Zobrazeno 1 - 10
of 66
pro vyhledávání: '"John A. Flygare"'
Autor:
Wendy Cao, Johnathan C. Maza, Natalia Chernyak, John A. Flygare, Shane W. Krska, F. Dean Toste, Matthew B. Francis
Publikováno v:
Bioconjugate Chemistry. 34:510-517
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d5746bbfe8c171172c1eed58f7e5693
https://doi.org/10.1021/acs.bioconjchem.2c00576
https://doi.org/10.1021/acs.bioconjchem.2c00576
Autor:
Jagath R. Junutula, John A. Flygare, Andrew G. Polson, Paul Polakis, Susan Spencer, Katherine K. Kozak, Janet Gunzner-Toste, Jinhua Chen, Fan Fang, Philip W. Howard, Stephen J. Gregson, Luke Masterson, Donglu Zhang, Amrita V. Kamath, Douglas D. Leipold, Keyang Xu, Carl Ng, Luna Liu, Jintang He, Sharon Yee, Jeffrey Lau, Mary Ann T. Go, Geoffrey Del Rosario, Fiona Zhong, Willy Solis, Kirsten Achilles Poon, Jack Sadowsky, Rachana Ohri, Shang-Fan Yu, Melissa Schutten, Thomas H. Pillow
Supplementary Figures S1-S5, Supplementary Materials and Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14bd04853a3b7478b1a76289e951f293
https://doi.org/10.1158/1535-7163.22503312.v1
https://doi.org/10.1158/1535-7163.22503312.v1
Autor:
Paul Nimmer, Erwin R. Boghaert, Robin R. Frey, Phuong N Le, Andrew J. Souers, Peter Kovar, Wenqing Gao, Deepak Sampath, Dolores Diaz, Haichao Zhang, T. Matthew Hansen, Michael J. Mitten, Stephen K. Tahir, Russell A. Judge, Edna F. Choo, Yu Xiao, Shashank Shekhar, Xiaohong Song, George Doherty, Zhi-Fu Tao, Andrew S. Judd, Wayne J. Fairbrother, Michael D. Wendt, Steven W. Elmore, Kunzer Aaron R, Le Wang, Xilu Wang, Darren C. Phillips, Morey L. Smith, John A. Flygare, John Xue, Joel D. Leverson, Milan Bruncko, Chang H. Park, Nathaniel D. Catron
Publikováno v:
ACS Medicinal Chemistry Letters
Herein we describe the discovery of A-1331852, a first-in-class orally active BCL-XL inhibitor that selectively and potently induces apoptosis in BCL-XL-dependent tumor cells. This molecule was generated by re-engineering our previously reported BCL-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85af09593f6d81ea66757099b5fec23d
http://europepmc.org/articles/PMC7549103
http://europepmc.org/articles/PMC7549103
Autor:
Ryan L. Gonciarz, Honglin Jiang, Cedric L. Hugelshofer, Oscar Ekpenyong, Ian Knemeyer, John A. Flygare, Eric A. Collisson, Adam R. Renslo
Publikováno v:
SSRN Electronic Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::efdc0ef96d2b30b5c1a77a27046f83a1
https://doi.org/10.2139/ssrn.4279906
https://doi.org/10.2139/ssrn.4279906
Autor:
Gilberto E. Fernandez, Paroma Chakravarty, David H. Russell, Harvey Wong, Wayne J. Fairbrother, Danny Shih, Hank La, Ajit S. Narang, Ronald Steigerwalt, Minli Xie, Priscilla Mantik, Geoffrey Ganem, John A. Flygare, Uday Devanaboyina
Publikováno v:
Journal of Pharmaceutical Sciences. 108:1934-1943
Solubilization of new chemical entities for toxicity assessment must use excipients that do not negatively impact drug pharmacokinetics and toxicology. In this study, we investigated the tolerability of a model freebase compound, GDC-0152, solubilize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d36676e006855d921476d5a2533c0db0
https://doi.org/10.1016/j.xphs.2019.01.004
https://doi.org/10.1016/j.xphs.2019.01.004
Autor:
Katherine R. Kozak, Siao Ping Tsai, Doug Leipold, Luke Masterson, Hui Yao, Stefan Steinbacher, Jim Nonomiya, Keyang Xu, Helga Raab, Vishal Verma, Binqing Wei, Jeff Lau, Tao Wang, Janet Gunzner-Toste, Shang-Fan Yu, John A. Flygare, Thomas H. Pillow, Leanna Staben, John S. Wai, Zijin Xu, Brian Safina, Gail Dianne Phillips, Philip Howard, Jing Wang, Dian Su, Josefa Chuh, Jinhua Chen, Guiling Zhao, Guangmin Li, Rachana Ohri, Yichin Liu, Amrita V. Kamath, Charles Eigenbrot
Publikováno v:
Journal of Medicinal Chemistry. 61:989-1000
Antibody-drug conjugates (ADCs) have become an important therapeutic modality for oncology, with three approved by the FDA and over 60 others in clinical trials. Despite the progress, improvements in ADC therapeutic index are desired. Peptide-based A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ec0f3685ed5ba96d277235ba33db5f5
https://doi.org/10.1021/acs.jmedchem.7b01430
https://doi.org/10.1021/acs.jmedchem.7b01430
Autor:
Binqing Wei, Janet Gunzner-Toste, Guangmin Li, Helga Raab, Susan D. Spencer, Gail Lewis Phillips, Shang-Fan Yu, Katherine R. Kozak, Rachana Ohri, Jeffrey Lau, Philip Howard, Andrew Polson, Brian Safina, Luke Masterson, John A. Flygare, Thomas H. Pillow, Martine Darwish, Stephen J. Gregson, Gyoung-Dong Kang, Josefa dela Cruz-Chuh
Publikováno v:
Journal of Medicinal Chemistry. 60:9490-9507
Three rationally designed pyrrolobenzodiazepine (PBD) drug-linkers have been synthesized via intermediate 19 for use in antibody–drug conjugates (ADCs). They lack a cleavable trigger in the linker and consist of a maleimide for cysteine antibody co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a180d2e49398f22d60da17ee0112defd
https://doi.org/10.1021/acs.jmedchem.7b00736
https://doi.org/10.1021/acs.jmedchem.7b00736
Publikováno v:
The Febs Journal
The reversible post‐translational modification of proteins by ubiquitin and ubiquitin‐like proteins regulates almost all cellular processes, by affecting protein degradation, localization, and complex formation. Deubiquitinases (DUBs) are proteas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ec446fc3670b8e87db472f74b20c75a
https://doi.org/10.1111/febs.14039
https://doi.org/10.1111/febs.14039
Autor:
Wei-Ching Liang, Cecilia Chiu, Steven R. Leong, Angela Hendricks, Vanessa Clark, Andrew Polson, Yan Wu, Rajesh Vij, Jack Sadowsky, Wayne Chu, Thomas H. Pillow, John A. Flygare, Genee Y. Lee, Geoffrey Del Rosario, Melissa Schutten, Shang-Fan Yu, Kirsten Achilles Poon, Cecile Chalouni, Bing Zheng
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 25(4)
Purpose: The treatment of acute myeloid leukemia (AML) has not significantly changed in 40 years. Cytarabine- and anthracycline-based chemotherapy induction regimens (7 + 3) remain the standard of care, and most patients have poor long-term survival.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8889d91a81d4543f26032b1ad4f51a1b
https://pubmed.ncbi.nlm.nih.gov/29959143
https://pubmed.ncbi.nlm.nih.gov/29959143
Autor:
Leanna Staben, Klaus Koefoed, Helga Raab, Cecile Chalouni, Yana Khalfin, Laura DePalatis, Kelly M. Loyet, Thomas H. Pillow, Min Xu, Byoung-Chul Lee, Peter S. Andersen, Emile Plise, Janice Kim, Elizabeth Luis, Martine Darwish, Rina Fong, Man-Wah Tan, Eric J. Brown, Patrick J. Lupardus, J. Hiroshi Morisaki, Summer Park, Sophie M. Lehar, Donghong Yan, Richard Vandlen, Joseph P. Lyssikatos, Magnus Strandh, Wouter L. W. Hazenbos, John A. Flygare, Sanjeev Mariathasan, Kimberly Kajihara, Hilda Hernandez, Jonathan Cheong
Publikováno v:
Nature. 527:323-328
Staphylococcus aureus is considered to be an extracellular pathogen. However, survival of S. aureus within host cells may provide a reservoir relatively protected from antibiotics, thus enabling long-term colonization of the host and explaining clini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83140a68bee3ff5327a432f58cf3a1f8
https://doi.org/10.1038/nature16057
https://doi.org/10.1038/nature16057