Zobrazeno 1 - 10 of 315 pro vyhledávání: '"John A. Brinkman"'
6
Clinical and Metabolic Correlates of Pure Stone Subtypes
Autor: Christa L. Stoughton, John E. Brinkman, Amy E. Krambeck, Charles U. Nottingham, Tim Large
Publikováno v: Journal of endourology. 35(10)
Background: There are multiple stone types, with each forming under different urinary conditions. We compared clinical and metabolic findings in pure stone formers (SFs) to understand whether there...
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba9b1de081971baefc0eb9747312e832
https://pubmed.ncbi.nlm.nih.gov/33573466
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7
4-Substituted-7-N-alkyl-N-acetyl 2-aminobenzothiazole amides: Drug-like and non-xanthine based A2B adenosine receptor antagonists
Autor: Rachid Hamid, Roger David Norcross, Mary Lou Gubler, Ramakanth Sarabu, Fariborz Firooznia, Adrian Wai-Hing Cheung, John A. Brinkman, Nicholas Marcopulos, Lida Qi, Kevin Richard Guertin, Alexander Flohr, Jenny Tan, Gwendolyn Ramsey, Joseph Grimsby, Yang Wen
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 20:4140-4146
7-N-Acetamide-4-methoxy-2-aminobenzothiazole 4-fluorobenzamide (compound 1) was chosen as a drug-like and non-xanthine based starting point for the discovery of A(2B) receptor antagonists because of its slight selectivity against A(1) and A(2A) recep
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2103d066fa21cacca11962d6d1f7caf
https://doi.org/10.1016/j.bmcl.2010.05.056
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8
NEUROPSYCHOLOGICAL MEASURES AND SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY IN THE DIFFERENTIATION AND CLASSIFICATION OF CEREBRAL PERFUSION DEFICITS IN ALZHEIMER'S DEMENTIA
Autor: Raymond S. Dean, Andrew S. Davis, John J. Brinkman, Mark G. Moren
Publikováno v: International Journal of Neuroscience. 115:1131-1149
The accurate diagnosis of Dementia of the Alzheimer's Type (DAT) continues to be an area of difficulty for the fields of neuropsychology and neurology. The introduction of new medications that appear to mediate the insidious progression of the disord
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29de0d9843f58ac9990e965178f58c57
https://doi.org/10.1080/00207450590914428
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9
1-[2-[(5-Cyanopyridin-2-yl)amino]ethylamino]acetyl-2-(S)-pyrrolidinecarbonitrile: A Potent, Selective, and Orally Bioavailable Dipeptidyl Peptidase IV Inhibitor with Antihyperglycemic Properties
Autor: Edwin Bernard Villhauer, Thomas Edward Hughes, John A Brinkman, Manisha Mone, Bonnie L Mangold, Mary E Russell, Goli B Naderi, Stephen Craig Weldon, Beth E. Dunning
Publikováno v: Journal of Medicinal Chemistry. 45:2362-2365
Dipeptidyl peptidase IV (DPP-IV) inhibition has the potential to become a valuable therapy for type 2 diabetes. We report the first use of solid-phase synthesis in the discovery of a new DPP-IV inhibitor class and a solution-phase synthesis that is p
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1a23159d1dca769374d0d90eb53fdcb
https://doi.org/10.1021/jm025522z
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10
Squalene synthase inhibitors: isosteric replacements of the farnesyl chain of benzyl farnesyl amine
Autor: Terence J. Scallen, T.R. Vedamanda, John A. Brinkman, Lawerence B. Perez, Fell Jay Bradford, Robert E. Damon
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 6:2491-2494
Squalene synthase catalyzes the committed step of cholesterol biosynthesis. We report here the synthesis and in vivo activity of a series of squalene synthase inhibitors that contain isosteric replacements for the farnesyl chain of the known inhibito
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::35c5514431de397813b7580cc7fdc7cf
https://doi.org/10.1016/0960-894x(96)00470-2
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