Výsledky vyhledávání - "John A. Horton"

Akademický článek

Repurposing epigenetic inhibitors to target the Clostridioides difficile-specific DNA adenine methyltransferase and sporulation regulator CamA

Autor: Jujun Zhou, John R. Horton, Dan Yu, Ren Ren, Robert M. Blumenthal, Xing Zhang, Xiaodong Cheng

Publikováno v: Epigenetics, Vol 17, Iss 9, Pp 970-981 (2022)

Epigenetically targeted therapeutic development, particularly for SAM-dependent methylations of DNA, mRNA and histones has been proceeding rapidly for cancer treatments over the past few years. However, this approach has barely begun to be exploited

Externí odkaz: https://doaj.org/article/5a7bb73e66d04b97acf84d95ef8faf4c

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Akademický článek

Clostridioides difficile specific DNA adenine methyltransferase CamA squeezes and flips adenine out of DNA helix

Autor: Jujun Zhou, John R. Horton, Robert M. Blumenthal, Xing Zhang, Xiaodong Cheng

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)

Clostridioides difficile adenine methyltransferase A (CamA) is required for the sporulation and colonization of the pathogen that causes gastrointestinal infections. Here, the authors characterise CamA kinetically and present its crystal structure bo

Externí odkaz: https://doaj.org/article/72d81f7c9e58495889a373df8da8fa71

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Akademický článek

Metabolic and cardiorespiratory effects of decreasing lung hyperinflation with budesonide/formoterol in COPD: a randomized, double-crossover, placebo-controlled, multicenter trial

Autor: Miguel J. Divo, Michael R. DePietro, John R. Horton, Cherie A. Maguire, Bartolome R. Celli

Publikováno v: Respiratory Research, Vol 21, Iss 1, Pp 1-9 (2020)

Abstract Background Studies suggest that acute decreases in lung hyperinflation at rest improves cardiac function and increases lung vascular perfusion from decompression of a compromised heart. In those studies, changes in resting oxygen uptake indu

Externí odkaz: https://doaj.org/article/01eb242c83bb451aa90eed699ed5e969

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Akademický článek

Structural basis for human ZBTB7A action at the fetal globin promoter

Autor: Yang Yang, Ren Ren, Lana C. Ly, John R. Horton, Fudong Li, Kate G.R. Quinlan, Merlin Crossley, Yunyu Shi, Xiaodong Cheng

Publikováno v: Cell Reports, Vol 36, Iss 13, Pp 109759- (2021)

Summary: Elevated levels of fetal globin protect against β-hemoglobinopathies, such as sickle cell disease and β-thalassemia. Two zinc-finger (ZF) repressors, BCL11A and ZBTB7A/LRF, bind directly to the fetal globin promoter elements positioned at

Externí odkaz: https://doaj.org/article/278a9d06804e4cee8c530abe483c04e3

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Akademický článek

Sociodemographic Predictors of SARS-CoV-2 Infection in Obstetric Patients, Georgia, USA

Autor: Naima T. Joseph, Kaitlyn K. Stanhope, Martina L. Badell, John P. Horton, Sheree L. Boulet, Denise J. Jamieson

Publikováno v: Emerging Infectious Diseases, Vol 26, Iss 11, Pp 2786-2788 (2020)

We conducted a cohort study to determine sociodemographic risk factors for severe acute respiratory syndrome coronavirus 2 infection among obstetric patients in 2 urban hospitals in Atlanta, Georgia, USA. Prevalence of infection was highest among wom

Externí odkaz: https://doaj.org/article/7e23e4c9de3048a88e67677dab8c25fb

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Akademický článek

The cell cycle-regulated DNA adenine methyltransferase CcrM opens a bubble at its DNA recognition site

Autor: John R. Horton, Clayton B. Woodcock, Sifa B. Opot, Norbert O. Reich, Xing Zhang, Xiaodong Cheng

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-9 (2019)

CcrM is a cell cycle-regulated DNA methyltransferase that methylates an adenine within a specific sequence following replication in the gram negative bacterium Caulobacter crescentus. Here the authors present a crystal structure of DNA-bound CcrM tha

Externí odkaz: https://doaj.org/article/4b19d54306f64a6a987f9f163c1d7c87

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Akademický článek

Structural basis for the target specificity of actin histidine methyltransferase SETD3

Autor: Shaobo Dai, John R. Horton, Clayton B. Woodcock, Alex W. Wilkinson, Xing Zhang, Or Gozani, Xiaodong Cheng

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-8 (2019)

SETD3 is the first known metazoan protein histidine methyltransferase but the molecular basis for its target specificity is unclear. Here, the authors elucidate the structural and molecular determinants for the histidine specificity of SETD3.

Externí odkaz: https://doaj.org/article/f2129526184a4597af28ea92c757a4b4

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