Zobrazeno 1 - 10
of 867
pro vyhledávání: '"John B, Holcomb"'
Autor:
Jeremy W. Cannon, Danielle S. Gruen, Ruben Zamora, Noah Brostoff, Kelly Hurst, John H. Harn, Fayten El-Dehaibi, Zhi Geng, Rami Namas, Jason L. Sperry, John B. Holcomb, Bryan A. Cotton, Jason J. Nam, Samantha Underwood, Martin A. Schreiber, Kevin K. Chung, Andriy I. Batchinsky, Leopoldo C. Cancio, Andrew J. Benjamin, Erin E. Fox, Steven C. Chang, Andrew P. Cap, Yoram Vodovotz
Publikováno v:
Communications Medicine, Vol 4, Iss 1, Pp 1-12 (2024)
Abstract Background Optimizing resuscitation to reduce inflammation and organ dysfunction following human trauma-associated hemorrhagic shock is a major clinical hurdle. This is limited by the short duration of pre-clinical studies and the sparsity o
Externí odkaz:
https://doaj.org/article/4ec280b49b694ff292ab1c9cd28a37b5
Autor:
Kyosuke Takahashi, Kazuma Yamakawa, Anaar E. Siletz, Morihiro Katsura, John B. Holcomb, Charles E. Wade, Jessica C. Cardenas, Erin E. Fox, Morgan Schellenberg, Matthew Martin, Kenji Inaba, Kazuhide Matsushima
Publikováno v:
Research and Practice in Thrombosis and Haemostasis, Vol 8, Iss 7, Pp 102568- (2024)
Background: Traumatic fibrinolytic dysfunction is often categorized into 3 phenotypes based on the result of thromboelastography (TEG) lysis at 30 minutes (LY30): fibrinolysis shutdown, physiologic fibrinolysis, and hyperfibrinolysis. However, the mo
Externí odkaz:
https://doaj.org/article/f4cf5330566f4d55b2eff6c34898cffe
Autor:
John B Holcomb, Jeffrey David Kerby, Parker Hu, Jan O Jansen, Daniel Lammers, Omar Rokayak, Emily W Baird, Richard D Betzold, Zain Hashmi
Publikováno v:
Trauma Surgery & Acute Care Open, Vol 9, Iss 1 (2024)
Introduction Whole blood (WB) transfusion represents a promising resuscitation strategy for trauma patients. However, a paucity of data surrounding the optimal incorporation of WB into resuscitation strategies persists. We hypothesized that traumatic
Externí odkaz:
https://doaj.org/article/756028b6b3164342b37fb64af7d79f4d
Autor:
Mark H. Yazer, Gleb Panko, John B. Holcomb, Alesia Kaplan, Christine Leeper, Jansen N. Seheult, Darrell J. Triulzi, Philip C. Spinella
Publikováno v:
Hematology, Vol 28, Iss 1 (2023)
ABSTRACTThe use of blood products to resuscitate injured and massively bleeding patients in the prehospital and early in-hospital phase of the resuscitation is increasing. Using group O red blood cells (RBC) and low titer group O whole blood (LTOWB)
Externí odkaz:
https://doaj.org/article/4630cf0098ef47279167f40e163306e7
Autor:
Andrew J. Benjamin, MD, Andrew J. Young, MD, John B. Holcomb, MD, Erin E. Fox, PhD, Charles E. Wade, PhD, Chris Meador, MBA, Jeremy W. Cannon, MD, SM
Publikováno v:
Annals of Surgery Open, Vol 4, Iss 3, p e314 (2023)
Objective:. Develop a novel machine learning (ML) model to rapidly identify trauma patients with severe hemorrhage at risk of early mortality. Background:. The critical administration threshold (CAT, 3 or more units of red blood cells in a 60-minute
Externí odkaz:
https://doaj.org/article/f0c2ff8f1f1143508eca454cf911e23d
Autor:
John B Holcomb, Charles C Miller, Charles E Wade, Jan Jansen, Jessica Cardenas, Daniel Lammers, Michelle Scerbo, Annamaria Davidson, Matthew Pommerening, Jeffrey Tomasek
Publikováno v:
Trauma Surgery & Acute Care Open, Vol 8, Iss 1 (2023)
Background Trauma patients exhibit a multifactorial hypercoagulable state and have increased risk of venous thromboembolism (VTE). Despite early and aggressive chemoprophylaxis (CP) with various heparin compounds (“standard” CP; sCP), VTE rates r
Externí odkaz:
https://doaj.org/article/7bc96c48d9ba4efe80d4f13870b9ba47
Autor:
John B Holcomb, Rindi Uhlich, Joshua Richman, Daniel Lammers, Omar Rokayak, Thomas Sensing, Emily Baird
Publikováno v:
Trauma Surgery & Acute Care Open, Vol 8, Iss 1 (2023)
Introduction The Pragmatic Randomized Optimal Platelet and Plasma Ratios (PROPPR) trial failed to demonstrate a mortality difference for hemorrhaging patients receiving a balanced (1:1:1) vs a 1:1:2 resuscitation at 24 hours and 30 days. Recent guide
Externí odkaz:
https://doaj.org/article/1c5ae7f7be8546519731aa72eb1d67bf
Autor:
John B Holcomb, Tiziana Cena, David Lockey, Luca Montagnani, Simona Cavallo, Andrea Cortegiani, Lorenzo Gamberini, Carlo Coniglio, Marco Tartaglione, Valentina Chiarini, Cristian Lupi, Giovanni Gordini, Tobias Gauss, Aimone Giugni, Maria Teresa Strano, Luca Carenzo, Carlo Alberto Mazzoli, Silvia Cavagna, Davide Allegri, Giovanni Sbrana, Andrea Caglià, Jacopo Pernechele, Andrea Mina, Roberto Vacca, Roberto Gioachin, Valeria Bonato, Claudia Monge, Paolo Frisoni, Luca Nicora, Giovanna Zilio, Cristina Barbarino, Andrea Paoli, Giacomo Magagnotti, Andrea Spagna, Alberto Trincanato, Francesca Verginella, Marta Pescolderung, Stefania Armani, Adriano Valerio, Giulio Desiderio, Edoardo Picetti, Michela Ciminello, Christian Tosato, Yuri Ferrara, Stefano Barbadori, Silvia Pini, Andrea Vignali, Alberto Baratta, Davide Durì, Calogero Centonze, Matteo Ciccolini, Alessandra Spasiano, Tommaso Marzano, Guido Gambetti, Domenico Minniti, Michela Rauseo, Gilda Cinnella, Rosanna Vaschetto, Giacomo Iapichino, Fabio Genco, Antonio Iacono, Annalisa Deiana, Marco Vidili, Massimiliano Carta, Alessio Ficarella, Flavia Baccari
Publikováno v:
BMJ Open, Vol 12, Iss 5 (2022)
Introduction Major haemorrhage after injury is the leading cause of preventable death for trauma patients. Recent advancements in trauma care suggest damage control resuscitation (DCR) should start in the prehospital phase following major trauma. In
Externí odkaz:
https://doaj.org/article/1e4a82b64d404fde866a2e501b3b5c53
Autor:
Raul Coimbra, Megan Brenner, John B Holcomb, Jeanette Podbielski, Kenji Inaba, Thomas Scalea, Mark Seamon, Jonathan Morrison, Chance Spalding, Charles Fox, Ernest E Moore, Jeremy W Cannon, Laura J Moore, Bishoy Zakhary, Joseph Abdellatif Ibrahim
Publikováno v:
Trauma Surgery & Acute Care Open, Vol 7, Iss 1 (2022)
Background The effects of aortic occlusion (AO) on brain injury are not well defined. We examined the impact of AO by resuscitative endovascular balloon occlusion of the aorta (REBOA) and resuscitative thoracotomy (RT) on outcomes in the setting of t
Externí odkaz:
https://doaj.org/article/a76ce72f4c2542dc8c9c8a5ac41be24d
Autor:
Robert P. Richter, MD, Danielle M. Joiner, BS, Russell L. Griffin, PhD, Jan O. Jansen, MBBS, PhD, Jeffrey D. Kerby, MD, PhD, Charles E. Wade, PhD, John B. Holcomb, MD, Jessica C. Cardenas, PhD, Jillian R. Richter, PhD
Publikováno v:
Annals of Surgery Open, Vol 3, Iss 1, p e116 (2022)
Objectives:. Determine associations between biomarkers of endotheliopathy, 24-hour fibrinolysis phenotypes and clinical outcomes after trauma. Background:. The vascular endothelium is a critical regulator of hemostasis and organ function. The relatio
Externí odkaz:
https://doaj.org/article/fc7da8c476d14c23a29a9cf5ccca69b0