Zobrazeno 1 - 10
of 27
pro vyhledávání: '"John Abernethy"'
Autor:
Mihai Cernea, Georgiy Nikonov, Janna Ataiants, Cristina Ştefănuţ, John Abernethy, Michael Voronkov
Publikováno v:
Pharmaceuticals, Vol 17, Iss 7, p 866 (2024)
Developing an effective antidote for fentanyl-induced overdose to achieve timely reversal is an unmet public health need. Previously, we found that naloxone derivative NX90 with mild κ-opioid agonistic properties was three-fold more effective than t
Externí odkaz:
https://doaj.org/article/49b8a1bad02c41ab9a00f1b8d709a406
Autor:
John Abernethy, Aicacia Young, Sarah S. Bubeck, Kiran Krishnan, Sayed Yossef, Frances Clark, Thomas F. Bayne
Publikováno v:
Evidence-Based Complementary and Alternative Medicine, Vol 2020 (2020)
Background. Hepatic encephalopathy often results in high blood ammonia levels because of inefficient ammonia processing by the liver. Lactulose treatment promotes the growth of urease-producing gut bacteria and a reduced colon pH, thus reducing blood
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c3db4f6f712a8b022775fd79484d4e5
https://doi.org/10.1155/2020/1463108
https://doi.org/10.1155/2020/1463108
Publikováno v:
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 159
Developing non-addictive and safer opioids for pain management is unmet medical need. Among a number of bioreversible derivatives of Nalbuphine - an equipotent to morphine opioid without serious side effects - NB-33 was identified in silico and confi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::723bc42d7c8c6a3643411dd6f272e744
https://pubmed.ncbi.nlm.nih.gov/33515698
https://pubmed.ncbi.nlm.nih.gov/33515698
Autor:
Cristina Stefanut, M. Cernea, Levon Isakulyan, Georgiy Nikonov, Michael Voronkov, Janna Ataiants, John Abernethy
Publikováno v:
International Journal of Pharmaceutics. 611:121326
Developing an effective antidote for fentanyl-induced overdose (OD) is an unmet medical need that requires both lipophilicity comparable to fentanyl and fast onset of overdose reversal. We synthesized and evaluated a bioreversible derivative of nalox
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2effaceaa38f69cdd31b44f567ee0012
https://doi.org/10.1016/j.ijpharm.2021.121326
https://doi.org/10.1016/j.ijpharm.2021.121326
Autor:
Sayed, Yossef, Frances, Clark, Sarah S, Bubeck, John, Abernethy, Thomas, Bayne, Kiran, Krishnan, Aicacia, Young
Publikováno v:
Evidence-based Complementary and Alternative Medicine : eCAM
Background Hepatic encephalopathy often results in high blood ammonia levels because of inefficient ammonia processing by the liver. Lactulose treatment promotes the growth of urease-producing gut bacteria and a reduced colon pH, thus reducing blood
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cda1d192a63b4b7816be489dc1b09c85
https://pubmed.ncbi.nlm.nih.gov/32714397
https://pubmed.ncbi.nlm.nih.gov/32714397
Autor:
Richard J. Wenstrup, Jennifer Saam, John Abernethy, Heidi McCoy, Kelsey Moyes, Lavania Sharma, Michelle Landon
Publikováno v:
Cancer Research. 75:P4-12
Introduction: With the advancements of next generation sequencing, patients with a personal and/or family history of cancer that may not be suggestive of one cancer syndrome may be offered testing for mutations in multiple cancer-predisposing genes s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf53ca5bf6cfe78d1e05f546a84297cb
https://doi.org/10.1158/1538-7445.sabcs14-p4-12-02
https://doi.org/10.1158/1538-7445.sabcs14-p4-12-02
Autor:
John, Abernethy
Publikováno v:
Medical Facts and Observations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bfc16f3cd683f24a0a5777daa2057c0f
https://pubmed.ncbi.nlm.nih.gov/29106251
https://pubmed.ncbi.nlm.nih.gov/29106251
Autor:
John, Abernethy
Publikováno v:
Medical Facts and Observations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b81d2bc52cd6f702c861dd9eafe3bff5
https://pubmed.ncbi.nlm.nih.gov/29106224
https://pubmed.ncbi.nlm.nih.gov/29106224
Autor:
James S. Wing, Wen Li Bai, Carrie B. Wilson, Sarah Bass, Cedric Hunter, Paul D. Brewer-Jensen, Lillie L. Searles, John Abernethy, Yung Shu Kuan
Publikováno v:
Molecular and Cellular Biology. 29:5590-5603
RNA-binding proteins act at various stages of gene expression to regulate and fine-tune patterns of mRNA accumulation. One protein in this class is Drosophila Su(s), a nuclear protein that has been previously shown to inhibit the accumulation of muta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd2cc54013e03ec22b8f4b67ed8c578f
https://doi.org/10.1128/mcb.00039-09
https://doi.org/10.1128/mcb.00039-09
Autor:
John Abernethy, Shashi M Ariyanayagam-Baksh, Patricia A. Swalsky, Sydney D. Finkelstein, E. Leon Barnes, Fabien K Baksh
Publikováno v:
The American Journal of Dermatopathology. 25:21-27
Malignant blue nevus is a rare melanocytic tumor that is described by some authors as a variant of malignant melanoma, whereas others regard it as a distinct entity. To our knowledge no molecular studies of this tumor have been performed, although th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee572e14b151343f989ec0ea413c293c
https://doi.org/10.1097/00000372-200302000-00005
https://doi.org/10.1097/00000372-200302000-00005