Zobrazeno 1 - 10
of 77
pro vyhledávání: '"John A. Timbrell"'
Autor:
John A. Timbrell
Publikováno v:
Target Organ Toxicity ISBN: 9780429288845
The liver is exposed to many potentially toxic substances and is frequently a target organ in experimental animal studies. By its position, structure, and biochemistry, the liver is especially vulnerable to damage from toxic compounds. However, in ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b71bc5a43d4c3e6ba21f3b1c357838e6
https://doi.org/10.1201/9780429288845-8
https://doi.org/10.1201/9780429288845-8
Autor:
John A. Timbrell, George Fotakis
Publikováno v:
Environmental Toxicology and Pharmacology. 22:334-337
The aim of this study was to investigate the effect of individual sulfur amino acid deprivation in cadmium chloride toxicity. HTC cells were deprived of cystine and/or methionine for 12h and then exposed to CdCl(2) for 12h. HepG2 cells were deprived
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6bee857cbde00f1f31d5aa11a195f55
https://doi.org/10.1016/j.etap.2006.04.006
https://doi.org/10.1016/j.etap.2006.04.006
Autor:
George Fotakis, John A. Timbrell
Publikováno v:
Toxicology Letters. 164:97-103
Cadmium coexists with other metals in various products. Releases of cadmium in the environment occur in parallel to the release of other metals including copper, iron and zinc which also have an essential role in human homeostasis as they participate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33fde65687a6fd8c7a7c3887f0a5ba98
https://doi.org/10.1016/j.toxlet.2005.11.016
https://doi.org/10.1016/j.toxlet.2005.11.016
Publikováno v:
Phytotherapy Research. 19:870-875
The cytotoxicity of extracts from a widely used species of plant, Moringa stenopetala, was assessed in HEPG2 cells, by measuring the leakage of lactate dehydrogenase (LDH) and cell viability. The functional integrity of extract-exposed cells was dete
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cebeaa767e24e99d7b39ede427110260
https://doi.org/10.1002/ptr.1720
https://doi.org/10.1002/ptr.1720
Publikováno v:
Toxicology in Vitro. 14:169-176
Stress protein induction has been advocated as a sensitive indicator of compound-induced toxicity. In monolayer cultures of primary hepatocytes, however, the two stress proteins, Hsp25 and Hsp72/3 are up-regulated, probably due to the effect of the i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebf1ea3f73376736ef1a98bca98fdadd
https://doi.org/10.1016/s0887-2333(00)00002-3
https://doi.org/10.1016/s0887-2333(00)00002-3
Autor:
Daniel S. Asker, Susan H. Kenyon, John A. Timbrell, Mita D. J. Kerai, Catherine J. Waterfield
Publikováno v:
Amino Acids. 15:53-76
Alcohol was administered chronically to female Sprague Dawley rats in a nutritionally adequate totally liquid diet for 28 days. This resulted in hepatic steatosis and lipid peroxidation. Taurine, when co-administered with alcohol, reduced the hepatic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad74d4ffca43242b32f230ba87f0cdd1
https://doi.org/10.1007/bf01345280
https://doi.org/10.1007/bf01345280
Publikováno v:
Amino Acids. 15:161-177
Changes in urinary levels of taurine have been reported in rats following treatment with various xenobiotics including those which alter protein synthesis and/or are hepatotoxic. This paper reports on the time course of the urinary elevation of tauri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::329cbfb974fd7b01be6cd340728268b5
https://doi.org/10.1007/bf01345289
https://doi.org/10.1007/bf01345289
Publikováno v:
Amino Acids. 15:13-25
The administration of a single subcutaneous dose of clenbuterol to rats altered the level of taurine in certain tissues. Taurine levels in cardiac tissue were significantly decreased 3 h after the administration of 250 micrograms/kg of clenbuterol an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1547172f2175a1266f28e00ec341fa2b
https://doi.org/10.1007/bf01345277
https://doi.org/10.1007/bf01345277
Autor:
Ruth P. Draper, John A. Timbrell
Publikováno v:
Biomarkers. 3:335-346
In this study, biomarkers of testicular damage were compared. In particular, urinary creatine was evaluated as a non-invasive marker of damage. Male rats were exposed to various doses of cadmium chloride, an established testicular toxicant. Pathologi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::291d1aa8fd7b8f151a6e1d2653bf9abe
https://doi.org/10.1080/135475098231147
https://doi.org/10.1080/135475098231147
Publikováno v:
Chemico-Biological Interactions. 107:157-172
Treatment of animals with hydrazine causes the accumulation of triglycerides in the liver but the mechanism remains unclear. Therefore, the effect of hydrazine on hepatic triglyceride synthesis and subsequent transport was studied in a hepatocyte mod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ae6fc17e2ac594c8d5c8359cb1f079a
https://doi.org/10.1016/s0009-2797(97)00090-2
https://doi.org/10.1016/s0009-2797(97)00090-2