Zobrazeno 1 - 10
of 26
pro vyhledávání: '"John A. Shupe"'
Autor:
F. Christopher Peritore-Galve, Izumi Kaji, Anna Smith, Lauren M. Walker, John A. Shupe, M. Kay Washington, Holly M. Scott Algood, Pradeep K. Dudeja, James R. Goldenring, D. Borden Lacy
Publikováno v:
Gut Microbes, Vol 15, Iss 1 (2023)
ABSTRACTBackground & Aim Clostridioides difficile infection (CDI) is the leading cause of hospital-acquired diarrhea and pseudomembranous colitis. Two protein toxins, TcdA and TcdB, produced by C. difficile are the major determinants of disease. Howe
Externí odkaz:
https://doaj.org/article/24d8cbb83eb34a299947e37b96105dfe
Autor:
Hannah M. Lunnemann, Nicolas G. Shealy, Michelle L. Reyzer, John A. Shupe, Emily H. Green, Uswah Siddiqi, D. Borden Lacy, Mariana X. Byndloss, Nicholas O. Markham
Publikováno v:
Gut Microbes, Vol 15, Iss 1 (2023)
ABSTRACTThe mouse cecum has emerged as a model system for studying microbe-host interactions, immunoregulatory functions of the microbiome, and metabolic contributions of gut bacteria. Too often, the cecum is falsely considered as a uniform organ wit
Externí odkaz:
https://doaj.org/article/cf947e7888d24002ac4d1f911649f213
Autor:
F Christopher Peritore-Galve, John A Shupe, Rory J Cave, Kevin O Childress, M Kay Washington, Sarah A Kuehne, D Borden Lacy
Publikováno v:
PLoS Pathogens, Vol 18, Iss 2, p e1010323 (2022)
Clostridioides difficile infection (CDI) is the leading cause of nosocomial diarrhea and pseudomembranous colitis in the USA. In addition to these symptoms, patients with CDI can develop severe inflammation and tissue damage, resulting in life-threat
Externí odkaz:
https://doaj.org/article/53681cccf54a48f9aac596fac3673cfc
Autor:
F. Christopher Peritore-Galve, Izumi Kaji, Anna Smith, Lauren M. Walker, John A. Shupe, Pradeep K. Dudeja, James R. Goldenring, D. Borden Lacy
Background & AimClostridioides difficileinfection (CDI) is the leading cause of hospital-acquired diarrhea and pseudomembranous colitis. Two protein toxins, TcdA and TcdB, produced byC. difficileare the major determinants of disease. However, the phy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9add9080d8b786eb0788224067387ad
https://doi.org/10.1101/2022.11.12.516162
https://doi.org/10.1101/2022.11.12.516162
Autor:
Dena Lyras, John A. Shupe, Jaime L. Jensen, Michael J Sheedlo, Ashleigh P. Rogers, Sarah C. Bloch, Steven J. Mileto, Melanie L. Hutton, Simon Wilkins, Kevin O. Childress, Genevieve Kerr, D. Borden Lacy, Rebekah Engel, Paul J. McMurrick, Thierry Jarde, Katja Horvay, Tracey J. Flores, Helen E. Abud
Publikováno v:
Proc Natl Acad Sci U S A
Gastrointestinal infections often induce epithelial damage that must be repaired for optimal gut function. While intestinal stem cells are critical for this regeneration process [R. C. van der Wath, B. S. Gardiner, A. W. Burgess, D. W. Smith, PLoS On
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e63a59301301e5ccaa8a9f1761b473d4
https://doi.org/10.1073/pnas.1915255117
https://doi.org/10.1073/pnas.1915255117
Autor:
F. Christopher Peritore-Galve, Audrey K. Thomas, Heather K. Kroh, John A. Shupe, M. Kay Washington, Sarah C. Bloch, Erin N. Laubacher, D. Borden Lacy, Kevin O. Childress, Robert J. Coffey, Nicholas O. Markham
Publikováno v:
Infection and Immunity. 89
Clostridioides difficile is linked to nearly 225,000 antibiotic-associated diarrheal infections and almost 13,000 deaths per year in the United States. Pathogenic strains of C. difficile produce toxin A (TcdA) and toxin B (TcdB), which can directly k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fdd395deb9860a8157017ce04d07c27d
https://doi.org/10.1128/iai.00543-20
https://doi.org/10.1128/iai.00543-20
Autor:
Nicholas O. Markham, Erin N. Laubacher, D. Borden Lacy, John A. Shupe, M. Kay Washington, Sarah C. Bloch, Robert J. Coffey
Clostridioides difficile is linked to nearly 225,000 antibiotic-associated diarrheal infections and almost 13,000 deaths per year in the United States. Pathogenic strains of C. difficile produce toxin A (TcdA) and toxin B (TcdB), which can directly k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::61d0074737b0f94e59a641737f2b3c13
https://doi.org/10.1101/2020.08.30.274738
https://doi.org/10.1101/2020.08.30.274738
Autor:
Nicholas O, Markham, Sarah C, Bloch, John A, Shupe, Erin N, Laubacher, Audrey K, Thomas, Heather K, Kroh, Kevin O, Childress, F Christopher, Peritore-Galve, M Kay, Washington, Robert J, Coffey, D Borden, Lacy
Publikováno v:
Infect Immun
Clostridioides difficile is linked to nearly 225,000 antibiotic-associated diarrheal infections and almost 13,000 deaths per year in the United States. Pathogenic strains of C. difficile produce toxin A (TcdA) and toxin B (TcdB), which can directly k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b8d82289e996b44c13295aade81ef64e
https://pubmed.ncbi.nlm.nih.gov/33468584
https://pubmed.ncbi.nlm.nih.gov/33468584
Autor:
McKenzie King, Melissa A. Farrow, Benjamin W. Spiller, John A. Shupe, Sarah C. Bloch, Kaycei Moton-Melancon, Nicole M. Chumber, D. Borden Lacy, Mary Kay Washington
Publikováno v:
ACS Chem Biol
Clostridioides difficile is the leading cause of nosocomial diarrhea in the United States. The primary virulence factors are two homologous sglucosyltransferase toxins, TcdA and TcdB, that inactivate host Rho-family GTPases. The glucosyltransferase a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc73c87bf52e2809cf36861a6dc889f9
https://europepmc.org/articles/PMC7230009/
https://europepmc.org/articles/PMC7230009/
Autor:
M. Kay Washington, Eric P. Skaar, Richard M. Caprioli, William N. Beavers, John A. Shupe, Jeffrey M. Spraggins, Aaron G. Wexler, Emma R. Guiberson, D. Borden Lacy
Publikováno v:
Cell reports
SUMMARY Clostridioides difficile is the leading cause of nosocomial intestinal infections in the United States. Ingested C. difficile spores encounter host bile acids and other cues that are necessary for germinating into toxin-producing vegetative c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2c8246cf12ad268ba019dc67394ed38
https://doi.org/10.1016/j.celrep.2021.109683
https://doi.org/10.1016/j.celrep.2021.109683