Zobrazeno 1 - 10
of 165
pro vyhledávání: '"John A. G. Briggs"'
Autor:
Katherine U. Gaynor, Marina Vaysburd, Maximilian A. J. Harman, Anna Albecka, Phillip Jeffrey, Paul Beswick, Guido Papa, Liuhong Chen, Donna Mallery, Brian McGuinness, Katerine Van Rietschoten, Steven Stanway, Paul Brear, Aleksei Lulla, Katarzyna Ciazynska, Veronica T. Chang, Jo Sharp, Megan Neary, Helen Box, Jo Herriott, Edyta Kijak, Lee Tatham, Eleanor G. Bentley, Parul Sharma, Adam Kirby, Ximeng Han, James P. Stewart, Andrew Owen, John A. G. Briggs, Marko Hyvönen, Michael J. Skynner, Leo C. James
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract COVID-19 has stimulated the rapid development of new antibody and small molecule therapeutics to inhibit SARS-CoV-2 infection. Here we describe a third antiviral modality that combines the drug-like advantages of both. Bicycles are entropica
Externí odkaz:
https://doaj.org/article/83eee9acaa674188b99a7694be9c0c15
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Simulations reveal concerted interactions between the SARS-CoV-2 spike trimers and ACE2 receptors that result in cooperative spike binding and shedding, and further suggest that variant efficacy is promoted by increased RBD opening or S1/S2 cleavage
Externí odkaz:
https://doaj.org/article/b7971dbf743c4c2a9d686fef92340311
Autor:
Shirley Tremel, Yohei Ohashi, Dustin R. Morado, Jessie Bertram, Olga Perisic, Laura T. L. Brandt, Marie-Kristin von Wrisberg, Zhuo A. Chen, Sarah L. Maslen, Oleksiy Kovtun, Mark Skehel, Juri Rappsilber, Kathrin Lang, Sean Munro, John A. G. Briggs, Roger L. Williams
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
The phosphatidylinositol-3-phosphate (PI3P) is generated by the lipid kinase VPS34, in the context of VPS34 complex I on autophagosomes or complex II on endosomes. Biochemical and structural analyses provide insights into the mechanism of both VPS34
Externí odkaz:
https://doaj.org/article/d0b77c3d6f3f4cfcbbaf6326c8d008f3
Autor:
Robert A Dick, Chaoyi Xu, Dustin R Morado, Vladyslav Kravchuk, Clifton L Ricana, Terri D Lyddon, Arianna M Broad, J Ryan Feathers, Marc C Johnson, Volker M Vogt, Juan R Perilla, John A G Briggs, Florian K M Schur
Publikováno v:
PLoS Pathogens, Vol 16, Iss 1, p e1008277 (2020)
Retrovirus assembly is driven by the multidomain structural protein Gag. Interactions between the capsid domains (CA) of Gag result in Gag multimerization, leading to an immature virus particle that is formed by a protein lattice based on dimeric, tr
Externí odkaz:
https://doaj.org/article/c3daa523b8f640e092a5ea59c68b3690
Autor:
Junjie Xu, Simon Erlendsson, Manvendra Singh, Matthew Regier, Iosune Ibiricu, Gregory S. Day, Amanda L. Piquet, Stacey L. Clardy, Cedric Feschotte, John A. G. Briggs, Jason D. Shepherd
Publikováno v:
bioRxiv
Theparaneoplastic Ma antigen(PNMA) genes are associated with cancer-induced paraneoplastic syndromes that present with neurological symptoms and autoantibody production. How PNMA proteins trigger a severe autoimmune disease is unclear.PNMAgenes are p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::493fe0a65a242c127cd89b91c1fe570a
https://europepmc.org/articles/PMC9934673/
https://europepmc.org/articles/PMC9934673/
Autor:
Jasenko Zivanov, Joaquín Otón, Zunlong Ke, Andriko von Kügelgen, Euan Pyle, Kun Qu, Dustin Morado, Daniel Castaño-Díez, Giulia Zanetti, Tanmay A. M. Bharat, John A. G. Briggs, Sjors H. W. Scheres
We present a new approach for macromolecular structure determination from multiple particles in electron cryo-tomography (cryo-ET) data sets. Whereas existing subtomogram averaging approaches are based on 3D data models, we propose to optimise a regu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a235557680d0b8891dc9b591eaaeef91
The HIV-1 capsid houses the viral genome and interacts extensively with host cell proteins throughout the viral life cycle. It is composed of capsid protein (CA), which assembles into a conical fullerene lattice composed of roughly 200 CA hexamers an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ab9655a8aec0d66beecd359f8fbeb8f
https://doi.org/10.1101/2022.12.02.518872
https://doi.org/10.1101/2022.12.02.518872
Publikováno v:
FEBS lettersReferences.
COPI-coated vesicles mediate transport between Golgi stacks and retrograde transport from the Golgi to the endoplasmic reticulum. The COPI coat exists as a stable heptameric complex in the cytosol termed coatomer and is recruited en bloc to the membr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e2eaebf7bc470ed19dedbbdb370a208
https://pubmed.ncbi.nlm.nih.gov/36513395
https://pubmed.ncbi.nlm.nih.gov/36513395
Autor:
George Carnell, James A. Nathan, Jessica Gronlund, Mina Paloniemi, Jakub Luptak, Paul Tonks, Sumita Pai, Soraya Ebrahimi, David A. Wells, Sara Lear, Leo C. James, Lourdes Ceron-Gutierrez, Rainer Döffinger, Helen Baxendale, Jonathan L. Heeney, John A. G. Briggs, Ashleigh Sayer, Angalee Nadesalingham, Guinevere L. Grice, Xiaoli Ziong
Publikováno v:
The Journal of Critical Care Medicine
The Journal of Critical Care Medicine, Vol 7, Iss 3, Pp 199-210 (2021)
The Journal of Critical Care Medicine, Vol 7, Iss 3, Pp 199-210 (2021)
Introduction In early 2020, at first surge of the coronavirus disease 2019 (COVID-19) pandemic, many health care workers (HCW) were re-deployed to critical care environments to support intensive care teams looking after patients with severe COVID-19.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2d739dfeed0b0cac306b431a75c6246
http://europepmc.org/articles/PMC8519390
http://europepmc.org/articles/PMC8519390
Autor:
Svetlana O Dodonova, Patrick Aderhold, Juergen Kopp, Iva Ganeva, Simone Röhling, Wim J H Hagen, Irmgard Sinning, Felix Wieland, John A G Briggs
Publikováno v:
eLife, Vol 6 (2017)
COPI coated vesicles mediate trafficking within the Golgi apparatus and between the Golgi and the endoplasmic reticulum. Assembly of a COPI coated vesicle is initiated by the small GTPase Arf1 that recruits the coatomer complex to the membrane, trigg
Externí odkaz:
https://doaj.org/article/300fbb86222a4c5989cb1a9db6e217d6