Strongyloides stercoralis and HTLV-1 coinfection in CD34+ cord blood stem cell humanized mice: Alteration of cytokine responses and enhancement of larval growth.

Autor: Lauren E Springer, John B Patton, Tingting Zhan, Arnold B Rabson, Hsin-Ching Lin, Tim Manser, James B Lok, Jessica A Hess, David Abraham

Publikováno v: PLoS Neglected Tropical Diseases, Vol 15, Iss 7, p e0009559 (2021)

Viral and parasitic coinfections are known to lead to both enhanced disease progression and altered disease states. HTLV-1 and Strongyloides stercoralis are co-endemic throughout much of their worldwide ranges resulting in a significant incidence of

Externí odkaz: https://doaj.org/article/b5fb2f03c28b4784a7c66e02afdad02a

Development of Onchocerca volvulus in humanized NSG mice and detection of parasite biomarkers in urine and serum.

Autor: John B Patton, Sasisekhar Bennuru, Mark L Eberhard, Jessica A Hess, April Torigian, Sara Lustigman, Thomas B Nutman, David Abraham

Publikováno v: PLoS Neglected Tropical Diseases, Vol 12, Iss 12, p e0006977 (2018)

BackgroundThe study of Onchocerca volvulus has been limited by its host range, with only humans and non-human primates shown to be susceptible to the full life cycle infection. Small animal models that support the development of adult parasites have

Externí odkaz: https://doaj.org/article/d5eefc01f5184522a2b2fc4f3dadff49

Comparison of Lethal and Nonlethal Mouse Models of Orientia tsutsugamushi Infection Reveals T-Cell Population-Associated Cytokine Signatures Correlated with Lethality and Protection

Autor: Allen L. Richards, John B. Patton, Alison Luce-Fedrow, Suchismita Chattopadhyay, Gregory Pearson, Teik-Chye Chan

Publikováno v: Tropical Medicine and Infectious Disease
Tropical Medicine and Infectious Disease, Vol 6, Iss 121, p 121 (2021)
Tropical Medicine and Infectious Disease; Volume 6; Issue 3; Pages: 121

The antigenic diversity of Orientia tsutsugamushi as well as the interstrain difference(s) associated with virulence in mice impose the necessity to dissect the host immune response. In this study we compared the host response in lethal and non-letha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7d61808216f71c821d76afc9148b229
http://europepmc.org/articles/PMC8293330

Antibody responses against the vaccine antigens Ov-103 and Ov-RAL-2 are associated with protective immunity to Onchocerca volvulus infection in both mice and humans

Autor: Peter J. Hotez, Nancy Tricoche, Sara Lustigman, Maria Elena Bottazzi, Bin Zhan, David Abraham, Sonia Jain, Parakkal Jovvian George, Tingting Zhan, John B. Patton, Jessica A. Hess

Publikováno v: PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 13, Iss 9, p e0007730 (2019)

Background The current strategy for the elimination of onchocerciasis is based on annual or bi-annual mass drug administration with ivermectin. However, due to several limiting factors there is a growing concern that elimination of onchocerciasis can

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77833e10d291922430ff04e24c3247ee
https://pubmed.ncbi.nlm.nih.gov/31525197

The Immunomodulatory Role of Adjuvants in Vaccines Formulated with the Recombinant Antigens Ov-103 and Ov-RAL-2 against Onchocerca volvulus in Mice

Autor: April Torigian, Maria Elena Bottazzi, Nikolai Petrovsky, Jessica A. Hess, Sara Lustigman, Thomas R. Klei, Bin Zhan, Peter J. Hotez, John B. Patton, David Abraham, Tingting Zhan

Publikováno v: PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 10, Iss 7, p e0004797 (2016)

Background In some regions in Africa, elimination of onchocerciasis may be possible with mass drug administration, although there is concern based on several factors that onchocerciasis cannot be eliminated solely through this approach. A vaccine aga

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39946e3922d03550022cb6b94031ca7d
https://pubmed.ncbi.nlm.nih.gov/27387453