Zobrazeno 1 - 10
of 1 039
pro vyhledávání: '"John A. Price"'
Autor:
Ian Cooney, Heidi L. Schubert, Karina Cedeno, Olivia N. Fisher, Richard Carson, John C. Price, Christopher P. Hill, Peter S. Shen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract The Cdc48 AAA+ ATPase is an abundant and essential enzyme that unfolds substrates in multiple protein quality control pathways. The enzyme includes two conserved AAA+ ATPase motor domains, D1 and D2, that assemble as hexameric rings with D1
Externí odkaz:
https://doaj.org/article/b25688b846c6429888dd572ed559fd73
Autor:
Aled Daffyd Rees, Deborah P Merke, Wiebke Arlt, Aude Brac De La Perriere, Angelica Linden-Hirschberg, Anders Juul, John Newell-Price, Alessandro Prete, Nicole Reisch, Nike M Stikkelbroeck, Philippe A Touraine, Alex Lewis, John Porter, Helen Coope, Richard J Ross
Publikováno v:
Endocrine Connections, Vol 13, Iss 8, Pp 1-8 (2024)
Background: Prednisolone and prednisone are recommended treatment options for adults with congenital adrenal hyperplasia (CAH); however, there is no randomised comparison of prednis(ol)one with hydrocortisone. Design: Six-month open-label randomised
Externí odkaz:
https://doaj.org/article/9c082fbf1ccd444a90aea6c8d0fd6b11
Autor:
Ian Cooney, Heidi L. Schubert, Karina Cedeno, Olivia N. Fisher, Richard Carson, John C. Price, Christopher P. Hill, Peter S. Shen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/f5698796a7ff46d78f37a424e2ed9904
Autor:
Hiroshi Arima, Timothy Cheetham, Mirjam Christ-Crain, Deborah Cooper, Mark Gurnell, Juliana B Drummond, Miles Levy, Ann I McCormack, Joseph Verbalis, John Newell-Price, John A H Wass
Publikováno v:
Endocrine Connections, Vol 11, Iss 11, Pp 1-4 (2022)
‘What’s in a name? That which we call a rose/By any other name would smell as sweet’ (Juliet, from Romeo and Juliet by William Shakespeare). Shakespeare’s implication is that a name is nothing but a word, and it therefore represents a convent
Externí odkaz:
https://doaj.org/article/a0532482c3394a2caccb512e87e17c8f
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
The process of macroautophagy plays a pivotal role in the degradation of long-lived, superfluous, and damaged proteins and organelles, which are later recycled for cellular use. Normal cells rely on autophagy to combat various stressors and insults t
Externí odkaz:
https://doaj.org/article/f143fb008b054f0fa53e9abc9e6a633d
Autor:
Yang Xu, Han Han, Ian Cooney, Yuxuan Guo, Noah G. Moran, Nathan R. Zuniga, John C. Price, Christopher P. Hill, Peter S. Shen
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-8 (2022)
The p97 unfoldase is an essential and abundant enzyme that segregates its substrates from macromolecular complexes and organelle membranes. Here, authors determined the structure of human p97 in the act of unfolding an authentic substrate.
Externí odkaz:
https://doaj.org/article/2b0aaf042b8f4253a15fabdae3c83fbf
Autor:
Hsien-Jung L Lin, David H Parkinson, J Connor Holman, W Chad Thompson, Christian N K Anderson, Marcus Hadfield, Stephen Ames, Nathan R Zuniga Pina, Jared N Bowden, Colette Quinn, Lee D Hansen, John C Price
Publikováno v:
PLoS ONE, Vol 18, Iss 3, p e0271008 (2023)
Differential scanning calorimetry (DSC) can indicate changes in structure and/or concentration of the most abundant proteins in a biological sample via heat denaturation curves (HDCs). In blood serum for example, HDC changes result from either concen
Externí odkaz:
https://doaj.org/article/0b137c8322354b5ea4935bd6ca010054
Autor:
Natasha P. Sturre, Rhys N. Colson, Neelam Shah, Gabrielle M. Watson, Xue Yang, Matthew C. J. Wilce, John T. Price, Jacqueline A. Wilce
Publikováno v:
Biomedicines, Vol 10, Iss 5, p 1145 (2022)
The development of peptide inhibitors against intracellular targets depends upon the dual challenge of achieving a high affinity and specificity for the target and maintaining cellular permeability for biological activity. Previous efforts to develop
Externí odkaz:
https://doaj.org/article/69126f1703be444598e0709ac52cee14
Publikováno v:
Journal of Proteome Research. 22:605-614
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c90dd0d7bd5959b6034ff114ad235a5c
https://doi.org/10.1021/acs.jproteome.2c00619
https://doi.org/10.1021/acs.jproteome.2c00619
Autor:
Hsien-Jung L. Lin, Isabella James, Chad D. Hyer, Connor T. Haderlie, Michael J. Zackrison, Tyler M. Bateman, Monica Berg, Ji-Sun Park, S. Anisha Daley, Nathan R. Zuniga Pina, Yi-Jie J. Tseng, James D. Moody, John C. Price
Publikováno v:
Journal of Proteome Research. 21:2920-2935
Many of the diseases that plague society today are driven by a loss of protein quality. One method to quantify protein quality is to measure the protein folding stability (PFS). Here, we present a novel mass spectrometry (MS)-based approach for PFS m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2064cf7b4f11fa44803d914341105244
https://doi.org/10.1021/acs.jproteome.2c00323
https://doi.org/10.1021/acs.jproteome.2c00323