Zobrazeno 1 - 10
of 68
pro vyhledávání: '"John A. Butera"'
Autor:
John A. Butera
Publikováno v:
Journal of Medicinal Chemistry. 56:7715-7718
Drug development for neglected tropical diseases, defined as a collection of infectious diseases affecting over 4 billion people worldwide (especially endemic to poverty-stricken populations in underdeveloped regions of Africa, Asia, the Pacific Rim,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0da677823606079b9b75155057bfe067
https://doi.org/10.1021/jm400443k
https://doi.org/10.1021/jm400443k
Autor:
Arlene Joan Dietrich, Warren D. Hirst, Paul Jeffrey Dollings, Afshin Ghavami, Kerri Lipinski, Andrew F. Donnell, John A. Butera
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:2163-2167
Substituted pyridazino[4,5-b]indolizines were identified as potent and selective PDE4B inhibitors. We describe the structure-activity relationships generated around an HTS hit that led to a series of compounds with low nanomolar affinity for PDE4B an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba711653bda7425ea68bc3a2b065dd3c
https://doi.org/10.1016/j.bmcl.2010.02.044
https://doi.org/10.1016/j.bmcl.2010.02.044
Autor:
George P. Vlasuk, James K. Hennan, Gwen A. Morgan, Stephen J. Gardell, Eric I. Rossman, Joel Kantrowitz, Jørgen Petersen, Robert E. Swillo, John A. Butera
Publikováno v:
Journal of Cardiovascular Pharmacology and Therapeutics. 14:207-214
The antiarrhythmic dipeptide, GAP-134, ([2S,4R]-1[2-aminoacetyl]-4-benzamido-pyrrolidine-2-carboxylic acid) was evaluated in canine ischemia/reperfusion model. In dogs subjected to 60-minute ischemia and 4-hour reperfusion, GAP-134 was administered 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49b76e6227e5d070ebcdd5e4ca525079
https://doi.org/10.1177/1074248409340779
https://doi.org/10.1177/1074248409340779
Autor:
John A. Butera, Weiheng Wang, Joan E. Sabalski, Julie Liu, Lynn Resnick, Kevin D. Parris, Jean-Baptiste Telliez, Kerry Combs, Frank Lovering, Steven J. Kirincich
Publikováno v:
Bioorganic & Medicinal Chemistry. 17:3342-3351
A novel series of inhibitors for mitogen activated protein kinase-activated protein kinase 2 (MK-2) are reported. These squarate based inhibitors were identified via a high-throughput screen. An MK2 co-structure with the starting ligand was obtained
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90348df20fa278de0e487146df5bfba2
https://doi.org/10.1016/j.bmc.2009.03.041
https://doi.org/10.1016/j.bmc.2009.03.041
Autor:
Gwen A. Morgan, Kun Liu, James K. Hennan, Eric I. Rossman, Hal S. Feldman, John A. Butera, Julie A. Krueger, Ketil Haugan, Matthew Gruver, Robert E. Swillo, Joel Kantrowitz, Stephen J. Gardell, Jørgen Petersen
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 329:1127-1133
Gap junction uncoupling can alter conduction pathways and promote cardiac re-entry mechanisms that potentiate many supraventricular arrhythmias, such as atrial fibrillation (AF) and atrial flutter (AFL). Our objective was to determine whether GAP-134
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a37f8a52c4329340fe2fa3469579cdda
https://doi.org/10.1124/jpet.108.150102
https://doi.org/10.1124/jpet.108.150102
Autor:
Richard C. Winneker, Thomas J. Berrodin, Nilsa Graciani, Zhiming Zhang, Matthew R. Yudt, Sunil Nagpal, John A. Butera, Scott A. Jelinsky
Publikováno v:
Biochemical Pharmacology. 77:204-215
Progesterone receptor (PR) modulators are used in contraception and post-menopausal hormone therapy, and are under clinical development for reproductive disorders such as uterine fibroids and endometriosis. Development of tissue selective PR modulato
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c00ffa3ecea81b18cac73c23c646fb6
https://doi.org/10.1016/j.bcp.2008.10.016
https://doi.org/10.1016/j.bcp.2008.10.016
Autor:
John A. Butera
Publikováno v:
Journal of Medicinal Chemistry. 50:2543-2546
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a309058aa5ac52f61804d01699819552
https://doi.org/10.1021/jm061015w
https://doi.org/10.1021/jm061015w
Autor:
John Dunlop, John A. Butera
Publikováno v:
Current Topics in Medicinal Chemistry. 6:1897-1906
This review provides an overview of ligands for the excitatory amino acid transporters (EAATs), a family of high-affinity glutamate transporters localized to the plasma membrane of neurons and astroglial cells. Ligand development from the perspective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d1dc47df599872dbdb71dafbe919ca6
https://doi.org/10.2174/156802606778249829
https://doi.org/10.2174/156802606778249829
Autor:
John A. Butera, Thomas M. Argentieri
Publikováno v:
Expert Opinion on Therapeutic Patents. 16:573-585
For over 25 years, the muscarinic receptor antagonists have been the first-line treatment for overactive bladder (OAB). However, severe dry mouth and exacerbation of disease symptoms with prolonged use can result in compliance rates as low as 30%. Ap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0daf423516d71d6b037d653c5c56b37e
https://doi.org/10.1517/13543776.16.5.573
https://doi.org/10.1517/13543776.16.5.573
Autor:
Alexander Greenfield, Tikva Carrick, John A. Butera, Dianne Kowal, John Dunlop, Brian Jow, Cristina Grosanu, Qiang Lu, Beal McIlvain, John P. Williams
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:4985-4988
Excitatory amino acid transporters (EAATs) play a pivotal role in maintaining glutamate homeostasis in the mammalian central nervous system, with the EAAT-2 subtype thought to be responsible for the bulk of the glutamate uptake in forebrain regions.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c5a1dd7bbb3e90347e18220f7cf664f
https://doi.org/10.1016/j.bmcl.2005.08.003
https://doi.org/10.1016/j.bmcl.2005.08.003