Zobrazeno 1 - 10
of 1 684
pro vyhledávání: '"John A. Gray"'
Autor:
Oluwarotimi O. Folorunso, Stephanie E. Brown, Jugajyoti Baruah, Theresa L. Harvey, Shekib A. Jami, Inna Radzishevsky, Herman Wolosker, James M. McNally, John A. Gray, Anju Vasudevan, Darrick T. Balu
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract The proper development and function of telencephalic GABAergic interneurons is critical for maintaining the excitation and inhibition (E/I) balance in cortical circuits. Glutamate contributes to cortical interneuron (CIN) development via N-m
Externí odkaz:
https://doaj.org/article/c1a3de421db14b62abea4c8f005bf011
Autor:
Inmaculada M. González-González, John A. Gray, Joana Ferreira, María Jose Conde-Dusman, Delphine Bouchet, Isabel Perez-Otaño, Laurent Groc
Publikováno v:
Cell Reports, Vol 42, Iss 5, Pp 112477- (2023)
Summary: Signaling via N-methyl-d-aspartate receptors (NMDARs) is critical for the maturation of glutamatergic synapses, partly through a developmental switch from immature synapses expressing primarily GluN2B- and GluN3A-containing subtypes to GluN2
Externí odkaz:
https://doaj.org/article/bf9666f4a96d4c7eb23dd56fc77bb8ac
Autor:
Deborah K. Park, Samuel Petshow, Margarita Anisimova, Eden V. Barragan, John A. Gray, Ivar S. Stein, Karen Zito
Publikováno v:
Neurobiology of Disease, Vol 170, Iss , Pp 105772- (2022)
Schizophrenia is a psychiatric disorder that affects over 20 million people globally. Notably, schizophrenia is associated with decreased density of dendritic spines and decreased levels of d-serine, a co-agonist required for opening of the N-methyl-
Externí odkaz:
https://doaj.org/article/2f0119526f84455fa51830e1cb293a2b
Autor:
Calvin Ly, Alexandra C. Greb, Lindsay P. Cameron, Jonathan M. Wong, Eden V. Barragan, Paige C. Wilson, Kyle F. Burbach, Sina Soltanzadeh Zarandi, Alexander Sood, Michael R. Paddy, Whitney C. Duim, Megan Y. Dennis, A. Kimberley McAllister, Kassandra M. Ori-McKenney, John A. Gray, David E. Olson
Publikováno v:
Cell Reports, Vol 23, Iss 11, Pp 3170-3182 (2018)
Summary: Atrophy of neurons in the prefrontal cortex (PFC) plays a key role in the pathophysiology of depression and related disorders. The ability to promote both structural and functional plasticity in the PFC has been hypothesized to underlie the
Externí odkaz:
https://doaj.org/article/fab3a30f83314b318faa3be216735c44
Autor:
Andrew M. Chiu, Jiejie Wang, Michael P. Fiske, Pavla Hubalkova, Levi Barse, John A. Gray, Antonio Sanz-Clemente
Publikováno v:
Cell Reports, Vol 28, Iss 2, Pp 332-341.e5 (2019)
Summary: In mature neurons, postsynaptic N-methyl-D-aspartate receptors (NMDARs) are segregated into two populations, synaptic and extrasynaptic, which differ in localization, function, and associated intracellular cascades. These two pools are conne
Externí odkaz:
https://doaj.org/article/73f76fc17f9a441ead351253b1e1f347
Publikováno v:
Cell Reports, Vol 3, Iss 3, Pp 607-614 (2013)
Synaptic activity triggers a profound reorganization of the molecular composition of excitatory synapses. For example, NMDA receptors are removed from synapses in an activity- and calcium-dependent manner, via casein kinase 2 (CK2) phosphorylation of
Externí odkaz:
https://doaj.org/article/1d36bef6b1e9466fbad22174eb7a5252
Autor:
Bo-Shiun Chen, John A. Gray, Antonio Sanz-Clemente, Zhe Wei, Eleanor V. Thomas, Roger A. Nicoll, Katherine W. Roche
Publikováno v:
Cell Reports, Vol 2, Iss 5, Pp 1120-1128 (2012)
Membrane-associated guanylate kinases (MAGUKs) are the major family of scaffolding proteins at the postsynaptic density. The PSD-MAGUK subfamily, which includes PSD-95, PSD-93, SAP97, and SAP102, is well accepted to be primarily involved in the synap
Externí odkaz:
https://doaj.org/article/fb714d238a724fab8a66524b370c6ebe
Publikováno v:
F1000Research, Vol 5 (2016)
Provocative emerging evidence suggests that the N-methyl-D-aspartate (NMDA) receptor can signal in the absence of ion flux through the receptor. This non-ionotropic signaling is thought to be due to agonist-induced conformational changes in the recep
Externí odkaz:
https://doaj.org/article/784f52a7d5634a8e8391e989161e34fb
Autor:
Spencer D. Fallek, Vikram S. Sandhu, Ryan A. McGill, John M. Gray, Holly N. Tinkey, Craig R. Clark, Kenton R. Brown
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-9 (2024)
Abstract The trapped-ion quantum charge-coupled device (QCCD) architecture is a leading candidate for advanced quantum information processing. In current QCCD implementations, imperfect ion transport and anomalous heating can excite ion motion during
Externí odkaz:
https://doaj.org/article/53d0d882d9bb4b5a88bbe71815b6ea87
Autor:
Maxemiliano V. Vargas, Lee E. Dunlap, Chunyang Dong, Samuel J. Carter, Robert J. Tombari, Shekib A. Jami, Lindsay P. Cameron, Seona D. Patel, Joseph J. Hennessey, Hannah N. Saeger, John D. McCorvy, John A. Gray, Lin Tian, David E. Olson
Publikováno v:
Science. 379:700-706
Decreased dendritic spine density in the cortex is a hallmark of several neuropsychiatric diseases, and the ability to promote cortical neuron growth has been hypothesized to underlie the rapid and sustained therapeutic effects of psychedelics. Activ