Zobrazeno 1 - 10
of 132
pro vyhledávání: '"John A. Bilello"'
Autor:
Yuxia Lin, Mona Khan, Birgit Weynand, Manon Laporte, Frank Coenjaerts, Darius Babusis, John P. Bilello, Peter Mombaerts, Dirk Jochmans, Johan Neyts
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Human parainfluenza virus type 3 (HPIV-3) can cause severe respiratory tract infections. There are no convenient small-animal infection models. Here, we show viral replication in the upper and lower airways of AG129 mice (double IFNα/β and
Externí odkaz:
https://doaj.org/article/3b9f33250d7041cd861db0e822ff8a0c
Autor:
Sheli R. Radoshitzky, Patrick Iversen, Xianghan Lu, Jing Zou, Suzanne J. F. Kaptein, Kelly S. Stuthman, Sean A. Van Tongeren, Jesse Steffens, Ruoyu Gong, Hoa Truong, Annapurna A. Sapre, Huiling Yang, Xiaodong Xie, Jia Jun Chia, Zhijuan J. Song, Stacey M. Leventhal, Josolyn Chan, Alex Shornikov, Xin Zhang, David Cowfer, Helen Yu, Travis Warren, Tomas Cihlar, Danielle P. Porter, Johan Neyts, Pei-Yong Shi, Jay Wells, John P. Bilello, Joy Y. Feng
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Remdesivir (GS-5734; VEKLURY) is a single diastereomer monophosphoramidate prodrug of an adenosine analog (GS-441524). Remdesivir is taken up by target cells and metabolized in multiple steps to form the active nucleoside triphosphate (GS-44
Externí odkaz:
https://doaj.org/article/ee7f5fe788f0477a9009a8f32e4eeffd
Autor:
Robert M. Cox, Josef D. Wolf, Carolin M. Lieber, Julien Sourimant, Michelle J. Lin, Darius Babusis, Venice DuPont, Julie Chan, Kim T. Barrett, Diane Lye, Rao Kalla, Kwon Chun, Richard L. Mackman, Chengjin Ye, Tomas Cihlar, Luis Martinez-Sobrido, Alexander L. Greninger, John P. Bilello, Richard K. Plemper
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Remdesivir is an approved antiviral treatment for COVID-19, but it needs to be administered intravenously. Here, Cox et al. show that GS-621763, a prodrug of remdesivir parent nucleoside GS-441524 has good oral bioavailability and inhibits SARS-CoV-2
Externí odkaz:
https://doaj.org/article/480b9bcf109e47b7bd2093b34d9f4683
Autor:
Xuping Xie, Antonio E. Muruato, Xianwen Zhang, Kumari G. Lokugamage, Camila R. Fontes-Garfias, Jing Zou, Jianying Liu, Ping Ren, Mini Balakrishnan, Tomas Cihlar, Chien-Te K. Tseng, Shinji Makino, Vineet D. Menachery, John P. Bilello, Pei-Yong Shi
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
A high-throughput platform would greatly facilitate coronavirus disease 2019 (COVID-19) serological testing and antiviral screening. To address this, Shi and colleagues present a high-throughput nanoluciferase severe respiratory syndrome coronavirus
Externí odkaz:
https://doaj.org/article/2bbb94f095f34ea1ad62d72c16d57318
Autor:
Joy Y. Feng, Venice Du Pont, Darius Babusis, Calvin J. Gordon, Egor P. Tchesnokov, Jason K. Perry, Vincent Duong, Arya Vijjapurapu, Xiaofeng Zhao, Julie Chan, Cal Cohen, Kavita Juneja, Tomas Cihlar, Matthias Götte, John P. Bilello
Publikováno v:
Molecules, Vol 27, Iss 13, p 4212 (2022)
The urgent response to the COVID-19 pandemic required accelerated evaluation of many approved drugs as potential antiviral agents against the causative pathogen, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Using cell-based, biochemi
Externí odkaz:
https://doaj.org/article/8efa8d1cc25f4a15b4af0c4caa0f1353
Autor:
Brandon F. Malone, Jason K. Perry, Paul Dominic B. Olinares, Hery W. Lee, James Chen, Todd C. Appleby, Joy Y. Feng, John P. Bilello, Honkit Ng, Johanna Sotiris, Mark Ebrahim, Eugene Y. D. Chua, Joshua H. Mendez, Ed T. Eng, Robert Landick, Matthias Götte, Brian T. Chait, Elizabeth A. Campbell, Seth A. Darst
Publikováno v:
Nature. 614:781-787
Autor:
Richard L. Mackman, Rao Kalla, Darius Babusis, Jared Pitts, Kimberly T. Barrett, Kwon Chun, Venice Du Pont, Lauren Rodriguez, Jasmine Moshiri, Yili Xu, Michael Lee, Gary Lee, Blake Bleier, Anh-Quan Nguyen, B. Michael O’Keefe, Andrea Ambrosi, Meredith Cook, Joy Yu, Elodie Dempah, Elaine Bunyan, Nicholas C. Riola, Xianghan Lu, Renmeng Liu, Ashley Davie, Tien-Ying Hsiang, Michael Gale, Anita Niedziela-Majka, Joy Y. Feng, Charlotte Hedskog, John P. Bilello, Raju Subramanian, Tomas Cihlar
Remdesivir1is an amidate prodrug that releases the monophosphate of nucleoside GS-441524 (2) into lung cells thereby forming the bioactive triphosphate2-NTP.2-NTP, an analog of ATP, inhibits the SARS-CoV-2 RNA-dependent RNA polymerase replication and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f124f071d22852c94170b2ccfc17e415
https://doi.org/10.1101/2023.04.28.538473
https://doi.org/10.1101/2023.04.28.538473
Autor:
Xuping Xie, Antonio E. Muruato, Xianwen Zhang, Kumari G. Lokugamage, Camila R. Fontes-Garfias, Jing Zou, Jianying Liu, Ping Ren, Mini Balakrishnan, Tomas Cihlar, Chien-Te K. Tseng, Shinji Makino, Vineet D. Menachery, John P. Bilello, Pei-Yong Shi
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/5bcace2bce144897896504eaa9828c77
Autor:
John P. Bilello, Darius Babusis, Michelle J. Lin, Venice DuPont, Carolin M. Lieber, Kwon Soo Chun, Kim T. Barrett, Chengjin Ye, Robert M. Cox, Rao Kalla, Tomas Cihlar, Diane Lye, Alexander L. Greninger, Josef D. Wolf, Richard L. Mackman, Richard K. Plemper, Julien Sourimant, Luis Martinez-Sobrido, Julie Chan
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Nature Communications
Nature Communications
Remdesivir is an antiviral approved for COVID-19 treatment, but its wider use is limited by intravenous delivery. An orally bioavailable remdesivir analog may boost therapeutic benefit by facilitating early administration to non-hospitalized patients
Autor:
Michel Perron, Xiaofeng Zhao, Richard L. Mackman, Robert Jordan, Daniel Byun, Raju Subramanian, Tomas Cihlar, Kwon Soo Chun, Diane Lye, Christopher A. Palmiotti, Darius Babusis, Hui Hon Chung, Scott Simonovich, Bin Ma, Sarah Wortman, Lijun Zhang, Gary Lee, Julie Chan, Maria M. Toteva, Eisuke Murakami, Kirsten M. Stray, Xianghan Lu, Jared Pitts, Dustin Siegel, John P. Bilello, Kimberly T. Barrett, Bindu Goyal, Cynthia Kim, Arya Vijjapurapu, Venice Du Pont, Adelle Vandersteen
Publikováno v:
Journal of Medicinal Chemistry. 64:5001-5017
A discovery program targeting respiratory syncytial virus (RSV) identified C-nucleoside 4 (RSV A2 EC50 = 530 nM) as a phenotypic screening lead targeting the RSV RNA-dependent RNA polymerase (RdRp). Prodrug exploration resulted in the discovery of re