Zobrazeno 1 - 5
of 5
pro vyhledávání: '"John Arcaroli"'
Autor:
Aaron J Scott, Eun-Kee Song, Stacey Bagby, Alicia Purkey, Martin McCarter, Csaba Gajdos, Kevin S Quackenbush, Benjamin Cross, Todd M Pitts, Aik Choon Tan, S Gail Eckhardt, Hubert Fenton, John Arcaroli, Wells A Messersmith
Publikováno v:
PLoS ONE, Vol 12, Iss 11, p e0187173 (2017)
Dysregulation of the Src pathway has been shown to be important at various stages of cancer. Dasatinib is a potent Src/Abl inhibitor and has demonstrated to have anti-proliferative and anti-invasive activity in many preclinical models. The objective
Externí odkaz:
https://doaj.org/article/ffa9c06bfd5b415295825fb53b2a273e
Autor:
Sreedevi Avasarala, Michelle Van Scoyk, Jianbin Wang, Marybeth Sechler, Katherine Vandervest, Christine Brzezinski, Colin Weekes, Michael G. Edwards, John Arcaroli, Richard E. Davis, Rama Kamesh Bikkavilli, Robert A. Winn
Publikováno v:
Biology Open, Vol 2, Iss 7, Pp 675-685 (2013)
Summary In non-small cell lung cancer cell lines, activation of β-catenin independent signaling, via Wnt7a/Frizzled9 signaling, leads to reversal of cellular transformation, reduced anchorage-independent growth and induction of epithelial differenti
Externí odkaz:
https://doaj.org/article/d80a964b26394244a9acc16c3035e418
Autor:
Colin D. Weekes, Dongweon Song, John Arcaroli, Lora A. Wilson, Belen Rubio-Viqueira, George Cusatis, Elizabeth Garrett-Mayer, Wells A. Messersmith, Robert A. Winn, Manuel Hidalgo
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 14, Iss 8, Pp 690-701 (2012)
PURPOSE: The factors preventing the translation of preclinical findings supporting the clinical development mTOR-targeted therapy in pancreatic cancer therapy remain undetermined. Stromal cell.derived factor 1α (SDF-1α)-CXCR4 signaling was examined
Externí odkaz:
https://doaj.org/article/aba201eee29846aebff0ad9a9f9563f3
Autor:
Surendra Singh, John Arcaroli, Ying Chen, David C Thompson, Wells Messersmith, Antonio Jimeno, Vasilis Vasiliou
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0121648 (2015)
In the normal human colon, aldehyde dehydrogenase 1B1 (ALDH1B1) is expressed only at the crypt base, along with stem cells. It is also highly expressed in the human colonic adenocarcinomas. This pattern of expression corresponds closely to that obser
Externí odkaz:
https://doaj.org/article/2430f5a9d55b4f758df9bc478b121f96
Autor:
James Murphy, James P. Maloney, Edward Abraham, Daiva Svetkauskaite, John Arcaroli, Eliezer Silva, Qianbin He
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 173:1335-1341
Rationale: The IL-1 receptor–associated kinase (IRAK-1) plays a central role in TLR2- and TLR4-induced activation of nuclear factor (NF)-κB, a critical event in the transcriptional regulation of many sepsis-associated proinflammatory mediators. Th