Zobrazeno 1 - 10
of 14
pro vyhledávání: '"John Abou-Hamad"'
Autor:
John Abou-Hamad, Jonathan J. Hodgins, Edward Yakubovich, Barbara C. Vanderhyden, Michele Ardolino, Luc A. Sabourin
Publikováno v:
Cells, Vol 13, Iss 1, p 73 (2023)
Targeted therapy resistance frequently develops in melanoma due to intratumor heterogeneity and epigenetic reprogramming. This also typically induces cross-resistance to immunotherapies. Whether this includes additional modes of therapy has not been
Externí odkaz:
https://doaj.org/article/379f6adab2d44074b070f701d04bf5df
Autor:
John Abou-Hamad, Jonathan J. Hodgins, Christiano T. de Souza, Brennan Garland, Cédrik Labrèche, Marie Marotel, Cameron Gibson, Samuel Delisle, Julia Pascoal, Rebecca C. Auer, Michele Ardolino, Luc A. Sabourin
Publikováno v:
iScience, Vol 25, Iss 12, Pp 105524- (2022)
Summary: SOX10 is a key regulator of melanoma progression and promotes a melanocytic/differentiated state. Here we identified melanoma cell lines lacking SOX10 expression which retain their in vivo growth capabilities. More importantly, we find that
Externí odkaz:
https://doaj.org/article/627ac5f7b4ef457cb4fd187908d34dd8
Autor:
Cédrik Labrèche, David P. Cook, John Abou-Hamad, Julia Pascoal, Benjamin R. Pryce, Khalid N. Al-Zahrani, Luc A. Sabourin
Publikováno v:
Breast Cancer Research, Vol 23, Iss 1, Pp 1-14 (2021)
Abstract Background Breast cancer is a highly heterogeneous disease with multiple drivers and complex regulatory networks. Periostin (Postn) is a matricellular protein involved in a plethora of cancer types and other diseases. Postn has been shown to
Externí odkaz:
https://doaj.org/article/9c9e5ccf6503486ea9f67bb494f2c5be
Autor:
Khalid N. Al-Zahrani, John Abou-Hamad, Julia Pascoal, Cédrik Labrèche, Brennan Garland, Luc A. Sabourin
Publikováno v:
Breast Cancer Research, Vol 23, Iss 1, Pp 1-13 (2021)
Abstract Background Approximately 5–10% of HER2-positive breast cancers can be defined by low expression of the Ste20-like kinase, SLK, and high expression of SOX10. Our lab has observed that genetic deletion of SLK results in the induction of Sox1
Externí odkaz:
https://doaj.org/article/6a9ce1337d9a477fa45fa0766a28d362
Autor:
Khalid N. Al-Zahrani, John Abou-Hamad, Julia Pascoal, Cédrik Labrèche, Brennan Garland, Luc A. Sabourin
Publikováno v:
Breast Cancer Research, Vol 23, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/36d6a3be31bd4ba6b1ecff6a32ff164a
Autor:
Jonathan J. Hodgins, John Abou-Hamad, Ash Hagerman, Edward Yakubovich, Christiano Tanese de Souza, Marie Marotel, Ariel Buchler, Saleh Fadel, Maria M. Park, Claire Fong-McMaster, Mathieu F. Crupi, John C. Bell, Mary-Ellen Harper, Benjamin H. Rotstein, Rebecca C. Auer, Barbara C. Vanderhyden, Luc A. Sabourin, Marie-Claude Bourgeois-Daigneault, David P. Cook, Michele Ardolino
Targeting the PD-1/PD-L1 axis has transformed the field of immune-oncology. While conventional wisdom initially postulated that PD-L1 serves as the inert ligand for PD-1, an emerging body of literature suggests that PD-L1 has cell-intrinsic functions
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f1a75c947049681a8f0fcf1c901c4543
https://doi.org/10.1101/2022.08.31.506095
https://doi.org/10.1101/2022.08.31.506095
Autor:
Jonathan J. Hodgins, David P. Cook, Cédrik Labrèche, Benjamin R. Pryce, Michele Ardolino, John Abou-Hamad, Pascale Robineau-Charette, Luc A. Sabourin, Barbara C. Vanderhyden, Khalid N. Al-Zahrani, Rebecca C. Auer, John C. Bell, Christiano Tanese de Souza
Publikováno v:
Oncogene. 39:4592-4602
HER2 is overexpressed in 20–30% of all breast cancers and is associated with an invasive disease and poor clinical outcome. The Ste20-like kinase (SLK) is activated downstream of HER2/Neu and is required for efficient epithelial-to-mesenchymal tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2cc4676984bf021acddb906daf74fe3e
https://doi.org/10.1038/s41388-020-1315-3
https://doi.org/10.1038/s41388-020-1315-3
Autor:
Luc A. Sabourin, Ben Pryce, Christiano Tanese de Souza, John C. Bell, John Abou-Hamad, Michele Ardolino, Rebecca C. Auer, Daniel Schramek, Johnathan Hodgins, Cedrik Labreche, David P. Cook, Khalid N Al-Zahrani, Barbara C. Vanderhyden, Pascale Robineau-Charette
Publikováno v:
Cancer Research. 80:P2-04
Over the past two decades, the mammalian Ste20-like kinase (SLK) has been characterized for its role in regulating cellular migration, proliferation and apoptosis in fibroblasts and myoblasts. In mammary epithelial cells, SLK has been shown to be req
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e2e71fa12fed26b37593c0b683616e1
https://doi.org/10.1158/1538-7445.sabcs19-p2-04-05
https://doi.org/10.1158/1538-7445.sabcs19-p2-04-05
Autor:
Cédrik Labrèche, John Abou-Hamad, Khalid N. Al-Zahrani, Luc A. Sabourin, Julia Pascoal, Brennan Garland
Publikováno v:
Breast Cancer Research, Vol 23, Iss 1, Pp 1-13 (2021)
Breast Cancer Research : BCR
Breast Cancer Research : BCR
Background Approximately 5–10% of HER2-positive breast cancers can be defined by low expression of the Ste20-like kinase, SLK, and high expression of SOX10. Our lab has observed that genetic deletion of SLK results in the induction of Sox10 and sig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2abbe3e489e4718df02b795e2e7d755
https://doi.org/10.1186/s13058-021-01435-6
https://doi.org/10.1186/s13058-021-01435-6
Autor:
Cédrik Labrèche, Jérôme Frenette, Luc A. Sabourin, Benjamin R. Pryce, John Abou-Hamad, Antoine Boulanger-Piette, Dounia Hamoudi, Khalid N. Al-Zahrani, Cindy Balog-Alvarez, Jonathan J. Hodgins, Michele Ardolino, Sabrina Bossé, Joe N. Kornegay
Publikováno v:
Biochimica et biophysica acta. Molecular cell research. 1868(2)
Duchenne's muscular dystrophy (DMD) is a severe muscle wasting disorder characterized by the loss of dystrophin expression, muscle necrosis, inflammation and fibrosis. Ongoing muscle regeneration is impaired by persistent cytokine stress, further dec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc31a1dfee7cad418cf3c6ffc0a678a5
https://pubmed.ncbi.nlm.nih.gov/33259860
https://pubmed.ncbi.nlm.nih.gov/33259860