Zobrazeno 1 - 10
of 25
pro vyhledávání: '"John B Jordan"'
Autor:
Bryan D Moyer, Justin K Murray, Joseph Ligutti, Kristin Andrews, Philippe Favreau, John B Jordan, Josie H Lee, Dong Liu, Jason Long, Kelvin Sham, Licheng Shi, Reto Stöcklin, Bin Wu, Ruoyuan Yin, Violeta Yu, Anruo Zou, Kaustav Biswas, Les P Miranda
Publikováno v:
PLoS ONE, Vol 13, Iss 5, p e0196791 (2018)
Identification of voltage-gated sodium channel NaV1.7 inhibitors for chronic pain therapeutic development is an area of vigorous pursuit. In an effort to identify more potent leads compared to our previously reported GpTx-1 peptide series, electrophy
Externí odkaz:
https://doaj.org/article/05d6c798f5064771a7180e9f1fa3d097
Autor:
John B. Jordan, Leah Christl
Publikováno v:
Expert opinion on drug safety. 19(3)
The US Food and Drug Administration’s (FDA’s) Biosimilar Action Plan (BAP), released in 2018, provides information regarding key actions taken or to be taken by FDA to encourage innovation and comp...
Publikováno v:
Expert opinion on drug safety. 18(3)
Introduction Pharmacovigilance is essential to monitoring the safety profiles of authorized medicines. Compared with small-molecule drugs, biological drugs are more complex, more susceptible to structural variability due to manufacturing processes, a
Autor:
Peter Schmieder, Ryan M. Evans, Robert G. Brinson, Chad W. Lawrence, Kristian Schweimer, Yves Aubin, Ping Xu, Göran Widmalm, Andreas Blomgren, Hamish G. Grant, Anthony J. Kearsley, John P. Marino, Janez Plavec, John B. Jordan, Geneviève Gingras, Scott A. Bradley, Koichi Kato, Stuart Parnham, Patrick N. Reardon, John R. Cort, David W. Keizer, Edward R. Zartler, Feng Ni, Frank Delaglio, Gregor Ilc, Saeko Yanaka, David A. Keire, Jonas Ståhle, Mats Wikström, Luke W. Arbogast, Alfred Ross, Thea Suter-Stahel, Darón I. Freedberg, Ana Carolina de Mattos Zeri, Maurício L. Sforça, Nils Trieloff, Desiree Tsao, Torgny Rundlöf, Xinying Jia, Kang Chen, Ken Skidmore, Gregory K. Pierens, Houman Ghasriani, Donna M. Baldisseri, Carlos A. Amezcua, Mehdi Mobli, Julie Yu Wei, Christina M. Szabo, Gerhard Wider
Publikováno v:
mAbs
The increased interest in using monoclonal antibodies (mAbs) as a platform for biopharmaceuticals has led to the need for new analytical techniques that can precisely assess physicochemical properties of these large and very complex drugs for the pur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f183bde956423f5930af0c3d9a27c283
https://nrc-publications.canada.ca/eng/view/object/?id=633c08c1-47ae-47b0-a883-a615bb5663ce
https://nrc-publications.canada.ca/eng/view/object/?id=633c08c1-47ae-47b0-a883-a615bb5663ce
Autor:
Mirna Mujacic, John B. Jordan, Pranhitha Reddy, Aleksander Swietlow, Vivian S. W. Li, Tisha San Miguel, Paul Kodama, Anne-Marie C Rousseau, Seb Caille, E. Allen Sickmier, Michael J. Frohn, Dhanashri Bagal, Steve Osgood, Christopher H. Fotsch, Ki Won Kim, John D. McCarter, Mike Achmatowicz, Oliver R. Thiel, Alex Pickrell, Yong-Jae Kim, John G. Allen
Publikováno v:
ACS Chemical Biology. 11:2734-2743
The efficacy of therapeutic antibodies that induce antibody-dependent cellular cytotoxicity can be improved by reduced fucosylation. Consequently, fucosylation is a critical product attribute of monoclonal antibodies produced as protein therapeutics.
Autor:
Wesley W. Barnhart, John B. Jordan, Kyung H. Gahm, Mei-Chu Lo, Heather Eastwood, John D. McCarter, Fang Xia, Jing Zhou
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 115:402-409
Analysis of nucleotide sugars, nucleoside di- and triphosphates and sugar-phosphates is an essential step in the process of understanding enzymatic pathways. A facile and rapid separation method was developed to analyze these compounds present in an
Autor:
John B. Jordan, Justin K. Murray, Kristin L. Andrews, Licheng Shi, Philippe Favreau, Ruoyuan Yin, Violeta Yu, Josie H. Lee, Kelvin K. C. Sham, Bin Wu, Kaustav Biswas, Dong Liu, Anruo Zou, Joseph Ligutti, Jason Long, Les P. Miranda, Bryan D. Moyer, Reto Stöcklin
Publikováno v:
PLoS ONE, Vol 13, Iss 5, p e0196791 (2018)
PLoS ONE
PLoS ONE
Identification of voltage-gated sodium channel NaV1.7 inhibitors for chronic pain therapeutic development is an area of vigorous pursuit. In an effort to identify more potent leads compared to our previously reported GpTx-1 peptide series, electrophy
Autor:
John B, Jordan, Douglas A, Whittington, Michael D, Bartberger, E Allen, Sickmier, Kui, Chen, Ryan D, White, Yuan, Cheng, Ted, Judd
Publikováno v:
Journal of medicinal chemistry. 60(7)
Autor:
Elaine Tuomanen, Mark R. Alderson, Kristin R. Wade, Geli Gao, John B. Jordan, Jeff Maisonneuve, Beth Mann, Karim C. El Kasmi, Diana M. Mitrea, Justin A. Thornton, Richard W. Kriwacki, Rodney K. Tweten, Richard J. Heath
Publikováno v:
The Journal of Infectious Diseases. 209:1116-1125
Background. Pneumococcus, meningococcus, and Haemophilus influenzae cause a similar spectrum of infections in the ear, lung, blood, and brain. They share cross-reactive antigens that bind to the laminin receptor of the blood-brain barrier as a molecu
Autor:
Leszek Poppe, Paul D. Schnier, John B. Jordan, Jeffrey Lewis, Klaus Michelsen, Peter Yakowec, Evelyn Yang, Xin Huang, Jing Zhou, Alexander M. Long, Yosup Rew
Publikováno v:
Journal of the American Chemical Society. 134:17059-17067
Restoration of p53 function through the disruption of the MDM2-p53 protein complex is a promising strategy for the treatment of various types of cancer. Here, we present kinetic, thermodynamic, and structural rationale for the remarkable potency of a