Zobrazeno 1 - 10
of 121
pro vyhledávání: '"John A. Eccleston"'
Publikováno v:
Journal of Biopharmaceutical Statistics. 22:1193-1205
This study compared the performance of a local and three robust optimality criteria in terms of the standard error for a one-parameter and a two-parameter nonlinear model with uncertainty in the parameter values. The designs were also compared in con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf3405c95c956430c6701cf275cbb8d9
https://doi.org/10.1080/10543406.2011.580484
https://doi.org/10.1080/10543406.2011.580484
Autor:
Kerrie Mengersen, Christopher C. Drovandi, T. Goggin, Stephen B. Duffull, John A. Eccleston, James McGree, Anthony N. Pettitt, M.H. Thompson
Publikováno v:
Journal of Statistical Planning and Inference. 142:1480-1492
We consider the problem of how to efficiently and safely design dose finding studies. Both current and novel utility functions are explored using Bayesian adaptive design methodology for the estimation of a maximum tolerated dose (MTD). In particular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::deca7cfdc2fd87037f98b553d00c1fad
https://doi.org/10.1016/j.jspi.2011.12.029
https://doi.org/10.1016/j.jspi.2011.12.029
Autor:
John A. Eccleston, James McGree
Publikováno v:
Technometrics. 54:64-72
We consider the problem of how to construct robust designs for Poisson regression models. An analytical expression is derived for robust designs for first-order Poisson regression models where uncertainty exists in the prior parameter estimates. Give
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0216d7cfae4028ce0c77bcd18a6ca90c
https://doi.org/10.1080/00401706.2012.648867
https://doi.org/10.1080/00401706.2012.648867
Publikováno v:
Computational Statistics & Data Analysis. 55:1509-1520
Optimal design for generalized linear models has primarily focused on univariate data. Often experiments are performed that have multiple dependent responses described by regression type models, and it is of interest and of value to design the experi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::980c0044c0ebafca1847df61308a6e63
https://doi.org/10.1016/j.csda.2010.07.025
https://doi.org/10.1016/j.csda.2010.07.025
Autor:
Faith V. Mayer, Stephen R. Martin, David Carmena, Matthew J. Sanders, Bing Xiao, Rein Aasland, David Carling, Chun-Xia Jing, Steven Howell, Richard Heath, Peter Saiu, Elizabeth Underwood, Lesley F. Haire, John F. Eccleston, Steven J. Gamblin, Philip A. Walker
Publikováno v:
Nature
The heterotrimeric AMP-activated protein kinase (AMPK) has a key role in regulating cellular energy metabolism; in response to a fall in intracellular ATP levels it activates energy-producing pathways and inhibits energy-consuming processes. AMPK has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81e71bd24eac888f8a356411281a15de
http://europepmc.org/articles/PMC3078618
http://europepmc.org/articles/PMC3078618
Publikováno v:
Journal of Statistical Planning and Inference. 140:2719-2738
The efficient design of experiments for comparing a control with v new treatments when the data are dependent is investigated. We concentrate on generalized least-squares estimation for a known covariance structure. We consider block sizes k equal to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2804467c7d82e88ad2d1948182484638
https://doi.org/10.1016/j.jspi.2010.03.037
https://doi.org/10.1016/j.jspi.2010.03.037
Publikováno v:
Translational Research. 156:55-67
In iron overload conditions, plasma contains non-transferrin bound iron species, collectively referred to as plasma NTBI. These include iron citrate species, some of which are protein bound. Because NTBI is taken into tissues susceptible to iron load
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::514c3a5fccdee483e5d330bb78d69330
https://doi.org/10.1016/j.trsl.2010.05.002
https://doi.org/10.1016/j.trsl.2010.05.002
Autor:
John A. Eccleston, James McGree
Publikováno v:
Metrika. 72:295-311
The aim of this paper is to derive methodology for designing ‘time to event’ type experiments. In comparison to estimation, design aspects of ‘time to event’ experiments have received relatively little attention. We show that gains in efficie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4bff9caf66663cfd50696a970a7cc911
https://doi.org/10.1007/s00184-009-0254-3
https://doi.org/10.1007/s00184-009-0254-3
Publikováno v:
Journal of Pharmacokinetics and Pharmacodynamics. 36:101-123
We consider nested multiple response models which are used extensively in the area of pharmacometrics. Given the conditional nature of such models, differences in predicted responses are a consequence of different assumptions about how the models int
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d432eeddb2f904c931a2df67d0594458
https://doi.org/10.1007/s10928-009-9113-0
https://doi.org/10.1007/s10928-009-9113-0
Publikováno v:
Journal of Biopharmaceutical Statistics. 19:386-402
Nonlinear models are common in pharmacokinetics and pharmacodynamics. To date, most work in design in this area has concentrated on parameter estimation. Here, we introduce the idea of optimization of both estimation and model selection. However, exp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bc17b2366c028bdf3d76c18203424f2
https://doi.org/10.1080/10543400802677257
https://doi.org/10.1080/10543400802677257