Zobrazeno 1 - 10
of 30
pro vyhledávání: '"John A Zuris"'
Autor:
Sagi Tamir, John A Zuris, Lily Agranat, Colin H Lipper, Andrea R Conlan, Dorit Michaeli, Yael Harir, Mark L Paddock, Ron Mittler, Zvi Ioav Cabantchik, Patricia A Jennings, Rachel Nechushtai
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e61202 (2013)
Nutrient-deprivation autophagy factor-1 (NAF-1) (synonyms: Cisd2, Eris, Miner1, and Noxp70) is a [2Fe-2S] cluster protein immune-detected both in endoplasmic reticulum (ER) and mitochondrial outer membrane. It was implicated in human pathology (Wolfr
Externí odkaz:
https://doaj.org/article/784e2a071f1348ef8f98f442fc369770
Autor:
Yong Tao, Veronica Lamas, Wan Du, Wenliang Zhu, Yiran Li, Madelynn N. Whittaker, John A. Zuris, David B. Thompson, Arun Prabhu Rameshbabu, Yilai Shu, Xue Gao, Johnny H. Hu, Charles Pei, Wei-Jia Kong, Xuezhong Liu, Hao Wu, Benjamin P. Kleinstiver, David R. Liu, Zheng-Yi Chen
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Mutations in Atp2b2, an outer hair cell gene, cause dominant hearing loss in humans. Using a mouse model Atp2b2 Obl/+, with a dominant hearing loss mutation (Oblivion), we show that liposome-mediated in vivo delivery of CRISPR-Cas9 ribonucle
Externí odkaz:
https://doaj.org/article/a29936b8a683497cbbd1b953799336a4
Autor:
Alexander G. Allen, Samia Q. Khan, Carrie M. Margulies, Ramya Viswanathan, Swarali Lele, Laura Blaha, Sean N. Scott, Kaitlyn M. Izzo, Alexandra Gerew, Rithu Pattali, Nadire R. Cochran, Carl S. Holland, Amy H. Zhao, Stephen E. Sherman, Michael C. Jaskolka, Meng Wu, Aaron C. Wilson, Xiaoqi Sun, Dawn M. Ciulla, Deric Zhang, Jacqueline D. Nelson, Peisheng Zhang, Patrizia Mazzucato, Yan Huang, Georgia Giannoukos, Eugenio Marco, Michael Nehil, John A. Follit, Kai-Hsin Chang, Mark S. Shearman, Christopher J. Wilson, John A. Zuris
Publikováno v:
Nature Biotechnology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91fd2703df46a1c846f21722568c2f01
https://doi.org/10.1038/s41587-023-01779-8
https://doi.org/10.1038/s41587-023-01779-8
Autor:
Cecilia Cotta-Ramusino, Hayat S Abdulkerim, Eugenio Marco, Frank Buquicchio, Cecilia Fernández, John A. Zuris, Lucas Cohen, Ramya Viswanathan, Kenneth W Gareau, Anne Bothmer, Vic E. Myer
Publikováno v:
The CRISPR Journal. 3:177-187
Multiplexed genome editing with DNA endonucleases has broad application, including for cellular therapies, but chromosomal translocations, natural byproducts of inducing simultaneous genomic breaks, have not been explored in detail. Here we apply var
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::506b5c5ea84f305da86d539021e88dce
https://doi.org/10.1089/crispr.2019.0074
https://doi.org/10.1089/crispr.2019.0074
Autor:
Rithu Pattali, Alexander G Allen, Kaitlyn M Izzo, John A. Zuris, Michael Nehil, Edward Goncz, Kai-Hsin Chang, Kate Zhang, Steven Sexton, Kevin Wasko, Mark S Shearman
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
BackgroundNatural killer (NK) cells have emerged as an alternative cell type for clinical utility given the low propensity for graft-versus-host disease, thereby making NK cells a potential off-the-shelf cell therapy. One critical pathway NK cells us
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da63f513c05c9abaf37d37a779b68ca0
https://doaj.org/article/1b91ac4b5642451dbb1e829e2fb0c879
https://doaj.org/article/1b91ac4b5642451dbb1e829e2fb0c879
Autor:
Nicole M. Bode, Vic E. Myer, Mollie S. Schubert, Liyang Zhang, Jasmine Edelstein, Bernice Thommandru, Steve E. Glenn, Rolf Turk, Richard A. Morgan, Gavin Kurgan, Cecilia Fernández, Matthew S. McNeill, Christopher Borges, Mark A. Behlke, Michael A. Collingwood, Steven Sexton, Swarali Lele, Kevin Wasko, Christopher A. Vakulskas, Sarah F. Beaudoin, Sean N. Scott, John A. Zuris, Ramya Viswanathan, H. Tomas Rube
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79e11b44e1e8a068d9b4628d8d829bb5
https://doi.org/10.1038/s41467-021-24770-w
https://doi.org/10.1038/s41467-021-24770-w
Autor:
Amanda Pfautz, Chris Wilson, Aaron Wilson, Christopher M. Borges, Glenn Leary, Kevin Wasko, William Pierce, Kai-Hsin Chang, Patricia Sousa, Kelly Donahue, Jared Nasser, Steven Sexton, Karrie Wong, John A. Zuris, Owen Porth, Sean P. Scott, Richard A. Morgan, Lincy Prem Antony
Publikováno v:
Regular and young investigator award abstracts.
Background Natural killer (NK) cells distinguish tumor from healthy tissue via multiple mechanisms, including recognition of stress ligands and loss of MHC class I expression. However, effector function of allogeneic NK cells can be diminished by the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::558760d1e0a27dc420cefb76c60fbfde
https://doi.org/10.1136/jitc-2020-sitc2020.0145
https://doi.org/10.1136/jitc-2020-sitc2020.0145
Autor:
Ramya Viswanathan, Rolf Turk, Kevin Wasko, Steve E. Glenn, Michael A. Collingwood, Richard A. Morgan, Swarali Lele, Steven Sexton, Christopher M. Borges, Liyang Zhang, Jasmine Edelstein, Mollie S. Schubert, Sean N. Scott, Sarah F. Beaudoin, Vic E. Myer, Bernice Thommandru, H. Tomas Rube, Nicole M. Bode, John A. Zuris, Matthew S. McNeill, Christopher A. Vakulskas, Cecilia Fernández, Mark A. Behlke, Gavin Kurgan
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Though AsCas12a fills a crucial gap in the current genome editing toolbox, it exhibits relatively poor editing efficiency, restricting its overall utility. Here we isolate an engineered variant, “AsCas12a Ultra”, that increased editing efficiency
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11cb6f438509134b91c7260779016014
https://pubmed.ncbi.nlm.nih.gov/34282150
https://pubmed.ncbi.nlm.nih.gov/34282150
Autor:
Laura C Blaha, John A. Zuris, Alexander G Allen, Kate Zhang, Jared A Getgano, Kevin Wasko, Mark S Shearman, Kaitlyn M Izzo, Rithu Pattali, Kai-Hsin Chang
Publikováno v:
Blood. 138:4809-4809
Current cell and gene therapy medicines for oncology have reshaped how cancer is treated. Specifically, chimeric antigen receptor (CAR)-T cells have demonstrated that cell therapy can achieve durable remissions in hematologic malignancies. However, C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e2fe4e57f1dbbf8f5413a1701a0e8bca
https://doi.org/10.1182/blood-2021-153258
https://doi.org/10.1182/blood-2021-153258
Autor:
Tongyao Wang, John A. Zuris, Charles F Albright, Ramya Viswanathan, E. Brennan, Terence Ta, Sandra Teixeira, Chris Wilson, G. Giannoukos, M. Sanchez, E. de Dreuzy, Patricia Sousa, F. Ta, S. Haskett, D. Tabbaa, Jack Heath, Kai-Hsin Chang, Meltem Isik, J. Siwak, Gregory Gotta, Eugenio Marco
Publikováno v:
HemaSphere. 3:699-700
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::85923a059045d001ee3248d44623ced0
https://doi.org/10.1097/01.hs9.0000564332.87522.af
https://doi.org/10.1097/01.hs9.0000564332.87522.af