Zobrazeno 1 - 10
of 79
pro vyhledávání: '"John A. Brailsford"'
Publikováno v:
Journal of labelled compoundsradiopharmaceuticalsREFERENCES. 63(13)
N-(3-Dimethylaminopropyl)-N'-ethylcarbodiimide (EDC) is a carbodiimide coupling reagent commonly used for the preparation of amides from carboxylic acids and amines. Because of initial concerns regarding the genotoxicity of EDC and its use in GMP syn
Autor:
James William Bryson, Wai Leung Lau, John A. Brailsford, Miguel Moreta, Julie Su, Virginie Lafont, Martin C. Wright, Michael J. Smith, H. Nicholas Marsh, Anthony Barros, Sanjeev Gangwar, Jason Pinckney, Qiang Cong, Alban Allentoff, Christina Terragni, Dasa Lipovsek, Pete Z. Cotter, Michael Wallace, Irvith M. Carvajal, Cris Hollander, Wenying Li, O'neil Steven, Lifei Wang
Publikováno v:
Protein Engineering, Design and Selection
Tumor-specific delivery of cytotoxic agents remains a challenge in cancer therapy. Antibody–drug conjugates (ADC) deliver their payloads to tumor cells that overexpress specific tumor-associated antigens—but the multi-day half-life of ADC leads t
Autor:
John A. Brailsford, Jennifer L. Stockdill, Eric V. Johnston, Abram J. Axelrod, Paul A. Vadola, Samuel J. Danishefsky, Michael T. Peterson
Publikováno v:
Tetrahedron. 74:1951-1956
The β-subunit of human thyroid stimulating hormone (hTSH) has been synthesized as a single glycoform bearing a chitobiose disaccharide at the native glycosylation site. Key to the successful completion of this synthesis was the introduction of an ar
Autor:
Janet Caceres-Cortes, Kai Cao, Robert Espina, John A. Brailsford, Ming Yao, Samuel J. Bonacorsi
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 60:150-159
Two regioisomeric glucuronide metabolites of dapagliflozin (BMS-512148) were synthesized and used to elucidate the structures of dapagliflozin metabolites observed in human urine samples. The structures of the synthetic metabolites were assigned by h
Autor:
Adrienne A. Tymiak, Sike Chen, Chunlei Wang, Aaron P. Yamniuk, Yingru Zhang, John A. Brailsford
Publikováno v:
Journal of Chromatography A. 1426:133-139
Two dimensional liquid chromatography (2D-LC) coupling size exclusion (SEC) and hydrophilic interaction chromatography (HILIC) is demonstrated as a useful tool to study polar excipients, such as histidine and its degradant, in protein formulation sam
Autor:
Alban Allentoff, John A. Brailsford, Michael Wallace, Frank Rinaldi, Samuel J. Bonacorsi, Sharon Gong
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 58:429-432
2-Iminothiolane has found utility in the growing area of antibody-drug conjugates by serving as a lysine-thiolating agent and the junction between the antibody and the cytotoxic payload during random conjugation of a monoclonal antibody. 2-(14)C-Imin
Publikováno v:
Organic Letters. 16:4460-4463
Progress toward the welwitindolinone alkaloid N-methylwelwitindolinone B isothiocyanate is reported. A key reaction to synthesize the [4.3.1] bicycle embedded in the core of the molecule is a furan type 2 intramolecular Diels-Alder reaction with a te
Publikováno v:
The Journal of Organic Chemistry. 72:9402-9405
The type 2 intramolecular Diels-Alder (IMDA) reaction is a valuable method for synthesis of both carbocyclic and heterocyclic bridged bicyclo[5.3.1]undecane and bicyclo[4.3.1]decane ring systems. These structures are common to a number of biologicall
Autor:
John A. Brailsford, Alberto Fernández-Tejada, Jae-Hung Shieh, Malcolm A.S. Moore, Samuel J. Danishefsky, Qiang Zhang
Publikováno v:
Protein Ligation and Total Synthesis I ISBN: 9783319191850
Glycoproteins are an important class of naturally occurring biomolecules which play a pivotal role in many biological processes. They are biosynthesized as complex mixtures of glycoforms through post-translational protein glycosylation. This fact, to
Publikováno v:
Journal of Family Issues. 24:966-980
Relations between identity formation and family characteristics among young adults were examined. The Family Adaptability and Cohesion Evaluation Scales II and the Ego Process Questionnaire were administered to 57 male and 94 female college students