Zobrazeno 1 - 10
of 60
pro vyhledávání: '"John A. Ulrich"'
Autor:
David W. Frederick, Alan V. McDougal, Melisa Semenas, Johanna Vappiani, Andrea Nuzzo, John C. Ulrich, J. David Becherer, Frank Preugschat, Eugene L. Stewart, Daniel C. Sévin, H. Fritz Kramer
Publikováno v:
Skeletal Muscle, Vol 10, Iss 1, Pp 1-14 (2020)
Abstract Background Duchenne muscular dystrophy (DMD) is a progressive muscle wasting disorder stemming from a loss of functional dystrophin. Current therapeutic options for DMD are limited, as small molecule modalities remain largely unable to decre
Externí odkaz:
https://doaj.org/article/b04d4dfb479846a2b8a0cd173136a2f2
Publikováno v:
Essays on Politics and Society ISBN: 9780520387928
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::11371f42ff8c1119f6c2e2d7352330a1
https://doi.org/10.1525/9780520387928-002
https://doi.org/10.1525/9780520387928-002
Autor:
Shian-Huey Chiang, W Wallace Harrington, Guizhen Luo, Naphtali O Milliken, John C Ulrich, Jing Chen, Deepak K Rajpal, Ying Qian, Tiffany Carpenter, Rusty Murray, Robert S Geske, Stephen A Stimpson, Henning F Kramer, Curt D Haffner, J David Becherer, Frank Preugschat, Andrew N Billin
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0134927 (2015)
Nicotinamide adenine dinucleotide (NAD+) is a key cofactor required for essential metabolic oxidation-reduction reactions. It also regulates various cellular activities, including gene expression, signaling, DNA repair and calcium homeostasis. Intrac
Externí odkaz:
https://doaj.org/article/6c250288d3cf48f0b41fe25918c4ad63
Autor:
David Frederick, Alan V. McDougal, Melisa Semenas, Johanna Vappiani, Andrea Nuzzo, John C. Ulrich, Eugene L. Stewart, Daniel C. Sévin, H. Fritz Kramer
Background Duchenne muscular dystrophy (DMD) is a progressive muscle wasting disorder stemming from a loss of functional dystrophin. Current therapeutic options for DMD are limited, as small molecule modalities remain largely unable to lessen the inc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::21136c34e5f1b7bb25b07f869525d926
https://doi.org/10.21203/rs.3.rs-28529/v1
https://doi.org/10.21203/rs.3.rs-28529/v1
Autor:
Brad R. Henke, Eugene L. Stewart, John C. Ulrich, Curt D. Haffner, J. Darren Stuart, David N. Deaton, Barry G. Shearer, Michael R. Jeune
Publikováno v:
Bioorganic & Medicinal Chemistry. 26:2107-2150
Starting from 4-amino-8-quinoline carboxamide lead 1a and scaffold hopping to the chemically more tractable quinazoline, a systematic exploration of the 2-substituents of the quinazoline ring, utilizing structure activity relationships and conformati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4fe7d9fc18b7c59f1ff4036d5152e6c
https://doi.org/10.1016/j.bmc.2018.03.021
https://doi.org/10.1016/j.bmc.2018.03.021
Autor:
Anthony L. Handlon, Lisa M. Leesnitzer, Joseph Wendell Wilson, Rodolfo Cadilla, Philip Stewart Turnbull, Chuck Poole, Raymond V. Merrihew, Lee T. Schaller, John C. Ulrich
Publikováno v:
ACS Medicinal Chemistry Letters. 7:83-88
A series of selective androgen receptor modulators (SARMs) containing the 1-(trifluoromethyl)benzyl alcohol core have been optimized for androgen receptor (AR) potency and drug-like properties. We have taken advantage of the lipophilic ligand efficie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1948a5cc793f5e6af8fe972330e13665
https://doi.org/10.1021/acsmedchemlett.5b00377
https://doi.org/10.1021/acsmedchemlett.5b00377
Autor:
John M. Ulrich
Publikováno v:
Pedagogy. 13:3-7
English programs like mine face a particular challenge: implementing a manageable assessment process in an institutional context featuring scarce resources, staff reductions, and heavy teaching loads. We believe our portfolio-based process enables us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::825a13f6629a847e21351baa277285e5
https://doi.org/10.1215/15314200-1814152
https://doi.org/10.1215/15314200-1814152
Autor:
John M. Ulrich
Publikováno v:
Studies in the Literary Imagination. 45:67-87
The speaking classes speak and debate, each for itself; the great dumb, deep-buried class lies like an Enceladus, who in his pain, if he will complain of it, has to produce earthquakes! --Carlyle, Chartism (215) Thomas Carlyle's long essay Chartism w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::617bb9f20bd44a56c30e330066c35538
https://doi.org/10.1353/sli.2012.0001
https://doi.org/10.1353/sli.2012.0001
Autor:
Chuck Poole, Pierette Banker, Yu Guo, Gregory Schaaf, Tiffany Carpenter, Stephen A. Thomson, Dan Gillie, Curt D. Haffner, John C. Ulrich, Scott Howard Dickerson, Petrov Kimberly, J. Patrick Condreay, Jeff Gobel, Andrew L. Larkin
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:6989-6992
We report the synthesis and in vitro activity of a series of novel substituted N-{3-[(1,1-dioxido-1,2-benzothiazol-3-yl)(phenyl)amino]propyl}benzamide analogs. These analogs showed potent inhibitory activity against Kv1.3. Several demonstrated simila
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e446dcc67f45aee64239596e8f347acb
https://doi.org/10.1016/j.bmcl.2010.09.131
https://doi.org/10.1016/j.bmcl.2010.09.131
Autor:
Adam Ashe, Thomas B. Stanley, Todd W Shearer, Craig D. Wagner, John C. Ulrich, Lisa M. Leesnitzer, Barry G. Shearer, Raymond V. Merrihew, Robert W. Wiethe, James M. Way, Robert X. Xu, Andrew N. Billin, Timothy M. Willson, Michael R. Jeune
Publikováno v:
Journal of Medicinal Chemistry. 53:1857-1861
4-Chloro-N-(2-{[5-trifluoromethyl)-2-pyridyl]sulfonyl}ethyl)benzamide 3 (GSK3787) was identified as a potent and selective ligand for PPARdelta with good pharmacokinetic properties. A detailed binding study using mass spectral analysis confirmed cova
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8984378fd8ba14814739549a07608292
https://doi.org/10.1021/jm900464j
https://doi.org/10.1021/jm900464j