Zobrazeno 1 - 10
of 431
pro vyhledávání: '"John A. Curtin"'
Autor:
Mauro Tutino, Jenny Hankinson, Clare Murray, Lesley Lowe, Gina Kerry, Magnus Rattray, Adnan Custovic, Sebastian L. Johnston, Chenfu Shi, Gisela Orozco, Stephen Eyre, Paul Martin, Angela Simpson, John A. Curtin
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023)
Abstract Functional enrichment analysis of genome-wide association study (GWAS)-summary statistics has suggested that CD4+ T-cells play an important role in asthma pathogenesis. Despite this, CD4+ T-cells are under-represented in asthma transcriptome
Externí odkaz:
https://doaj.org/article/c7ac37edc530414aabe9f0ab3891436c
Autor:
Lijing Lin, John A. Curtin, Eteri Regis, Aurica Hirsman, Rebecca Howard, Mauro Tutino, Michael R. Edwards, Mattia Prosperi, Angela Simpson, Magnus Rattray, Adnan Custovic, Sebastian L. Johnston
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Patterns of human immune responses to viruses and bacteria and how this impacts risk of infections or onset/exacerbation of chronic respiratory diseases are poorly understood. In a population-based birth cohort, we measured peripheral blood
Externí odkaz:
https://doaj.org/article/962569f4566642efb4f9f8b58782ec23
Autor:
Eteri Regis, Sara Fontanella, Lijing Lin, Rebecca Howard, Sadia Haider, John A. Curtin, Michael R. Edwards, Magnus Rattray, Angela Simpson, Adnan Custovic, Sebastian L. Johnston
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract The mechanisms explaining excess morbidity and mortality in respiratory infections among males are poorly understood. Innate immune responses are critical in protection against respiratory virus infections. We hypothesised that innate immune
Externí odkaz:
https://doaj.org/article/e667c858cf0341aaa467bae5485baa98
Autor:
Sarah Grosche, Ingo Marenholz, Jorge Esparza-Gordillo, Aleix Arnau-Soler, Erola Pairo-Castineira, Franz Rüschendorf, Tarunveer S. Ahluwalia, Catarina Almqvist, Andreas Arnold, Australian Asthma Genetics Consortium (AAGC), Hansjörg Baurecht, Hans Bisgaard, Klaus Bønnelykke, Sara J. Brown, Mariona Bustamante, John A. Curtin, Adnan Custovic, Shyamali C. Dharmage, Ana Esplugues, Mario Falchi, Dietmar Fernandez-Orth, Manuel A. R. Ferreira, Andre Franke, Sascha Gerdes, Christian Gieger, Hakon Hakonarson, Patrick G. Holt, Georg Homuth, Norbert Hubner, Pirro G. Hysi, Marjo-Riitta Jarvelin, Robert Karlsson, Gerard H. Koppelman, Susanne Lau, Manuel Lutz, Patrik K. E. Magnusson, Guy B. Marks, Martina Müller-Nurasyid, Markus M. Nöthen, Lavinia Paternoster, Craig E. Pennell, Annette Peters, Konrad Rawlik, Colin F. Robertson, Elke Rodriguez, Sylvain Sebert, Angela Simpson, Patrick M. A. Sleiman, Marie Standl, Dora Stölzl, Konstantin Strauch, Agnieszka Szwajda, Albert Tenesa, Philip J. Thompson, Vilhelmina Ullemar, Alessia Visconti, Judith M. Vonk, Carol A. Wang, Stephan Weidinger, Matthias Wielscher, Catherine L. Worth, Chen-Jian Xu, Young-Ae Lee
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Genetic studies of eczema to date have mostly explored common genetic variation. Here, the authors perform a large meta-analysis for common and rare variants and discover 8 loci associated with eczema. Over 20% of the heritability of the condition is
Externí odkaz:
https://doaj.org/article/d54f293b9f924ec89242fe90b53feed8
Autor:
Dilini M. Kothalawala, Latha Kadalayil, John A. Curtin, Clare S. Murray, Angela Simpson, Adnan Custovic, William J. Tapper, S. Hasan Arshad, Faisal I. Rezwan, John W. Holloway, on behalf of STELAR/UNICORN investigators
Publikováno v:
Journal of Personalized Medicine, Vol 12, Iss 1, p 75 (2022)
Genome-wide and epigenome-wide association studies have identified genetic variants and differentially methylated nucleotides associated with childhood asthma. Incorporation of such genomic data may improve performance of childhood asthma prediction
Externí odkaz:
https://doaj.org/article/ee13352a5a854bd384ff0498795f73e5
Autor:
Hyung Cho Kim, Claire M Kaplan, Samiha Islam, Allegra S Anderson, Megan E Piper, Daniel E Bradford, John J Curtin, Kathryn A DeYoung, Jason F Smith, Andrew S Fox, Alexander J Shackman
Publikováno v:
PLoS ONE, Vol 18, Iss 7, p e0288544 (2023)
Tobacco smoking imposes a staggering burden on public health, underscoring the urgency of developing a deeper understanding of the processes that maintain addiction. Clinical and experience-sampling data highlight the importance of anxious withdrawal
Externí odkaz:
https://doaj.org/article/dcb8d0e6e63a4f8084603a83497bf35c
Publikováno v:
Infectious Disease Clinics of North America. 37:223-243
Autor:
Mauro Tutino, Raquel Granell, John A. Curtin, Sadia Haider, Sara Fontanella, Clare S. Murray, Graham Roberts, S. Hasan Arshad, Stephen Turner, Andrew P. Morris, Adnan Custovic, Angela Simpson
Publikováno v:
STELAR/UNICORN investigators 2023, ' Dog ownership in infancy is protective for persistent wheeze in 17q21 asthma-risk carriers ', The Journal of allergy and clinical immunology, vol. 151, no. 2, pp. 423-430 . https://doi.org/10.1016/j.jaci.2022.10.012
Tutino, M, Granell, R, Curtin, J A, Haider, S, Fontanella, S, Murray, C S, Roberts, G, Arshad, S H, Turner, S, Morris, A P & Custovic, A & Simpson, A 2022, ' Dog ownership in infancy is protective for persistent wheeze in 17q21 asthma-risk carriers ', Journal of Allergy and Clinical Immunology . https://doi.org/10.1016/j.jaci.2022.10.012
STELAR/UNICORN investigators 2022, ' Dog ownership in infancy is protective for persistent wheeze in 17q21 asthma-risk carriers ', Journal of Allergy and Clinical Immunology . https://doi.org/10.1016/j.jaci.2022.10.012
Tutino, M, Granell, R, Curtin, J A, Haider, S, Fontanella, S, Murray, C S, Roberts, G, Arshad, S H, Turner, S, Morris, A P & Custovic, A & Simpson, A 2022, ' Dog ownership in infancy is protective for persistent wheeze in 17q21 asthma-risk carriers ', Journal of Allergy and Clinical Immunology . https://doi.org/10.1016/j.jaci.2022.10.012
STELAR/UNICORN investigators 2022, ' Dog ownership in infancy is protective for persistent wheeze in 17q21 asthma-risk carriers ', Journal of Allergy and Clinical Immunology . https://doi.org/10.1016/j.jaci.2022.10.012
BackgroundAsthma-associated single nucleotide polymorphisms from large genome-wide association studies only explain a fraction of genetic heritability. Likely causes of the missing heritability include broad phenotype definitions and gene-environment
Evolution of Eczema, Wheeze, and Rhinitis from Infancy to Early Adulthood: Four Birth Cohort Studies
Autor:
Sadia Haider, Sara Fontanella, Anhar Ullah, Stephen Turner, Angela Simpson, Graham Roberts, Clare S. Murray, John W. Holloway, John A. Curtin, Paul Cullinan, Syed Hasan Arshad, Guillem Hurault, Raquel Granell, Adnan Custovic, John Ainsworth, Andrew Boyd, Philip Couch, Graham Devereux, Ibrahim Emam, Yi-ke Guo, Sejal Saglani, Ashley Woodcock
Publikováno v:
Haider, S, Fontanella, S, Granell, R & Custovic, A 2022, ' Evolution of Eczema, Wheeze and Rhinitis from Infancy to Early Adulthood: Four Birth Cohort Studies ', American Journal of Respiratory and Critical Care Medicine, vol. 206, no. 8, pp. 950-960 . https://doi.org/10.1164/rccm.202110-2418OC
Am J Respir Crit Care Med
STELAR/UNICORN investigators 2022, ' Evolution of Eczema, Wheeze, and Rhinitis from Infancy to Early Adulthood Four Birth Cohort Studies ', American Journal of Respiratory and Critical Care Medicine, vol. 206, no. 8, pp. 950-960 . https://doi.org/10.1164/RCCM.202110-2418OC
Am J Respir Crit Care Med
STELAR/UNICORN investigators 2022, ' Evolution of Eczema, Wheeze, and Rhinitis from Infancy to Early Adulthood Four Birth Cohort Studies ', American Journal of Respiratory and Critical Care Medicine, vol. 206, no. 8, pp. 950-960 . https://doi.org/10.1164/RCCM.202110-2418OC
Rationale: The relationship between eczema, wheeze or asthma, and rhinitis is complex, and epidemiology and mechanisms of their comorbidities is unclear. Objectives: To investigate within-individual patterns of morbidity of eczema, wheeze, and rhinit
Autor:
Robert J. Schneider, Stephanie V. Blank, John P. Curtin, Gizelka David-West, Amandine Alard, Fernanda Musa
There is considerable interest in the clinical development of inhibitors of mTOR complexes mTORC1 and 2. Because mTORC1 and its downstream mRNA translation effectors may protect against genotoxic DNA damage, we investigated the inhibition of mTORC1 a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f8385a263a1af40f37ae5ad8d386225
https://doi.org/10.1158/1535-7163.c.6538689.v1
https://doi.org/10.1158/1535-7163.c.6538689.v1