Vorinostat Improves Myotonic Dystrophy Type 1 Splicing Abnormalities in DM1 Muscle Cell Lines and Skeletal Muscle from a DM1 Mouse Model

Autor: Nafisa Neault, Aymeric Ravel-Chapuis, Stephen D. Baird, John A. Lunde, Mathieu Poirier, Emiliyan Staykov, Julio Plaza-Diaz, Gerardo Medina, Francisco Abadía-Molina, Bernard J. Jasmin, Alex E. MacKenzie

Publikováno v: International Journal of Molecular Sciences, Vol 24, Iss 4, p 3794 (2023)

Myotonic dystrophy type 1 (DM1), the most common form of adult muscular dystrophy, is caused by an abnormal expansion of CTG repeats in the 3′ untranslated region of the dystrophia myotonica protein kinase (DMPK) gene. The expanded repeats of the D

Externí odkaz: https://doaj.org/article/02248837f6264698937e8d5f53f3e0d8

Muscle-specific microRNA-206 targets multiple components in dystrophic skeletal muscle representing beneficial adaptations

Autor: Adel Amirouche, John A. Lunde, Vanessa E. Jahnke, Damien Freyssenet, Nathalie Koulmann, Bernard J. Jasmin

Publikováno v: American Journal of Physiology-Cell Physiology
American Journal of Physiology-Cell Physiology, 2017, 312 (3), pp.C209--C221. ⟨10.1152/ajpcell.00185.2016⟩

Over the last several years, converging lines of evidence have indicated that miR-206 plays a pivotal role in promoting muscle differentiation and regeneration, thereby potentially impacting positively on the progression of neuromuscular disorders, i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40d80786ee7aa3b732fc756a4e7c2d50
https://doi.org/10.1152/ajpcell.00185.2016

A reduction in the human adenovirus virion size through use of a shortened fibre protein does not enhance muscle transduction following systemic or localised delivery in mice

Autor: Lyndsay M. Murray, John A. Lunde, Rashmi Kothary, Emily McFall, Robin J. Parks, Bernard J. Jasmin

Publikováno v: Virology. :444-453

We have investigated whether reducing the overall size of adenovirus (Ad), through use of a vector containing a shortened fibre, leads to enhanced distribution and dissemination of the vector. Intravenous or intraperitoneal injection of Ad5SlacZ (12n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9975829ef53853cd4ffba358d41cc71

Ets-2 Repressor Factor Silences Extrasynaptic Utrophin by N-Box–mediated Repression in Skeletal Muscle

Autor: Bernard J. Jasmin, John A. Lunde, Olga Lozynska, Caroline Ketterer, Tejvir S. Khurana, Kelly J. Perkins, Utpal Basu, Neal A. Rubinstein, Murat T. Budak, Santhosh M. Baby

Publikováno v: Molecular Biology of the Cell. 18:2864-2872

Utrophin is the autosomal homologue of dystrophin, the protein product of the Duchenne's muscular dystrophy (DMD) locus. Utrophin expression is temporally and spatially regulated being developmentally down-regulated perinatally and enriched at neurom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a796bcb9be1b6fa244a2a0df9a62c804
https://doi.org/10.1091/mbc.e06-12-1069

The RNA-binding Protein HuR Binds to Acetylcholinesterase Transcripts andRegulates Their Expression in Differentiating Skeletal MuscleCells

Autor: Bernard J. Jasmin, John A. Lunde, Robin J. Parks, Guy Bélanger, James Mwanjewe, Julie Deschênes-Furry, Nora I. Perrone-Bizzozero

Publikováno v: Journal of Biological Chemistry. 280:25361-25368

During myogenic differentiation, acetylcholinesterase (AChE) transcript levels are known to increase dramatically. Although this increase can be attributed in part to increased transcriptional activity, posttranscriptional mechanisms have also been i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78484f37877dccdfa556b8aeea9e6e10
https://doi.org/10.1074/jbc.m410929200