Zobrazeno 1 - 10
of 22
pro vyhledávání: '"John A. Kennard"'
Autor:
John A. Kennard, Diana S. Woodruff-Pak
Publikováno v:
Frontiers in Aging Neuroscience, Vol 3 (2011)
Knowledge of age sensitivity, the capacity of a behavioral test to reliably detect age-related changes, has utility in the design of experiments to elucidate processes of normal aging. We review the application of these tests in studies of normal agi
Externí odkaz:
https://doaj.org/article/ec6a9f11799c4db485cda95f234157d0
Autor:
Angeline J. Eugene, Jing-Qiong Kang, Lisa M. Moore, Eric Sean Kessler, Daniel A. Scharf, Timothy A. Warner, David C. Consoli, Deborah J. Mi, Shilpy Dixit, Fiona E. Harrison, John A. Kennard, Corey W. Bown
Publikováno v:
Neurobiology of Aging. 71:241-254
Ascorbate (vitamin C) is critical as a first line of defense antioxidant within the brain, and specifically within the synapse. Ascorbate is released by astrocytes during glutamate clearance and disruption of this exchange mechanism may be critical i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ee756d318b613191ee5a564f4458363
https://doi.org/10.1016/j.neurobiolaging.2018.08.002
https://doi.org/10.1016/j.neurobiolaging.2018.08.002
Publikováno v:
Epilepsy Research. 110:20-25
Seizures are a known co-occurring symptom of Alzheimer's disease, and they can accelerate cognitive and neuropathological dysfunction. Sub-optimal vitamin C (ascorbic acid) deficiency, that is low levels that do not lead the sufferer to present with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85091232cb1021114cbc19fa46ba199f
https://doi.org/10.1016/j.eplepsyres.2014.11.017
https://doi.org/10.1016/j.eplepsyres.2014.11.017
Autor:
John A. Kennard, Fiona E. Harrison
Publikováno v:
Behavioural Brain Research. 264:34-42
The present study investigated the effects of a single intravenous (i.v.) dose of Vitamin C (ascorbate, ASC) on spatial memory in APP/PSEN1 mice, an Alzheimer's disease model. First, we confirmed the uptake time course in ASC-depleted gulo (−/−)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d20269574eaa40e934cc9606ad17c73e
https://doi.org/10.1016/j.bbr.2014.01.044
https://doi.org/10.1016/j.bbr.2014.01.044
Autor:
John A. Kennard, Diana S. Woodruff-Pak
Publikováno v:
Physiology & Behavior. 106:423-427
In this study we compared two types of forced exercise—a low impact paradigm to minimize stress, which included speeds up to 10 m/min and a stressful high impact paradigm, with speeds up to 21 m/min. 150 male C57BL/6J mice were randomly assigned to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::128e52cc3f03bce25dd7c945da5728b3
https://doi.org/10.1016/j.physbeh.2012.02.023
https://doi.org/10.1016/j.physbeh.2012.02.023
Publikováno v:
Behavioural Brain Research. 225:290-296
The context preexposure facilitation effect (CPFE) is an elaboration of contextual fear conditioning and refers to enhanced contextual conditioning resulting from preexposure to the context prior to a separate, brief context-shock episode. A version
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1282ac969c16d21bc6ca6cbab2e89f61
https://doi.org/10.1016/j.bbr.2011.07.044
https://doi.org/10.1016/j.bbr.2011.07.044
Autor:
Garnik G. Akopian, Ka Hung Lee, Alexis Agelan, Kim Phuong Thi Nguyen, Diana S. Woodruff-Pak, Michael R. Foy, Jordan Zach, John A. Kennard, Richard F. Thompson, David M. Comalli
Publikováno v:
Proceedings of the National Academy of Sciences. 107:1624-1629
Cognitive functions show many alternative outcomes and great individual variation during normal aging. We examined learning over the adult life span in CBA mice, along with morphological and electrophysiological substrates. Our aim was to compare cer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9e665f72573107f27faa88c39770456
https://doi.org/10.1073/pnas.0914207107
https://doi.org/10.1073/pnas.0914207107
Autor:
Jennifer M. Walker, Eric Sean Kessler, Grace Youngeun Kim, Fiona E. Harrison, Shilpy Dixit, John A. Kennard, Alexandra Bernardo
Subclinical vitamin C deficiency is widespread in many populations, but its role in both Alzheimer's disease and normal aging is understudied. In the present study, we decreased brain vitamin C in the APPSWE/PSEN1deltaE9 mouse model of Alzheimer's di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92d7c554dd54dfc3b9b95db84aca3e4b
https://europepmc.org/articles/PMC4476071/
https://europepmc.org/articles/PMC4476071/
Publikováno v:
The Corsini Encyclopedia of Psychology. :1-3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad2845719eb6626e059804476dac53f9
https://doi.org/10.1002/9780470479216.corpsy0873
https://doi.org/10.1002/9780470479216.corpsy0873