Výsledky vyhledávání - "John A. Melick"

Mri Assessment of Cerebral Blood Flow after Experimental Traumatic Brain Injury Combined with Hemorrhagic Shock in Mice

Autor: Lesley M. Foley, Patrick M. Kochanek, Stephen R. Wisniewski, Chien Ho, John A. Melick, Larry W. Jenkins, Alia M Iqbal O'Meara, T. Kevin Hitchens

Publikováno v: Journal of Cerebral Blood Flow & Metabolism. 33:129-136

Secondary insults such as hypotension or hemorrhagic shock (HS) can greatly worsen outcome after traumatic brain injury (TBI). We recently developed a mouse combined injury model of TBI and HS using a controlled cortical impact (CCI) model and showed

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f0b918d7fac26edc5ea2bf487419e06
https://doi.org/10.1038/jcbfm.2012.145

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Mild hypothermia decreases fentanyl and midazolam steady-state clearance in a rat model of cardiac arrest

Autor: Samuel M. Poloyac, Philip E. Empey, Tricia M. Miller, Ashley Philbrick, John A. Melick, Patrick M. Kochanek

Publikováno v: Critical Care Medicine. 40:1221-1228

OBJECTIVES Therapeutic hypothermia is widely employed for neuroprotection after cardiac arrest. However, concern regarding elevated drug concentrations during hypothermia and increased adverse drug reaction risk complicates concurrent pharmacotherapy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8192a89c5613e3b01cc23df63d14bcf
https://doi.org/10.1097/ccm.0b013e31823779f9

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Automated detection and characterization of SPIO-labeled cells and capsules using magnetic field perturbations

Autor: Qing Ye, Patrick M. Kochanek, Thomas M. Link, Joe D. Thompson, Wesley D. Gilson, Jeff W.M. Bulte, Clifford R. Weiss, Chien Ho, Eric T. Ahrens, T. Kevin Hitchens, Parker H. Mills, John A. Melick, Aravind Arepally, Lesley M. Foley

Publikováno v: Magnetic Resonance in Medicine. 67:278-289

Understanding how individual cells behave inside living systems will help enable new diagnostic tools and cellular therapies. Superparamagnetic iron oxide (SPIO) particles can be used to label cells and theranostic capsules for non-invasive tracking

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::981a5c4997f86394f07dfa338d5d33b9
https://doi.org/10.1002/mrm.22998

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Blood–brain barrier integrity in a rat model of emergency preservation and resuscitation

Autor: Jason Stezoski, Patrick M. Kochanek, Samuel A. Tisherman, Tomas Drabek, John A. Melick, Manuella Lahoud-Rahme

Publikováno v: Resuscitation. 80:484-488

Emergency Preservation and Resuscitation (EPR) represents a novel approach to treat exsanguination cardiac arrest (CA) victims, using an aortic flush to induce hypothermia during circulatory arrest, followed by delayed resuscitation with cardiopulmon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4de7b2fe5381c8e39a74181a7785605d
https://doi.org/10.1016/j.resuscitation.2009.01.007

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A dual role for poly-ADP-ribosylation in spatial memory acquisition after traumatic brain injury in mice involving NAD+ depletion and ribosylation of 14-3-3γ

Autor: Robert S. B. Clark, Larry W. Jenkins, Margaret A. Satchell, John A. Melick, Csaba Szabó, Patrick M. Kochanek, C. Edward Dixon, Xiaopeng Zhang

Publikováno v: Journal of Neurochemistry. 85:697-708

Poly(ADP-ribose) polymerase-1 (PARP-1) is a homeostatic enzyme that paradoxically contributes to disturbances in spatial memory acquisition after traumatic brain injury (TBI) in transgenic mice, thought to be related to depletion of its substrate nic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c7a2855c4f710fd3ab6f6b97a0af43cd
https://doi.org/10.1046/j.1471-4159.2003.01707.x

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Administration of adenosine receptor agonists or antagonists after controlled cortical impact in mice: effects on function and histopathology

Autor: Edwin K. Jackson, Patrick M. Kochanek, Vincent Vagni, Larry W. Jenkins, Manu R. Varma, C. Edward Dixon, Robert S. B. Clark, John A. Melick, Grant Peters, Raymond P. Griffith

Publikováno v: Brain Research. 951:191-201

Adenosine is an endogenous neuroprotectant via anti-excitotoxic effects at A(1) receptors, and blood flow promoting and anti-inflammatory effects at A(2a) receptors. Previous studies showed improved motor function after fluid percussion injury (FPI)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::510124d85a246a31c48bcff8ecf41301
https://doi.org/10.1016/s0006-8993(02)03161-x

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Regulation of interstitial excitatory amino acid concentrations after cortical contusion injury

Autor: Alan M. Palmer, Joanne K. Schiding, Michele B Huerbin, Steven H. Graham, Marie E. Rose, Donald W. Marion, John A. Melick, Patrick M. Kochanek

Publikováno v: Brain Research. 935:40-46

Increases in brain interstitial excitatory amino acid (EAA(I)) concentrations after ischemia are ameliorated by use-dependent Na+ channel antagonists and by supplementing interstitial glucose, but the regulation of EAA(I) after traumatic brain injury

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::869ff5548b302ef5c0ac3f07812786ab
https://doi.org/10.1016/s0006-8993(02)02445-9

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Caspase-3 Mediated Neuronal Death After Traumatic Brain Injury in Rats

Autor: Robert S. B. Clark, Neal A. Seidberg, Kunlin Jin, Patrick M. Kochanek, Paula D. Nathaniel, Minzhi Chen, Simon C. Watkins, John A. Melick, Steven H. Graham, J. E. Loeffert, C. E. Dixon

Publikováno v: Journal of Neurochemistry. 74:740-753

During programmed cell death, activation of caspase-3 leads to proteolysis of DNA repair proteins, cytoskeletal proteins, and the inhibitor of caspase-activated deoxyribonuclease, culminating in morphologic changes and DNA damage defining apoptosis.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::deed6659bfe42eeca1b1f58cb1f0241e
https://doi.org/10.1046/j.1471-4159.2000.740740.x

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Cerebral perfusion during anesthesia with fentanyl, isoflurane, or pentobarbital in normal rats studied by arterial spin-labeled MRI

Autor: Donald W. Marion, Joanne K. Schiding, Patrick M. Kochanek, Donald S. Williams, Kristy S. Hendrich, Kimberly D. Statler, Chien Ho, John A. Melick

Publikováno v: Magnetic Resonance in Medicine. 46:202-206

The influence of anesthetic agents on cerebral blood flow (CBF) was tested in normal rats. CBF is quantified with arterial spin-labeled MRI in rats anesthetized with either an opiate (fentanyl), a potent inhalation anesthetic agent (isoflurane), or a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef211d6ee44f7c77087fa45d451c4e19
https://doi.org/10.1002/mrm.1178

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Assessment of the effect of 2-chloroadenosine in normal rat brain using spin-labeled MRI measurement of perfusion

Autor: Chien Ho, Edwin K. Jackson, Kristy S. Hendrich, John A. Melick, Patrick M. Kochanek, Donald S. Williams, Donald W. Marion, Courtney L. Robertson

Publikováno v: Magnetic Resonance in Medicine. 45:924-929

Adenosine analogs such as 2-chloroadenosine are potent cerebrovasodilators. Spin-labeled MRI was used to investigate the spatial distribution, dose-response, and timing of the effect of 2-chloroadenosine on cerebral blood flow (CBF) after intraparenc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad47bec04b0e120fa7fe7652baaaa822
https://doi.org/10.1002/mrm.1123

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