already
Publikováno v:
Biochemistry. 47:4583-4596
To assess how evolution might have biochemically shaped DNA polymerase eta (Poleta) in plants, we expressed in Escherichia coli proteins from Arabidopsis thaliana (At), humans (Hs), and the yeast Saccharomyces cerevisiae (Sc), purified them to near h
Autor:
John B. Hays, Marc J. Curtis
Publikováno v:
DNA Repair. 6:1341-1358
In tissues of multicellular organisms, DNA lesions that block replication can disrupt division of the transiently amplifying (TA) cells and stem cells that drive growth. To study how tissue growth is maintained despite DNA damage, stem cells and othe
Autor:
Phillip C. Hanawalt, Thomas Lindahl, Errol C. Friedberg, Richard D. Wood, Alan R. Lehmann, Martin Gellert, Noel F. Lowndes, Andrés Aguilera, John B. Hays, Alain Sarasin
Publikováno v:
DNA Repair. 5:986-996
A comprehensive meeting on biological responses to DNA damage organized by Alan Lehmann, Deborah Barnes, Wouter Ferro, Robert Fuchs, Jan Hoeijmakers, Roland Kanaar, Leon Mullenders and Bert van Zeeland, was convened at Noordwijkerhout, The Netherland
Publikováno v:
Environmental and Molecular Mutagenesis. 47:296-306
Mismatch-repair (MMR) systems correct DNA replication errors and respond to a variety of DNA lesions. Previous observations that MMR antagonizes UV mutagenesis, and that the mismatch-recognition protein heterodimer MSH2•MSH6 (MutSα) selectively bi
Publikováno v:
DNA Repair. 4:1463-1474
Evolutionarily-conserved mismatch-repair (MMR) systems correct all or almost all base-mismatch errors from DNA replication via excision-resynthesis pathways, and respond to many different DNA lesions. Consideration of DNA polymerase error rates and p