Zobrazeno 1 - 10
of 54
pro vyhledávání: '"John A. Masucci"'
Autor:
Fang Liu-Walsh, John A. Masucci, James E. Hauschild, Gregory C Leo, Kimberly A. Capone, Allison Rush, Neena K. Tierney
Publikováno v:
Clinical, Cosmetic and Investigational Dermatology
Fang Liu-Walsh,1 Neena K Tierney,1 James Hauschild,2 Allison K Rush,1 John Masucci,3 Gregory C Leo,3 Kimberly A Capone1 1Johnson & Johnson Consumer Inc., Skillman, NJ, USA; 2Johnson & Johnson Microbiological Quality & Sterility Assurance, Johnson & J
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4eca92dd3acb68d27da534ed0b88806d
https://doi.org/10.2147/ccid.s253386
https://doi.org/10.2147/ccid.s253386
Autor:
Michael N. Greco, John A. Masucci, William V. Murray, Tonya Le Blanc, Wensheng Lang, Mark J. Macielag, Yue-Mei Zhang, Jack Kauffman, Keith T. Demarest
Publikováno v:
ACS Medicinal Chemistry Letters. 11:2504-2509
The 6-benzhydryl-4-amino-quinolin-2-ones are peripherally restricted CB1 receptor inverse agonists (CB1RIAs) that have been reported to attenuate obesity and improve insulin sensitivity in the diet-induced obese (DIO) mouse model. However, chronic do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d7c1b7345b95fcf97988d40c64f0712
https://doi.org/10.1021/acsmedchemlett.0c00495
https://doi.org/10.1021/acsmedchemlett.0c00495
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports
Scientific Reports
There is a long-standing concern for the lack of reproducibility of the untargeted metabolomic approaches used in pharmaceutical research. Two types of human plasma samples were split into two batches and analyzed in two individual labs for untargete
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::324d9823bd228fc7b4ce85164bcb41bb
http://link.springer.com/article/10.1038/s41598-020-67939-x
http://link.springer.com/article/10.1038/s41598-020-67939-x
Publikováno v:
Methods in Pharmacology and Toxicology ISBN: 9781071615416
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c289a52bb73f4e7bcb0c26fff3b686c5
https://doi.org/10.1007/978-1-0716-1542-3_20
https://doi.org/10.1007/978-1-0716-1542-3_20
Publikováno v:
Methods in Pharmacology and Toxicology ISBN: 9781071615416
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23342686815e9b05a2ea86b4e8e5c89c
https://doi.org/10.1007/978-1-0716-1542-3_22
https://doi.org/10.1007/978-1-0716-1542-3_22
Publikováno v:
Methods in Pharmacology and Toxicology ISBN: 9781071615416
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e8bf25630fd6fe9ee442a69d1f523d65
https://doi.org/10.1007/978-1-0716-1542-3_21
https://doi.org/10.1007/978-1-0716-1542-3_21
Autor:
Robyn L. Miller, Gee-Hong Kuo, Keli Dzordzorine, Alessandro Pocai, Michael David Gaul, Margery A. Connelly, Seunghun Paul Lee, Ioanna Petrounia, Geoffrey Struble, Wensheng Lang, Gary W. Caldwell, Jennifer Kirkpatrick, John A. Masucci, Alexander N. Barnakov, Jenson Qi
Publikováno v:
SLAS Discovery. 22:433-439
Monoacylglycerol acyltransferase enzymes (MGAT1, MGAT2, and MGAT3) convert monoacylglycerol to diacylglycerol (DAG). MGAT1 and MGAT2 are both implicated in obesity-related metabolic diseases. Conventional MGAT enzyme assays use radioactive substrates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66e68670b3cf30efb724ffae48a613bc
https://doi.org/10.1177/2472555217690101
https://doi.org/10.1177/2472555217690101
Publikováno v:
Current Topics in Medicinal Chemistry. 12:1282-1290
A major strategy used in drug design is the inhibition of enzyme activity. The ability to accurately measure the concentration of the inhibitor which is required to inhibit a given biological or biochemical function by half is extremely important in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dba1acdde1430b47eea517fbbd79a904
https://doi.org/10.2174/156802612800672844
https://doi.org/10.2174/156802612800672844
Publikováno v:
Current Topics in Medicinal Chemistry. 12:1243-1249
Determination of drug distribution in brain and other tissues is important in pharmaceutical research. Tissue drug levels need to be determined routinely as they are usually diagnostic for both efficacy and toxicity. Determination of tissue levels in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::840a0bc8867fcdcca993d11fd973bb1c
https://doi.org/10.2174/156802612800672916
https://doi.org/10.2174/156802612800672916
Autor:
Andrew D. Mahan, Stanley M. Belkowski, Lawrence de Garavilla, Jukka Kervinen, John A. Masucci, Matthew Olson, Michael R. D'Andrea
Publikováno v:
bchm. 389:1219-1224
Secretory leukocyte protease inhibitor (SLPI) is a protease inhibitor of the whey acidic protein-like family inhibiting chymase, chymotrypsin, elastase, proteinase 3, cathepsin G and tryptase. Performing in vitro enzymatic assays using both Western b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e99c480036f6d9e05684563d4aa594d
https://doi.org/10.1515/bc.2008.138
https://doi.org/10.1515/bc.2008.138