Zobrazeno 1 - 10
of 11
pro vyhledávání: '"John B. Etienne"'
Autor:
John B. Etienne, James W. Thackeray, James F. Cameron, P. J. Thomas, Duane R. Romer, Vipul Jain, Matthias S. Ober
Publikováno v:
Macromolecules. 52:886-895
A new class of acid labile poly(aryl acetal) polymers has been developed that can be used in photoresist formulations for next-generation microlithography techniques including extreme ultraviolet (EUV) or electron beam lithography. Example polymers h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d17c761d315b5d0fc7413423ac51fd9
https://doi.org/10.1021/acs.macromol.8b01038
https://doi.org/10.1021/acs.macromol.8b01038
Autor:
Michael Scott Visser, Michael P. DeNinno, Melissa P. Andrews, Andrew Simon Bell, Michael John Palmer, Nan Eshelby, Cynthia Eller-Zarbo, John B. Etienne, Yue Chen, E. Michael Gibbs, William J. Zavadoski, Li J. Yu, Dianna E. Moore
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:2537-2541
Starting from a non-selective pyrazolo-pyrimidone lead, the sequential use of parallel medicinal chemistry and directed synthesis led to the discovery of potent, highly selective, and orally bioavailable PDE9 inhibitors. The availability of these too
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90579384bdc00653d5f3b8ed65d6fc3e
https://doi.org/10.1016/j.bmcl.2009.03.024
https://doi.org/10.1016/j.bmcl.2009.03.024
Autor:
Charles E. Chandler, Michael P. Zawistoski, R.W. Wilkins, Heidi A. Woody, Michael P. DeNinno, Eliot Sugarman, John B. Etienne, Cynthia Eller, Kimberly C. Duplantier, Mccarthy Peter A, Lawrence M. Zaccaro, F.W. Bangerter, Lee A. Morehouse
Publikováno v:
Journal of Medicinal Chemistry. 40:2547-2554
We have explored the use of steroidal glycosides as cholesterol absorption inhibitors which act through an unknown mechanism. The lead for this program was tigogenin cellobioside (1, tiqueside) which is a weak inhibitor (ED50 = 60 mg/kg) as measured
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8bf6347bb2d2ceba68223277c4f5158
https://doi.org/10.1021/jm9702600
https://doi.org/10.1021/jm9702600
Autor:
Melissa P. Andrews, Michael P. DeNinno, Stephen W. Wright, John B. Etienne, Karen L. Houseknecht, Dianna E. Moore, David D. Boyer, Shawn D. Doran, Michele L. Millham, Benjamin N. Rocke, Thanh V. Olson, Cynthia Zarbo, Brian P. Boscoe, Michael Scott Visser
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(10)
The first highly potent and selective PDE8 inhibitors are disclosed. The initial tetrahydroisoquinoline hit was transformed into a nipecotic amide series in order to address a reactive metabolite issue. Reduction of lipophilicity to address metabolic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::726dc1f46e629cda90dac833fe1d4f08
https://pubmed.ncbi.nlm.nih.gov/21459572
https://pubmed.ncbi.nlm.nih.gov/21459572
Publikováno v:
ChemInform. 26
Glucose-derived 4,6-O-benzylidene acetals can be selectively reduced to the corresponding 6-O-benzyl derivatives by the treatment with trifluoroacetic acid and triethylsilane.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2da055660630cfe3b32c253c934c85ee
https://doi.org/10.1002/chin.199523202
https://doi.org/10.1002/chin.199523202
Publikováno v:
ChemInform. 33
Intramolecular endo-cyclization reactions of N-acyliminium ions have seen wide application for the synthesis of heterocyclic compounds. The corresponding exocyclic variant, which would provide 1-aminotetralin derivatives, for example, has little prec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::62860e879550284d171be2758e51ea2c
https://doi.org/10.1002/chin.200210048
https://doi.org/10.1002/chin.200210048
Autor:
John B. Etienne, Michael P. DeNinno, Scott P. Kennedy, Jimmy Kong, Roger J. Hill, Hiroko Masamune, Kenneth J. DiRico, Cynthia Eller, W. Ross Tracey, Jeanene E. Tickner, Joseph J. Oleynek, Delvin R. Knight, Lois K. Chenard
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(9)
Using a combination of parallel and directed synthesis, the discovery of a highly potent and selective series of adenosine A3 agonists was achieved. High aqueous solubility, required for the intended parenteral route of administration, was achieved b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad564239b2f7c1c057babe0e7df9a8c9
https://pubmed.ncbi.nlm.nih.gov/16464581
https://pubmed.ncbi.nlm.nih.gov/16464581
Autor:
John P. O'Donnell, Walinsky Stanley W, R.W. Wilkins, Mccarthy Peter A, Michael P. Zawistoski, Kimberly C. Duplantier, Lee A. Morehouse, Charles E. Chandler, Theresa C. Wilson, F.W. Bangerter, Susan L. Pezzullo, John B. Etienne, Lambert John F, Watson Harry A, Frank J. Urban, Michael P. DeNinno, Patricia G. Cosgrove, Michael A. Fowler, Lawrence M. Zaccaro
Publikováno v:
Journal of Medicinal Chemistry. 39:1935-1937
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b67dc0168fe43f33e1c1cc90dfabd323
https://doi.org/10.1021/jm960123n
https://doi.org/10.1021/jm960123n
Autor:
Michael P. DeNinno, John B. Etienne, Jeanene E. Tickner, Kenneth J. DiRico, W. Ross Tracey, Roger J. Hill, Scott P. Kennedy, Jimmy Kong, Lois K. Chenard, Cynthia Eller, Hiroko Masamune, Joseph J. Oleynek, Delvin R. Knight
Publikováno v:
Journal of medicinal chemistry. 46(3)
Selective adenosine A(3) agonists have potential utility for the prevention of perioperative myocardial ischemic injury. Herein, we report on the discovery and synthesis of compound 7. This amino nucleoside agonist possesses unprecedented levels of s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97fe97d36c3f1729a7fcc3618cbf2430
https://pubmed.ncbi.nlm.nih.gov/12540233
https://pubmed.ncbi.nlm.nih.gov/12540233
Publikováno v:
The Journal of organic chemistry. 66(21)
Intramolecular endo-cyclization reactions of N-acyliminium ions have seen wide application for the synthesis of heterocyclic compounds. The corresponding exocyclic variant, which would provide 1-aminotetralin derivatives, for example, has little prec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a766a9f1faf489985e3dec2e36d5fd1
https://pubmed.ncbi.nlm.nih.gov/11597218
https://pubmed.ncbi.nlm.nih.gov/11597218