Zobrazeno 1 - 10
of 274
pro vyhledávání: '"John A. Lees"'
Autor:
Ouli Xie, Jacqueline M. Morris, Andrew J. Hayes, Rebecca J. Towers, Magnus G. Jespersen, John A. Lees, Nouri L. Ben Zakour, Olga Berking, Sarah L. Baines, Glen P. Carter, Gerry Tonkin-Hill, Layla Schrieber, Liam McIntyre, Jake A. Lacey, Taylah B. James, Kadaba S. Sriprakash, Scott A. Beatson, Tadao Hasegawa, Phil Giffard, Andrew C. Steer, Michael R. Batzloff, Bernard W. Beall, Marcos D. Pinho, Mario Ramirez, Debra E. Bessen, Gordon Dougan, Stephen D. Bentley, Mark J. Walker, Bart J. Currie, Steven Y. C. Tong, David J. McMillan, Mark R. Davies
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Streptococcus dysgalactiae subsp. equisimilis (SDSE) is an emerging cause of human infection with invasive disease incidence and clinical manifestations comparable to the closely related species, Streptococcus pyogenes. Through systematic ge
Externí odkaz:
https://doaj.org/article/64c2683511e049649c96119d191110c7
Autor:
Lloyd A. C. Chapman, Maite Aubry, Noémie Maset, Timothy W. Russell, Edward S. Knock, John A. Lees, Henri-Pierre Mallet, Van-Mai Cao-Lormeau, Adam J. Kucharski
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Estimating the impact of vaccination and non-pharmaceutical interventions on COVID-19 incidence is complicated by several factors, including successive emergence of SARS-CoV-2 variants of concern and changing population immunity from vaccina
Externí odkaz:
https://doaj.org/article/768b64a61cdd41d29d0efc18fd5def02
Autor:
Tonia Zangari, M. Ammar Zafar, John A. Lees, Annie R. Abruzzo, Gavyn Chern Wei Bee, Jeffrey N. Weiser
Publikováno v:
npj Vaccines, Vol 6, Iss 1, Pp 1-9 (2021)
Abstract Vaccines targeting Streptococcus pneumoniae (Spn) are limited by dependence on capsular polysaccharide and its serotype diversity. More broadly-based approaches using common protein antigens have not resulted in a licensed vaccine. Herein, w
Externí odkaz:
https://doaj.org/article/181763b877054cdb834eea67101b2637
Autor:
Oliver J. Watson, Mervat Alhaffar, Zaki Mehchy, Charles Whittaker, Zack Akil, Nicholas F. Brazeau, Gina Cuomo-Dannenburg, Arran Hamlet, Hayley A. Thompson, Marc Baguelin, Richard G. FitzJohn, Edward Knock, John A. Lees, Lilith K. Whittles, Thomas Mellan, Peter Winskill, Imperial College COVID-19 Response Team, Natasha Howard, Hannah Clapham, Francesco Checchi, Neil Ferguson, Azra Ghani, Emma Beals, Patrick Walker
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Reported COVID-19 mortality rates have been relatively low in Syria, but there has been concern about overwhelmed health systems. Here, the authors use community mortality indicators and estimate that
Externí odkaz:
https://doaj.org/article/d38584387183491087e55021781efb7e
Autor:
Anna K. Pöntinen, Janetta Top, Sergio Arredondo-Alonso, Gerry Tonkin-Hill, Ana R. Freitas, Carla Novais, Rebecca A. Gladstone, Maiju Pesonen, Rodrigo Meneses, Henri Pesonen, John A. Lees, Dorota Jamrozy, Stephen D. Bentley, Val F. Lanza, Carmen Torres, Luisa Peixe, Teresa M. Coque, Julian Parkhill, Anita C. Schürch, Rob J. L. Willems, Jukka Corander
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Enterococcus faecalis is a commensal microorganism of animals, insects and humans, but also a nosocomial pathogen. Here, the authors analyse genomic sequences from E. faecalis isolates from animals and humans, and find that the last common ancestors
Externí odkaz:
https://doaj.org/article/7681bee6cee34c6d8a4c06f210f980be
Autor:
Pierre Nouvellet, Sangeeta Bhatia, Anne Cori, Kylie E. C. Ainslie, Marc Baguelin, Samir Bhatt, Adhiratha Boonyasiri, Nicholas F. Brazeau, Lorenzo Cattarino, Laura V. Cooper, Helen Coupland, Zulma M. Cucunuba, Gina Cuomo-Dannenburg, Amy Dighe, Bimandra A. Djaafara, Ilaria Dorigatti, Oliver D. Eales, Sabine L. van Elsland, Fabricia F. Nascimento, Richard G. FitzJohn, Katy A. M. Gaythorpe, Lily Geidelberg, William D. Green, Arran Hamlet, Katharina Hauck, Wes Hinsley, Natsuko Imai, Benjamin Jeffrey, Edward Knock, Daniel J. Laydon, John A. Lees, Tara Mangal, Thomas A. Mellan, Gemma Nedjati-Gilani, Kris V. Parag, Margarita Pons-Salort, Manon Ragonnet-Cronin, Steven Riley, H. Juliette T. Unwin, Robert Verity, Michaela A. C. Vollmer, Erik Volz, Patrick G. T. Walker, Caroline E. Walters, Haowei Wang, Oliver J. Watson, Charles Whittaker, Lilith K. Whittles, Xiaoyue Xi, Neil M. Ferguson, Christl A. Donnelly
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Social distancing policies aiming to reduce COVID-19 transmission have been reflected in reductions in human mobility. Here, the authors show that reduced mobility is correlated with decreased transmission, but that this relationship weakened over ti
Externí odkaz:
https://doaj.org/article/b3908b3fb9ed4fc382c17de133afb0ca
Database of epidemic trends and control measures during the first wave of COVID-19 in mainland China
Autor:
Han Fu, Haowei Wang, Xiaoyue Xi, Adhiratha Boonyasiri, Yuanrong Wang, Wes Hinsley, Keith J. Fraser, Ruth McCabe, Daniela Olivera Mesa, Janetta Skarp, Alice Ledda, Tamsin Dewé, Amy Dighe, Peter Winskill, Sabine L. van Elsland, Kylie E.C. Ainslie, Marc Baguelin, Samir Bhatt, Olivia Boyd, Nicholas F. Brazeau, Lorenzo Cattarino, Giovanni Charles, Helen Coupland, Zulma M. Cucunuba, Gina Cuomo-Dannenburg, Christl A. Donnelly, Ilaria Dorigatti, Oliver D. Eales, Richard G. FitzJohn, Seth Flaxman, Katy A.M. Gaythorpe, Azra C. Ghani, William D. Green, Arran Hamlet, Katharina Hauck, David J. Haw, Benjamin Jeffrey, Daniel J. Laydon, John A. Lees, Thomas Mellan, Swapnil Mishra, Gemma Nedjati-Gilani, Pierre Nouvellet, Lucy Okell, Kris V. Parag, Manon Ragonnet-Cronin, Steven Riley, Nora Schmit, Hayley A. Thompson, H.Juliette T. Unwin, Robert Verity, Michaela A.C. Vollmer, Erik Volz, Patrick G.T. Walker, Caroline E. Walters, Oliver J. Watson, Charles Whittaker, Lilith K. Whittles, Natsuko Imai, Sangeeta Bhatia, Neil M. Ferguson
Publikováno v:
International Journal of Infectious Diseases, Vol 102, Iss , Pp 463-471 (2021)
Objectives: In this data collation study, we aimed to provide a comprehensive database describing the epidemic trends and responses during the first wave of coronavirus disease 2019 (COVID-19) throughout the main provinces in China. Methods: From mid
Externí odkaz:
https://doaj.org/article/0cffb311fe9c4c02a89e451c3b8e2bb8
Autor:
Gerry Tonkin-Hill, Neil MacAlasdair, Christopher Ruis, Aaron Weimann, Gal Horesh, John A. Lees, Rebecca A. Gladstone, Stephanie Lo, Christopher Beaudoin, R. Andres Floto, Simon D.W. Frost, Jukka Corander, Stephen D. Bentley, Julian Parkhill
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-21 (2020)
Abstract Population-level comparisons of prokaryotic genomes must take into account the substantial differences in gene content resulting from horizontal gene transfer, gene duplication and gene loss. However, the automated annotation of prokaryotic
Externí odkaz:
https://doaj.org/article/2f993c35887e4f39985ba6d4d8cee246
Autor:
Richard G. FitzJohn, Edward S. Knock, Lilith K. Whittles, Pablo N. Perez-Guzman, Sangeeta Bhatia, Fernando Guntoro, Oliver J. Watson, Charles Whittaker, Neil M. Ferguson, Anne Cori, Marc Baguelin, John A. Lees
Publikováno v:
Wellcome Open Research, Vol 5 (2021)
State space models, including compartmental models, are used to model physical, biological and social phenomena in a broad range of scientific fields. A common way of representing the underlying processes in these models is as a system of stochastic
Externí odkaz:
https://doaj.org/article/a03cbc2f0fe0448ebd87a14a0aaaa7d3
Autor:
John A. Lees, Bart Ferwerda, Philip H. C. Kremer, Nicole E. Wheeler, Mercedes Valls Serón, Nicholas J. Croucher, Rebecca A. Gladstone, Hester J. Bootsma, Nynke Y. Rots, Alienke J. Wijmega-Monsuur, Elisabeth A. M. Sanders, Krzysztof Trzciński, Anne L. Wyllie, Aeilko H. Zwinderman, Leonard H. van den Berg, Wouter van Rheenen, Jan H. Veldink, Zitta B. Harboe, Lene F. Lundbo, Lisette C. P. G. M. de Groot, Natasja M. van Schoor, Nathalie van der Velde, Lars H. Ängquist, Thorkild I. A. Sørensen, Ellen A. Nohr, Alexander J. Mentzer, Tara C. Mills, Julian C. Knight, Mignon du Plessis, Susan Nzenze, Jeffrey N. Weiser, Julian Parkhill, Shabir Madhi, Thomas Benfield, Anne von Gottberg, Arie van der Ende, Matthijs C. Brouwer, Jeffrey C. Barrett, Stephen D. Bentley, Diederik van de Beek
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Streptococcus pneumoniae is a causative agent of meningitis and bacteremia. In a combined pathogen and host GWAS, Lees et al. find that host genetic variation is associated with both susceptibility and severity of pneumococcal meningitis, and specifi
Externí odkaz:
https://doaj.org/article/676c4fca20864aaa9d086a45a85f61c3