Zobrazeno 1 - 10
of 13
pro vyhledávání: '"John A. Delyani"'
Autor:
Yuen-lung L. Sing, John A. Delyani, Dwain S. Tolbert, Chyung S. Cook, Brian Whelihan, Barbara Roniker, Stuart Levin, Diane Workman, Ricardo Rocha
Publikováno v:
Cardiovascular Drug Reviews. 19:185-200
Aldosterone, the final product of the renin-angiotensin-aldosterone system (RAAS), is a mineralocorticoid hormone that classically acts, via the mineralocorticoid (aldosterone) receptor, on epithelia of the kidneys, colon, and sweat glands to maintai
Autor:
Pochang Yang, Rachel Scherrer, John A. Delyani, Ricardo Rocha, Ellen G. McMahon, Cynthia L. Martin-Berger
Publikováno v:
Endocrinology. 143:4828-4836
We studied the role of aldosterone (aldo) in myocardial injury in a model of angiotensin (Ang) II-hypertension. Wistar rats were given 1% NaCl (salt) to drink and randomized into one of the following groups (n = 10; treatment, 21 d): 1) vehicle contr
Publikováno v:
Molecular and Cellular Endocrinology. 165:221-224
The steroid aldosterone plays a major role in the maintenance of total body sodium homeostasis and also contributes to cardiovascular pathophysiology by mediating cardiac hypertrophy and fibrosis. In addition to classical adrenal production of aldost
Autor:
John A. Delyani
Publikováno v:
Expert Opinion on Investigational Drugs. 7:753-759
Activation of the renin-angiotensin-aldosterone system (RAAS) is a prominent feature of left ventricular dysfunction and plays an important role in the progression of chronic heart failure. Clinical and animal studies investigating agents that interr
Publikováno v:
Journal of Leukocyte Biology. 59:317-324
Polymorphonuclear leukocytes (PMNs) play an important role in myocardial ischemia/reperfusion (MI/R) injury. We examined the cardioprotective effects of N,N,N-trimethylsphingosine (TMS) in a murine model of MI (20 min) and R (24 h) injury in vivo, fo
Autor:
John A. Delyani, Ellen G. Mcmahon, Eric A.G. Blomme, Denise A. Nachowiak, Beverly K. Kekec, Ricardo Rocha, Gregory E. Frierdich, Amy E. Rudolph
Publikováno v:
American journal of physiology. Heart and circulatory physiology. 283(5)
Vascular inflammation was examined as a potential mechanism of aldosterone-mediated myocardial injury in uninephrectomized rats receiving 1% NaCl-0.3% KCl to drink for 1, 2, or 4 wk and 1) vehicle, 2) aldosterone infusion (0.75 μg/h), or 3) aldoster
Publikováno v:
American journal of physiology. Heart and circulatory physiology. 281(2)
Myocardial infarction (MI) initiates adaptive tissue remodeling, which is essential for heart function (such as infarct healing) but is also important for maladaptive remodeling (for example, reactive fibrosis and left ventricular dilation). The effe
Publikováno v:
Journal of molecular and cellular cardiology. 28(5)
Although several studies have demonstrated that chronic exposure to estrogen appears to be cardioprotective, acute circulatory effects of estrogen are largely unknown. Therefore, we studied the effects of acute administration of 17 beta-estradiol in
Publikováno v:
The American journal of physiology. 270(3 Pt 2)
We studied the potential cardioprotective effects of the novel recombinant serine protease inhibitor (serpin), LEX-032, which inhibits the serine proteases elastase and cathepsin G. LEX-032 is a recombinant construct of human alpha 1-antichymotrypsin
Autor:
John A. Delyani
Publikováno v:
Journal of Molecular and Cellular Cardiology. 33:A26