Zobrazeno 1 - 10
of 16
pro vyhledávání: '"John Andrew MacKay"'
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
Rapamycin (Rapa) is a highly potent drug; however, its clinical potential is limited by poor solubility, bioavailability, and cytotoxicity. To improve Rapa delivery, our team has fused the cognate protein receptor for Rapa, FKBP12, to high molecular
Externí odkaz:
https://doaj.org/article/15dd2c995bd8435d83492f603677a9ac
Autor:
John Andrew MacKay, Santosh Peddi
Publikováno v:
Biomacromolecules
Rapalogues are a unique class of drugs with both cytostatic and immunosuppressive properties. Two founding members, rapamycin (Rapa) and its chemical derivative everolimus (Eve), are extremely potent, but their clinical use presents multiple challeng
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d074598c853775a6790aef60dcfc6fc
https://doi.org/10.1021/acs.biomac.0c00375
https://doi.org/10.1021/acs.biomac.0c00375
Publikováno v:
Biomacromolecules
The clinical utility of Rapamycin (Rapa) is limited by solubility, bioavailability, and side effects. To overcome this, our team recently reported an elastin-like polypeptide (ELP) nanoparticle with high-affinity, non-covalent drug-binding as well as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9778f412500aba38d1e4906fd85cc31
https://doi.org/10.1021/acs.biomac.9b01431
https://doi.org/10.1021/acs.biomac.9b01431
Publikováno v:
ACS Biomater Sci Eng
Elastin-like polypeptides (ELPs) are modular, stimuli-responsive materials that self-assemble into protein-rich microdomains in response to heating. By cloning ELPs to effector proteins, expressed intracellular fusions can even modulate cellular path
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24faff7acfe34e5a5ad8fd6b9b3f1353
https://pubmed.ncbi.nlm.nih.gov/33455201
https://pubmed.ncbi.nlm.nih.gov/33455201
Autor:
Hugo Avila, Sarah F. Hamm-Alvarez, John Andrew MacKay, Mincheol Park, David R. Tyrpak, Hao Guo, Anh Truong, Runzhong Fu, Yue Wang, Curtis T. Okamoto
Publikováno v:
ACS Biomater Sci Eng
Caveolae are membrane organelles formed by submicron invaginations in the plasma membrane, and are involved in mechanosensing, cell signaling, and endocytosis. Although implicated broadly in physiology and pathophysiology, better tools are required t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d1682c574171e100c35bc6eef879699
https://pubmed.ncbi.nlm.nih.gov/32542186
https://pubmed.ncbi.nlm.nih.gov/32542186
Publikováno v:
Bioconjug Chem
Human granulocyte-macrophage colony-stimulating factor (hGMCSF) is crucial in the immune system as it stimulates survival, proliferation, differentiation, and functional activation of myeloid hematopoietic cells. hGMCSF is integral to approved therap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1608f49312abbb705fec3bd144813243
https://pubmed.ncbi.nlm.nih.gov/32319752
https://pubmed.ncbi.nlm.nih.gov/32319752
Autor:
Yong Zhang, Houda Alachkar, Mincheol Park, John Andrew MacKay, Vijaya Pooja Vaikari, Albert T. Lam
Publikováno v:
J Control Release
FLT3 receptor is an important therapeutic target in acute myeloid leukemia due to high incidence of mutations associated with poor clinical outcome. Targeted therapies against the FLT3 receptor, including small-molecule FLT3 tyrosine kinase inhibitor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::944b078af663e42fbecbee54831e2fb2
https://pubmed.ncbi.nlm.nih.gov/32428520
https://pubmed.ncbi.nlm.nih.gov/32428520
Autor:
Nicholas J. Abuid, Aitor Álvarez, Candace Benjamin, Agata Blasiak, Olivia Brohlin, Sean Burkitt, Jos Campbell, Carolina Carrillo-Carrión, Yahya Cheema, Andreina Chiu-Lam, Eun Ji Chung, Nathan D. Donahue, Natalie Dong, Mitsushita Doomra, Marco A. Downing, Omolola Eniola-Adefeso, Allen Eyler, Catherine A. Fromen, Eric Fuller, Tiffany RX. Gan, Jeremiah J. Gassensmith, Kerim M. Gattás-Asfura, Mengjie Gu, Hao Guo, Ankur Gupta, Dean Ho, Leaf Huang, Huang-Chiao Huang, Collin T. Inglut, Aaron J. Sorrin, Piyush K. Jain, Bader M. Jarai, Edward Kai-Hua Chow, Theodore Kee, Jeffrey Khong, Forrest M. Kievit, Jonathan Kin-Hun Lee, Emily L. Kolewe, Truong Thanh Lan Anh, Daniel J. LaShoto, Tram Le, Dao P. Le, Joanne C. Lee, Lorraine Leon, Barry J. Liang, John Andrew MacKay, Raquel Martínez, Tyler Maxwell, Michael McKenna, Samantha A. Meenach, Michael Mellas, Martina Migliavacca, Daniel Najafali, Elizabeth Nance, Steven M. Narum, María F. Navarro Poupard, Jiansheng Ng, Maria Gabriela Nogueira Campos, Beatriz Pelaz, Pablo del Pino, Ester Polo, Alexia M. Poulos, Nisha Raman, Carlos Rinaldi, Angelie Rivera-Rodriguez, Hanieh Safari, Swadeshmukul Santra, Shehaab Savliwala, Kacoli Sen, Nishan K. Shah, Sachit Shah, Arezoo Shahrivarkevishahi, Stephen Smith, Enrica Soprano, Jillian Stabile, Cherie L. Stabler, Zachary S. Stillman, Sara Tabandeh, Aria W. Tarudji, Marcus Threadcraft, Zon Thwin, Matthew Tirrell, Elisa A. Torrico Guzmán, Mythreyi Unni, Swapna Vaja, Jonathan Wang, Peter Wang, Zimeng Wang, Stefan Wilhelm, Jingru Xu, Wen Yang, Cristina Zavaleta, Yuan Zhang
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a1ea9c974bd29f0237e745c8d5a06de
https://doi.org/10.1016/b978-0-12-816662-8.01002-x
https://doi.org/10.1016/b978-0-12-816662-8.01002-x
Autor:
Hao Guo, John Andrew MacKay
As for any drug, nanomedicines must achieve a pharmacokinetic (PK) profile that is acceptable in the clinic. To do so, PK parameters should be evaluated through rigorous structure–function studies during preclinical development. The purpose of this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a8a2992676a011d7d056b378354d7ad
https://doi.org/10.1016/b978-0-12-816662-8.00008-4
https://doi.org/10.1016/b978-0-12-816662-8.00008-4
Publikováno v:
Advanced biosystems. 2(10)
Subcellular events such as trafficking and signaling are regulated by self-assembled protein complexes inside the cell. The ability to rapidly and reversibly manipulate these protein complexes would likely enhance studies of their mechanisms and thei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c57155fc17e3cfc0476491ad4e5743b
https://pubmed.ncbi.nlm.nih.gov/31840042
https://pubmed.ncbi.nlm.nih.gov/31840042