Zobrazeno 1 - 10
of 13
pro vyhledávání: '"John B. Beard"'
Publikováno v:
Cancer Research. 80:6450-6450
Hepsin, a type II transmembrane serine protease, is commonly overexpressed in a variety of epithelial cancers, where its overexpression and concurrent proteolytic activity correlate with tumor progression. Recent studies indicate that Hepsin undergoe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2155eec8bb44348a2e1ef5fd21cd0718
https://doi.org/10.1158/1538-7445.am2020-6450
https://doi.org/10.1158/1538-7445.am2020-6450
Autor:
Timothy J. O'Brien, John B. Beard
Publikováno v:
Extracellular Targeting of Cell Signaling in Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::76f9df37c71a5e8301d7141425935d64
https://doi.org/10.1002/9781119300229.ch13
https://doi.org/10.1002/9781119300229.ch13
Publikováno v:
Tumor Biology. 30:51-60
Background: CA 125 antigenic domains appear to reside within a region containing 156-amino acid sequence repeats. Surprisingly, anti-CA 125 antibodies can be classified into three f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::40574684a521bf7e95b7d4fa5ec45655
https://doi.org/10.1159/000209988
https://doi.org/10.1159/000209988
Autor:
Xiurong Tian, Takashi Sawasaki, Kazushi Shigemasa, Timothy J. O'Brien, Lijun Gu, Hirotoshi Tanimoto, John B. Beard
Publikováno v:
British Journal of Cancer
Tumour-associated differentially expressed gene-15 (TADG-15/ST14/matriptase/MT-SP1) is a novel member of the transmembrane serine proteases. Previous studies indicated that TADG-15 is overexpressed in ovarian tumours; however, relationships between e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3b311daff191b689f52c4037f426451
https://doi.org/10.1038/sj.bjc.6602320
https://doi.org/10.1038/sj.bjc.6602320
Autor:
Timothy J. O'Brien, John B. Beard, Lowell J. Underwood, Alessandro D. Santin, Lyndal York, Richard A. Dennis
Publikováno v:
Tumor Biology. 22:348-366
CA 125 has long presented problems to both clinicians and investigators because there was no definitive information on its structure and function. Here, we describe our work on cloning the CA 125 gene with the anticipation that such information will
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::198a4076ca91f72556676d0b10b4e785
https://doi.org/10.1159/000050638
https://doi.org/10.1159/000050638
Autor:
Timothy J. O'Brien, Kazushi Shigemasa, Lowell J. Underwood, Hirotoshi Tanimoto, Tim H. Parmley, Koso Ohama, John B. Beard
Publikováno v:
Journal of the Society for Gynecologic Investigation. 7:358-362
Objective:In a continued effort to identify and characterized secreted proteases that are overexpressed in ovarian carcinomas, we discovered the testisin protease as such a candidate. When this dis...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2bfedcc3043727a894baf956556ea720
https://doi.org/10.1177/107155760000700608
https://doi.org/10.1177/107155760000700608
Publikováno v:
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 25(3)
The purpose of this study was to examine the expression of splice variants of the TADG-12 (TMPRSS3) gene in normal ovarian epithelial tissue and ovarian carcinoma and further to associate the expression of TADG-12 variant with clinicopathologic chara
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a819fcf9672bc36f807a299ec6e1b1e
https://pubmed.ncbi.nlm.nih.gov/15361711
https://pubmed.ncbi.nlm.nih.gov/15361711
Publikováno v:
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 23(3)
CA 125 is a well-established marker for patients diagnosed with ovarian carcinoma. It is clearly elaborated in serous cystadenocarcinomas and less likely to be expressed in mucinous tumors. It has been 20 years since CA 125 was first recognized and i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c821443cd48ff331946ba57e6f285244
https://pubmed.ncbi.nlm.nih.gov/12218296
https://pubmed.ncbi.nlm.nih.gov/12218296
Autor:
Yinxiang Wang, Kazushi Shigemasa, Timothy J. O'Brien, Elizabeth Nestrud Schneider, Hirotoshi Tanimoto, John B. Beard, Tim H. Parmley, Lowell J. Underwood
Publikováno v:
Biochimica et biophysica acta. 1502(3)
Serine proteases serve many functions in normal biological processes. These functions are often usurped by cancer cells to allow progression of tumors by increasing the growth and metastatic potential of the neoplasia. Here, we have used a polymerase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca853807c37247ba544d88a55abb5789
https://pubmed.ncbi.nlm.nih.gov/11068177
https://pubmed.ncbi.nlm.nih.gov/11068177
Autor:
J. Fujita, Y. Tsuchihashi, Timothy J. O'Brien, A. Durando, F. Castiglione, G. Moro, Y. Yamaji, E. Manzin, Phil D. Rye, F. Nuzzo, M. Tampellini, Y. Naito, M.G. Sarobba, T. Takagi, T. Ando, R. Bitossi, P. Arese, Lowell J. Underwood, G. Bonazzi, N. Agnantis, T. Yoshikawa, K. Itani, M. Massobrio, T. Ishikawa, S. Hojo, T. Takemura, A. Berruti, A. Farris, G. Gorzegno, M. Talieri, N. Nanki, M. Donadio, A. Tzimogiani, Lyndal York, T. Ishida, Alessandro D. Santin, S. Papadopoulou, Kjell Nustad, S. Bandoh, N. Arnogianaki, N. Yoshida, L. Dogliotti, Richard A. Dennis, N. Matsumoto, E. de Fabiani, H. Hisatomi, O. Handa, A. Scorilas, Eivind Hovig, Y. Yang, A. de Matteis, B. Papapanayiotou, H. Kato, John B. Beard, A. Bottini, David J. Warren
Publikováno v:
Tumor Biology. 22:401-402
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e8a4e99f989140a4fadda02b406f2fc
https://doi.org/10.1159/000050645
https://doi.org/10.1159/000050645