Zobrazeno 1 - 10 of 457 pro vyhledávání: '"John B, Porter"'
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Akademický článek
Effects of green tea extract treatment on erythropoiesis and iron parameters in iron-overloaded β-thalassemic mice
Autor: Kornvipa Settakorn, Sarawut Kongkarnka, Anchan Chompupoung, Saovaros Svasti, Suthat Fucharoen, John B. Porter, Somdet Srichairatanakool, Pimpisid Koonyosying
Publikováno v: Frontiers in Physiology, Vol 13 (2022)
β-Thalassemia is characterized by ineffective erythropoiesis leading to chronic anemia. Thus, increased iron absorption from the duodenum and via blood transfusions is required to maintain normal blood hemoglobin (Hb) levels and iron chelators in th
Externí odkaz: https://doaj.org/article/e5ba8c85dd244e7494910c7eb24a8e09
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6
The clinical relevance of detectable plasma iron species in iron overload states and subsequent to intravenous iron‐carbohydrate administration
Autor: Maciej W. Garbowski, Ioav Cabantchik, Chaim Hershko, Robert Hider, John B. Porter
Publikováno v: American Journal of Hematology. 98:533-540
Many disorders of iron homeostasis (e.g., iron overload) are associated with the dynamic kinetic profiles of multiple non-transferrin bound iron (NTBI) species, chronic exposure to which is associated with deleterious end-organ effects. Here we discu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0a150482e03451da7cb4eb5f6750fba
https://doi.org/10.1002/ajh.26819
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7
Akademický článek
Intravenous iron preparations transiently generate non-transferrin-bound iron from two proposed pathways
Autor: Maciej W. Garbowski, Sukhvinder Bansal, John B. Porter, Claudio Mori, Susanna Burckhardt, Robert C. Hider
Publikováno v: Haematologica, Vol 106, Iss 11 (2020)
Intravenous iron-carbohydrate complex preparations (IVIP) are noninterchangeable pro-drugs: their pharmacokinetics (PK) varies determined by semi-crystalline iron core and carbohydrate shell structures, influences pharmacodynamics (PD) and thus effic
Externí odkaz: https://doaj.org/article/b440efa78273454f8ec0270525d82463
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9
Akademický článek
Patient-reported outcomes from a randomized phase II study of the deferasirox film-coated tablet in patients with transfusion-dependent anemias
Autor: Ali T. Taher, Raffaella Origa, Silverio Perrotta, Alexandra Kouraklis, Giovan Battista Ruffo, Antonis Kattamis, Ai-Sim Goh, Vicky Huang, Aiesha Zia, Raquel Merino Herranz, John B. Porter
Publikováno v: Health and Quality of Life Outcomes, Vol 16, Iss 1, Pp 1-12 (2018)
Abstract Background Adherence to long-term chelation therapy in transfusion-dependent patients is critical to prevent iron overload-related complications. Once-daily deferasirox dispersible tablets (DT) have proven long-term efficacy and safety in pa
Externí odkaz: https://doaj.org/article/25b01dba630d4a928d6fd8ff60c35b9f
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10
Akademický článek
Post-mortem study of the association between cardiac iron and fibrosis in transfusion dependent anaemia
Autor: Paul Kirk, Mary Sheppard, John-Paul Carpenter, Lisa Anderson, Taigang He, Tim St Pierre, Renzo Galanello, Gualtiero Catani, John Wood, Suthat Fucharoen, John B Porter, J Malcolm Walker, Gian Luca Forni, Dudley J Pennell
Publikováno v: Journal of Cardiovascular Magnetic Resonance, Vol 19, Iss 1, Pp 1-9 (2017)
Abstract Background Heart failure related to cardiac siderosis remains a major cause of death in transfusion dependent anaemias. Replacement fibrosis has been reported as causative of heart failure in siderotic cardiomyopathy in historical reports, b
Externí odkaz: https://doaj.org/article/86f0812fe37546c18207c79c6d2b492b
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