Zobrazeno 1 - 8
of 8
pro vyhledávání: '"John Alan Diehl"'
Autor:
Michael A Augello, Lisa D Berman‐Booty, Richard Carr, Akihiro Yoshida, Jeffry L Dean, Matthew J Schiewer, Felix Y Feng, Scott A Tomlins, Erhe Gao, Walter J Koch, Jeffrey L Benovic, John Alan Diehl, Karen E Knudsen
Publikováno v:
EMBO Molecular Medicine, Vol 7, Iss 5, Pp 628-647 (2015)
Abstract Clinical evidence suggests that cyclin D1b, a variant of cyclin D1, is associated with tumor progression and poor outcome. However, the underlying molecular basis was unknown. Here, novel models were created to generate a genetic switch from
Externí odkaz:
https://doaj.org/article/c0a939ceeb9240749fd9c3c0d5d3e22e
Autor:
Ireneusz Majsterek, Radosław Wojtczak, Anna Walczak, Adam Wawrzynkiewicz, Wioletta Rozpędek, Dariusz Pytel, John Alan Diehl, Bartosz Mucha, Tomasz Poplawski, Kinga Gradzik
Publikováno v:
Current Alzheimer Research. 16:209-218
Objectives: There is a body of evidence that neurodegenerative disease entities are directly correlated with the perturbations on the molecular level. Hence, the ER stress-mediated Unfolded Protein Response (UPR) is activated resulting in PERK-depend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccfbf1e7d0f9b9daa7b20ed3bf653398
https://doi.org/10.2174/1567205016666190228121157
https://doi.org/10.2174/1567205016666190228121157
Autor:
Steven L. Carroll, Wioletta Rozpędek-Kamińska, Natalia Siwecka, Dariusz Pytel, Ewa Kucharska, Ireneusz Majsterek, Grzegorz Galita, John Alan Diehl
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 4494, p 4494 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 9
International Journal of Molecular Sciences
Volume 22
Issue 9
Primary open-angle glaucoma (POAG) constitutes the most common type of glaucoma. Emerging evidence suggests that Endoplasmic Reticulum (ER) stress and the protein kinase RNA-like endoplasmic reticulum kinase (PERK)-mediated Unfolded Protein Response
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::700b409cbee0bfdbdd0177e372a87f38
https://www.mdpi.com/1422-0067/22/9/4494
https://www.mdpi.com/1422-0067/22/9/4494
Publikováno v:
Oncogene
The serine/threonine endoplasmic reticulum (ER) kinase, protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK), is a pro-adaptive protein kinase whose activity is regulated indirectly by protein misfolding within the ER. Since the oxidative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b734d5746222334cb4b8874458811d38
https://doi.org/10.1038/onc.2015.178
https://doi.org/10.1038/onc.2015.178
Autor:
Richard Carr, Walter J. Koch, Matthew J. Schiewer, Akihiro Yoshida, Lisa D. Berman-Booty, John Alan Diehl, Erhe Gao, Karen E. Knudsen, Scott A. Tomlins, Jeffry L. Dean, Felix Y. Feng, Michael A. Augello, Jeffrey L. Benovic
Publikováno v:
EMBO Molecular Medicine
Clinical evidence suggests that cyclin D1b, a variant of cyclin D1, is associated with tumor progression and poor outcome. However, the underlying molecular basis was unknown. Here, novel models were created to generate a genetic switch from cyclin D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa5adb13ea380f427cbefd7a48466f6e
https://doi.org/10.15252/emmm.201404242
https://doi.org/10.15252/emmm.201404242
Autor:
Ireneusz Majsterek, Dariusz Pytel, Mucha B, John Alan Diehl, Wioletta Rozpędek, Leszczynska H
Publikováno v:
Current molecular medicine. 16(6)
Hypoxia is a major hallmark of the tumor microenvironment that is strictly associated with rapid cancer progression and induction of metastasis. Hypoxia inhibits disulfide bond formation and impairs protein folding in the Endoplasmic Reticulum (ER).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::911c65caa85f7cc02ea69b6307a426e9
https://pubmed.ncbi.nlm.nih.gov/27211800
https://pubmed.ncbi.nlm.nih.gov/27211800
Autor:
Karlyne M. Reilly, Dagan A. Loisel, Shirley Tsang, Robert G. Tuskan, Karl W. Broman, John Alan Diehl, Zhonghe Sun, Roderick T. Bronson, Emily S. Christy, David J. Munroe
Publikováno v:
Cancer Research. 66:62-68
Cancer is a complex disease in which cells acquire many genetic and epigenetic alterations. We have examined how three types of alterations, mutations in tumor suppressor genes, changes in an imprinted locus, and polymorphic loci, interact to affect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27c87190f340dfbdf730e12af8b59499
https://doi.org/10.1158/0008-5472.can-05-1480
https://doi.org/10.1158/0008-5472.can-05-1480
Autor:
John Alan Diehl, Yiwen Bu
Publikováno v:
Cancer Research. 76:A01-A01
The Endoplasmic Reticulum, ER, senses both intracellular and extracellular stimuli that perturb the folding and maturation of secretory proteins that transit the ER. In the context of neoplastic growth, oncogenes such as c-Myc, H-Ras and BRAF trigger
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::58519ef574701ed49d93cce3e2a71a65
https://doi.org/10.1158/1538-7445.nonrna15-a01
https://doi.org/10.1158/1538-7445.nonrna15-a01