Zobrazeno 1 - 10
of 176
pro vyhledávání: '"John A. Gagnon"'
Autor:
Benjamin D Wheeler, John D Gagnon, Wandi S Zhu, Priscila Muñoz-Sandoval, Simon K Wong, Dimitre S Simeonov, Zhongmei Li, Rachel DeBarge, Matthew H Spitzer, Alexander Marson, K Mark Ansel
Publikováno v:
eLife, Vol 12 (2023)
Proper activation of cytotoxic T cells via the T cell receptor and the costimulatory receptor CD28 is essential for adaptive immunity against viruses, intracellular bacteria, and cancers. Through biochemical analysis of RNA:protein interactions, we u
Externí odkaz:
https://doaj.org/article/6b38f61a3ba74929aacd66d5b01fa903
Autor:
Kristina Johansson, John D. Gagnon, Simon K. Zhou, Marlys S. Fassett, Andrew W. Schroeder, Robin Kageyama, Rodriel A. Bautista, Hewlett Pham, Prescott G. Woodruff, K. Mark Ansel
Publikováno v:
Cell Reports, Vol 42, Iss 10, Pp 113298- (2023)
Summary: The miR-15/16 family targets a large network of genes in T cells to restrict their cell cycle, memory formation, and survival. Upon T cell activation, miR-15/16 are downregulated, allowing rapid expansion of differentiated effector T cells t
Externí odkaz:
https://doaj.org/article/769f6088e5054e208c6c0b1f112161c5
Autor:
Marianne Dölz, Marko Hasiuk, John D. Gagnon, Mara Kornete, Romina Marone, Glenn Bantug, Robin Kageyama, Christoph Hess, K. Mark Ansel, Denis Seyres, Julien Roux, Lukas T. Jeker
Publikováno v:
iScience, Vol 25, Iss 11, Pp 105372- (2022)
Summary: CD28 provides the prototypical costimulatory signal required for productive T-cell activation. Known molecular consequences of CD28 costimulation are mostly based on studies of protein signaling molecules. The microRNA cluster miR-17∼92 is
Externí odkaz:
https://doaj.org/article/67c963c2510444389bd28b000ba0d552
Autor:
John D. Gagnon, Robin Kageyama, Hesham M. Shehata, Marlys S. Fassett, Darryl J. Mar, Eric J. Wigton, Kristina Johansson, Adam J. Litterman, Pamela Odorizzi, Dimitre Simeonov, Brian J. Laidlaw, Marisella Panduro, Sana Patel, Lukas T. Jeker, Margaret E. Feeney, Michael T. McManus, Alexander Marson, Mehrdad Matloubian, Shomyseh Sanjabi, K. Mark Ansel
Publikováno v:
Cell Reports, Vol 28, Iss 8, Pp 2169-2181.e4 (2019)
Summary: Coordinate control of T cell proliferation, survival, and differentiation are essential for host protection from pathogens and cancer. Long-lived memory cells, whose precursors are formed during the initial immunological insult, provide prot
Externí odkaz:
https://doaj.org/article/a486a73611da46498ae2a935b948d107
Autor:
Jun Feng, Drake LeFace, Aaron Cooper, Michelle L.T. Nguyen, Suchismita Mohanty, Angela C. Boroughs, Jason F. Hall, Adam J. Litterman, Jenessa B. Smith, Jeff Granja, Dina Polyak, John D. Gagnon, Jaspar Williams, Kanika Chawla, Susie Jun, Stephen Santoro, Tarjei S. Mikkelsen, Grace X.Y. Zheng, Natalie Bezman, David DeTomaso
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
BackgroundIn solid tumors, CAR T cell efficacy is limited by off-tumor toxicity and suppression by the tumor microenvironment (TME). AB-X is an integrated circuit T cell (ICT cell) intended for the treatment of ovarian cancer. AB-X includes a transge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c89edc3053830fbe14b9563e30d11b6
https://doaj.org/article/3de68468bbeb414eb0074915461c96fd
https://doaj.org/article/3de68468bbeb414eb0074915461c96fd
Autor:
Bernard Khor, John D Gagnon, Gautam Goel, Marly I Roche, Kara L Conway, Khoa Tran, Leslie N Aldrich, Thomas B Sundberg, Alison M Paterson, Scott Mordecai, David Dombkowski, Melanie Schirmer, Pauline H Tan, Atul K Bhan, Rahul Roychoudhuri, Nicholas P Restifo, John J O'Shea, Benjamin D Medoff, Alykhan F Shamji, Stuart L Schreiber, Arlene H Sharpe, Stanley Y Shaw, Ramnik J Xavier
Publikováno v:
eLife, Vol 4 (2015)
The balance between Th17 and T regulatory (Treg) cells critically modulates immune homeostasis, with an inadequate Treg response contributing to inflammatory disease. Using an unbiased chemical biology approach, we identified a novel role for the dua
Externí odkaz:
https://doaj.org/article/8d529be262854d4f87b10c044565271a
Autor:
Sana Patel, Michael T. McManus, Brian J. Laidlaw, Mehrdad Matloubian, Dimitre R. Simeonov, Marlys S. Fassett, Pamela M. Odorizzi, Robin Kageyama, Marisella Panduro, K. Mark Ansel, John D. Gagnon, Kristina Johansson, Lukas T. Jeker, Eric J. Wigton, Alexander Marson, Darryl J. Mar, Margaret E. Feeney, Adam J. Litterman, Shomyseh Sanjabi, Hesham M. Shehata
Publikováno v:
Cell Reports, Vol 28, Iss 8, Pp 2169-2181.e4 (2019)
Cell reports
Cell reports, vol 28, iss 8
Cell reports
Cell reports, vol 28, iss 8
SUMMARY Coordinate control of T cell proliferation, survival, and differentiation are essential for host protection from pathogens and cancer. Long-lived memory cells, whose precursors are formed during the initial immunological insult, provide prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47ff0a7e978c7eba67bdb46857e1545b
http://www.sciencedirect.com/science/article/pii/S2211124719309684
http://www.sciencedirect.com/science/article/pii/S2211124719309684
Autor:
K. Mark Ansel, Olivier Le Tonqueze, Wenxue Zhao, David J. Erle, John D. Gagnon, Hani Goodarzi, Adam J. Litterman, Robin Kageyama
Publikováno v:
Genome research, vol 29, iss 6
Compared to coding sequences, untranslated regions of the transcriptome are not well conserved, and functional annotation of these sequences is challenging. Global relationships between nucleotide composition of 3′ UTR sequences and their sequence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e16b34abea3802038675a28eb4970fe
https://doi.org/10.1101/gr.242552.118
https://doi.org/10.1101/gr.242552.118
Autor:
Christoph Hess, Lukas T. Jeker, Denis Seyres, Mara Kornete, Marianne Dölz, Julien Roux, Robin Kageyama, Romina Marone, Glenn R. Bantug, K. Mark Ansel, John D. Gagnon
SummaryT cell activation is paramount for productive adaptive immune responses. CD28 is a key clinically targeted immunoregulatory receptor because it provides the prototypical costimulatory signal required for T cell activation. Therefore, a precise
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1fd1f679ba8eaf196a6104f9f5959e57
https://doi.org/10.1101/2020.10.13.336537
https://doi.org/10.1101/2020.10.13.336537
