Zobrazeno 1 - 10
of 16
pro vyhledávání: '"John Alan Maschek"'
Autor:
Sicheng Zhang, Kevin J. Williams, Amandine Verlande-Ferrero, Alvin P. Chan, Gino B. Su, Erin E. Kershaw, James E. Cox, John Alan Maschek, Suzanne N. Shapira, Heather R. Christofk, Thomas Q. de Aguiar Vallim, Selma Masri, Claudio J. Villanueva
Publikováno v:
Journal of Lipid Research, Vol 65, Iss 2, Pp 100434- (2024)
Adipose tissue is the site of long-term energy storage. During the fasting state, exercise, and cold exposure, the white adipose tissue mobilizes energy for peripheral tissues through lipolysis. The mobilization of lipids from white adipose tissue to
Externí odkaz:
https://doaj.org/article/ff3c3ea9925a42a1b4513e62d017e176
Autor:
Hiroaki Eshima, Justin L Shahtout, Piyarat Siripoksup, MacKenzie J Pearson, Ziad S Mahmassani, Patrick J Ferrara, Alexis W Lyons, John Alan Maschek, Alek D Peterlin, Anthony RP Verkerke, Jordan M Johnson, Anahy Salcedo, Jonathan J Petrocelli, Edwin R Miranda, Ethan J Anderson, Sihem Boudina, Qitao Ran, James E Cox, Micah J Drummond, Katsuhiko Funai
Publikováno v:
eLife, Vol 12 (2023)
Reactive oxygen species (ROS) accumulation is a cardinal feature of skeletal muscle atrophy. ROS refers to a collection of radical molecules whose cellular signals are vast, and it is unclear which downstream consequences of ROS are responsible for t
Externí odkaz:
https://doaj.org/article/c52cb2601b414254b20d382cbc82c75b
Autor:
Megan Okada, Krithika Rajaram, Russell P Swift, Amanda Mixon, John Alan Maschek, Sean T Prigge, Paul A Sigala
Publikováno v:
eLife, Vol 11 (2022)
Isopentenyl pyrophosphate (IPP) is an essential metabolic output of the apicoplast organelle in Plasmodium falciparum malaria parasites and is required for prenylation-dependent vesicular trafficking and other cellular processes. We have elucidated a
Externí odkaz:
https://doaj.org/article/d6c5aa846c6547d3ac466ffd5e45ea8e
Autor:
Bhagirath Chaurasia, Li Ying, Chad Lamar Talbot, John Alan Maschek, James Cox, Edward H. Schuchman, Yoshio Hirabayashi, William L. Holland, Scott A. Summers
Publikováno v:
Molecular Metabolism, Vol 45, Iss , Pp 101145- (2021)
Objective: Aging and weight gain lead to a decline in brown and beige adipocyte functionality that exacerbates obesity and insulin resistance. We sought to determine whether sphingolipids, such as ceramides, a class of lipid metabolites that accumula
Externí odkaz:
https://doaj.org/article/9975020d704c4ea98cfc8e762cab31b4
Autor:
Patrick J Ferrara, Marisa J Lang, Jordan M Johnson, Shinya Watanabe, Kelsey L McLaughlin, John Alan Maschek, Anthony R P Verkerke, Piyarat Siripoksup, Amandine Chaix, James E Cox, Kelsey H Fisher-Wellman, Katsuhiko Funai
Publikováno v:
Life Metab
Weight loss from an overweight state is associated with a disproportionate decrease in whole-body energy expenditure that may contribute to the heightened risk for weight regain. Evidence suggests that this energetic mismatch originates from lean tis
Autor:
Justin L Shahtout, Hiroaki Eshima, Piyarat Siripoksup, MacKenzie J Pearson, Ziad S Mahmassani, Patrick J Ferrara, Alexis W Lyons, John Alan Maschek, Alek D Peterlin, Anthony RP Verkerke, Jordan M Johnson, Anahy Salcedo, Jonathan J Petrocelli, Edwin R Miranda, Ethan J Anderson, Sihem Boudina, Qitao Ran, James E Cox, Micah J Drummond, Katsuhiko Funai
Publikováno v:
eLife. 12
SummaryReactive oxygen species (ROS) accumulation is a cardinal feature of skeletal muscle atrophy. ROS refers to a collection of radical molecules whose cellular signals are vast, and it is unclear which downstream consequences of ROS are responsibl
Autor:
Justin L Shahtout, Hiroaki Eshima, Piyarat Siripoksup, MacKenzie J Pearson, Ziad S Mahmassani, Patrick J Ferrara, Alexis W Lyons, John Alan Maschek, Alek D Peterlin, Anthony RP Verkerke, Jordan M Johnson, Anahy Salcedo, Jonathan J Petrocelli, Edwin R Miranda, Ethan J Anderson, Sihem Boudina, Qitao Ran, James E Cox, Micah J Drummond, Katsuhiko Funai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68e7eb61bb5551c675fd037ca1a17842
https://doi.org/10.7554/elife.85289.sa2
https://doi.org/10.7554/elife.85289.sa2
Autor:
Russell P. Swift, Sean T. Prigge, Krithika Rajaram, John Alan Maschek, Amanda Mixon, Paul A. Sigala, Megan Okada
Publikováno v:
eLife. 11
Isopentenyl pyrophosphate (IPP) is an essential metabolic output of the apicoplast organelle in Plasmodium falciparum malaria parasites and is required for prenylation-dependent vesicular trafficking and other cellular processes. We have elucidated a
Autor:
John Alan Maschek, Xiaoyong Xu, Chun-yang Huang, Yoshiyuki Ikeda, Trevor S. Tippetts, Wataru Mizushima, Shinichi Oka, Guersom Ralda, Mingming Tong, Sundararajan Venkatesh, Sanchita Kashyap, Jaemin Byun, Peiyong Zhai, Junco S. Warren, Nobushige Imai, Junichi Sadoshima, Toshihide Kashihara
Publikováno v:
Circ Res
Rationale: Diabetic cardiomyopathy is accompanied by increased production of NADH, predominantly through oxidation of fatty acids and consequent increases in oxidative stress. The role of Nampt (nicotinamide phosphoribosyltransferase), the rate-limit