Zobrazeno 1 - 10
of 588
pro vyhledávání: '"John A. Connor"'
Autor:
Adam J. Hume, Dylan J. Deeney, John S. Smetana, Jacquelyn Turcinovic, John H. Connor, Marlene Belfort, Elke Mühlberger, Christopher W. Lennon
Publikováno v:
mBio, Vol 15, Iss 6 (2024)
ABSTRACT Intervening proteins (inteins) are translated as subdomains within host proteins and removed through an intein-driven splicing reaction where the flanking sequences (exteins) are joined with a peptide bond. Previously, we developed a self-re
Externí odkaz:
https://doaj.org/article/de4e8bdb72b6499c8d080224ab36e8e1
Autor:
Qing Xia, Zhongyue Guo, Haonan Zong, Scott Seitz, Celalettin Yurdakul, M. Selim Ünlü, Le Wang, John H. Connor, Ji-Xin Cheng
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract Clinical identification and fundamental study of viruses rely on the detection of viral proteins or viral nucleic acids. Yet, amplification-based and antigen-based methods are not able to provide precise compositional information of individu
Externí odkaz:
https://doaj.org/article/218542972acc45938a7e29b2c2c565ab
Autor:
Stephen J. Ross, Adam J. Hume, Judith Olejnik, Jacquelyn Turcinovic, Anna N. Honko, Lindsay G. A. McKay, John H. Connor, Anthony Griffiths, Elke Mühlberger, Daniel Cifuentes
Publikováno v:
Viruses, Vol 16, Iss 7, p 1064 (2024)
Although next-generation sequencing (NGS) has been instrumental in determining the genomic sequences of emerging RNA viruses, de novo sequence determination often lacks sufficient coverage of the 5′ and 3′ ends of the viral genomes. Since the gen
Externí odkaz:
https://doaj.org/article/af4be9266d694121958cb9c7fd2df16f
Autor:
Victoria Overbeck, Bradford P. Taylor, Jacquelyn Turcinovic, Xueting Qiu, Beau Schaeffer, Scott Seitz, Scott R. Curry, William P. Hanage, John H. Connor, Krutika Kuppalli
Publikováno v:
Heliyon, Vol 10, Iss 1, Pp e23699- (2024)
Background: Immunocompromised patients receiving B-cell-depleting therapies are at increased risk of persistent SARS-CoV-2 infection, with many experiencing fatal outcomes. We report a successful outcome in a patient with rheumatoid arthritis (RA) on
Externí odkaz:
https://doaj.org/article/9d0297be99844833b7bca6b7f072d815
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Monoclonal antibodies (mAbs) play an important role in diagnostics and therapy of infectious diseases. Here we utilize a single-particle interferometric reflectance imaging sensor (SP-IRIS) for screening 30 mAbs against Ebola, Sudan, and Las
Externí odkaz:
https://doaj.org/article/2a870e3a18cb407b89888b860d06064e
Autor:
Da-Yuan Chen, Jacquelyn Turcinovic, Shuchen Feng, Devin J. Kenney, Chue Vin Chin, Manish C. Choudhary, Hasahn L. Conway, Marc Semaan, Brianna J. Close, Alexander H. Tavares, Scott Seitz, Nazimuddin Khan, Sebastian Kapell, Nicholas A. Crossland, Jonathan Z. Li, Florian Douam, Susan C. Baker, John H. Connor, Mohsan Saeed
Publikováno v:
iScience, Vol 26, Iss 5, Pp 106634- (2023)
Summary: A simple and robust cell culture system is essential for generating authentic SARS-CoV-2 stocks for evaluation of viral pathogenicity, screening of antiviral compounds, and preparation of inactivated vaccines. Evidence suggests that Vero E6,
Externí odkaz:
https://doaj.org/article/4ef512ed285e4127ae84089843aedd7f
Autor:
Adam J. Hume, Judith Olejnik, Mitchell R. White, Jessie Huang, Jacquelyn Turcinovic, Baylee Heiden, Pushpinder S. Bawa, Christopher J. Williams, Nickolas G. Gorham, Yuriy O. Alekseyev, John H. Connor, Darrell N. Kotton, Elke Mühlberger
Publikováno v:
Pathogens, Vol 13, Iss 1, p 62 (2024)
Single-cell RNA sequencing (scRNA-seq) technologies are instrumental to improving our understanding of virus–host interactions in cell culture infection studies and complex biological systems because they allow separating the transcriptional signat
Externí odkaz:
https://doaj.org/article/73c0987378d64d07b63bcbae717fefc9
Autor:
Lena Landaverde, Jacquelyn Turcinovic, Lynn Doucette-Stamm, Kevin Gonzales, Judy Platt, John H. Connor, Catherine Klapperich
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 6 (2022)
ABSTRACT The COVID-19 pandemic has increased use of rapid diagnostic tests (RDTs). In winter 2021 to 2022, the Omicron variant surge made it apparent that although RDTs are less sensitive than quantitative reverse transcription-PCR (qRT-PCR), the acc
Externí odkaz:
https://doaj.org/article/5fbe8a6ba5f649609f9285189df9d3a2
Autor:
Jacquelyn Turcinovic, Kayla Kuhfeldt, Madison Sullivan, Lena Landaverde, Judy T. Platt, Lynn Doucette-Stamm, William P. Hanage, Davidson H. Hamer, Catherine Klapperich, Hannah E. Landsberg, John H. Connor
Publikováno v:
iScience, Vol 25, Iss 11, Pp 105337- (2022)
Summary: Contact tracing and genomic data, approaches often used separately, have both been important tools in understanding the nature of SARS-CoV-2 transmission. Linked analysis of contact tracing and sequence relatedness of SARS-CoV-2 genomes from
Externí odkaz:
https://doaj.org/article/2e56e3922e554640898d496531550dcb
Autor:
Hannah E. Landsberg, MSN, MPH, Jacquelyn Turcinovic, B.S., Madison Sullivan, MPH, John H. Connor, Ph.D., Davidson H. Hamer, MD, Judy T. Platt, MD
Publikováno v:
International Journal of Infectious Diseases, Vol 114, Iss , Pp 62-64 (2022)
ABSTRACT: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) sublineage B.1.617.2 or Delta, a variant that began circulating in India and is becoming dominant in the USA, has been responsible for significant morbidity and mortality. In May
Externí odkaz:
https://doaj.org/article/52bd5f1be98c4a7b8d31ec631ce2ec32