Výsledky vyhledávání - "John A. McLane"

Akademický článek

Pharmacokinetic and pharmacodynamic comparison of subcutaneous intramuscular leuprolide acetate formulations in male subjects

Autor: Daniel Saltzstein, Neal D. Shore, Judd W. Moul, Franklin Chu, Raoul Concepcion, Stephan de la Motte, John A. McLane, Stuart Atkinson, Alex Yang, E. David Crawford

Publikováno v: Therapeutic Advances in Urology, Vol 10 (2018)

Background: The aim of this study was to compare the pharmacokinetics (PK) and pharmacodynamics (PD) of two distinct formulations of leuprolide acetate (LA); subcutaneous (SC) injection and intramuscular (IM) injection. Methods: A total of 32 healthy

Externí odkaz: https://doaj.org/article/5166418b3882422f949c3a7bd2933c8c

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Pharmacokinetic and pharmacodynamic comparison of subcutaneous versus intramuscular leuprolide acetate formulations in male subjects

Autor: Alex Yang, Raoul S. Concepcion, Stephan de la Motte, Judd W. Moul, Stuart Atkinson, Daniel Saltzstein, Neal D. Shore, E. David Crawford, Franklin Chu, John A. McLane

Publikováno v: Therapeutic Advances in Urology, Vol 10 (2018)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b8c80697b5d17c4361e1c8b902fcfe3
https://europepmc.org/articles/PMC5805007/

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BPI19-009: Late Administration of Luteinizing Hormone-Releasing Hormone (LHRH) Agonists and Testosterone Levels >50NG/DL in Prostate Cancer

Autor: Eleni Efstathiou, Deborah M. Boldt-Houle, Stuart Atkinson, Raoul S. Concepcion, John A. McLane

Publikováno v: Journal of the National Comprehensive Cancer Network. 17:BPI19-009

Background: Achieving and maintaining effective testosterone (T) suppression is key to treatment of advanced prostate cancer (PCa), for which LHRH agonists are standard of care. Increasing evidence suggests maintaining very low T levels to Methods: A

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9c6f476b6a7de648edcceb0d15666699
https://doi.org/10.6004/jnccn.2018.7204

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Late administration of luteinizing hormone-releasing hormone (LHRH) agonists and the impact on testosterone suppression in the real-world management of prostate cancer

Autor: Scott T. Tagawa, Stuart Atkinson, Przemyslaw Twardowski, John A. McLane, Debbie Boldt-Houle, A. Oliver Sartor

Publikováno v: Journal of Clinical Oncology. 37:149-149

149 Background: LHRH agonists are standard for androgen deprivation therapy (ADT) for advanced prostate cancer (PCa). Increasing evidence suggests maintaining very low testosterone (T) levels is desirable and correlate with disease-specific survival.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::69c363cb69129da8aa6404e586eb26a0
https://doi.org/10.1200/jco.2019.37.7_suppl.149

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Low incidence of microsurges with biodegradable polymer-delivered, subcutaneously-administered leuprolide acetate in prostate cancer patients

Autor: John A. McLane, Stuart Atkinson, Eleni Efstathiou, Debbie Boldt-Houle, A. Oliver Sartor

Publikováno v: Journal of Clinical Oncology. 37:158-158

158 Background: Androgen deprivation therapy is a foundational treatment of advanced prostate cancer (PCa) with the primary objective of suppressing circulating androgens.Consistent drug delivery with long-acting leuprolide acetate (LA) formulations

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9b113156a38d550e07a1a95b90373b65
https://doi.org/10.1200/jco.2019.37.7_suppl.158

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Paradise Locked: The 1918 Influenza Pandemic in American Samoa

Autor: John Ryan McLane

Publikováno v: Sites: a journal of social anthropology and cultural studies. 10:30-51

The 1918 influenza pandemic killed roughly 5% of the global population. In Polynesia death rates were greater, reaching as high as a quarter of inhabitants in Western Samoa. Despite being less than 100km from the disaster in Western Samoa, and despit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6d93318c5730daf26336d4e576a4e84b
https://doi.org/10.11157/sites-vol10iss2id215

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Polymer-delivered subcutaneous leuprolide acetate formulations achieve and maintain castrate concentrations of testosterone in four open-label studies in patients with advanced prostate cancer

Autor: Judd W. Moul, Neal D. Shore, Stuart Atkinson, John A. McLane, Daniel Saltzstein, Franklin Chu, E. David Crawford, Raoul S. Concepcion, Alex Yang

Publikováno v: BJU international. 119(2)

Objective To determine whether luteinising hormone-releasing hormone (LHRH) agonist, ATRIGEL® polymer-delivered, subcutaneous, leuprolide acetate (ADSC-LA), formulations suppressed serum testosterone to concentrations of ≤20 ng/dL. Patients and Me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f6bc3f1d1d256504c7adbcb926e83f7
https://pubmed.ncbi.nlm.nih.gov/32349187

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Onset and maintenance of testosterone suppression in four pivotal trials of subcutaneously administered leuprolide acetate formulated with in-situ forming polymeric delivery technology

Autor: Stuart Atkinson, John A. McLane, Przemyslaw Twardowski, A. Oliver Sartor, Debbie Boldt-Houle

Publikováno v: Journal of Clinical Oncology. 36:205-205

205 Background: Subcutaneously administered leuprolide acetate (SC-LA) formulated with in-situ forming polymeric delivery technology has demonstrated efficacy in suppressing testosterone (T) levels to achieve and maintain medical castration in patien

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bbb626b197fadb80446064f9e5f93faa
https://doi.org/10.1200/jco.2018.36.6_suppl.205

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Testosterone (T) suppression by weight and age groups in four pivotal trials of in-situ forming polymer-delivered, subcutaneously administered leuprolide acetate in men with prostate cancer (PCa)

Autor: Scott T. Tagawa, A. Oliver Sartor, Debbie Boldt-Houle, John A. McLane, Stuart Atkinson

Publikováno v: Journal of Clinical Oncology. 36:172-172

172 Background: In-situ forming polymer-delivered, subcutaneous leuprolide acetate (SC-LA) has previously been shown to suppress serum T levels to ≤20ng/dL in advanced PCa patients. Currently, luteinizing hormone releasing hormone agonists are dose

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c0c50516d66bbfd1ad695bb077d8f2f4
https://doi.org/10.1200/jco.2018.36.6_suppl.172

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