Zobrazeno 1 - 10
of 27
pro vyhledávání: '"John A Shupe"'
Autor:
Kateryna Nabukhotna, Shannon L Kordus, John A Shupe, Rubén Cano Rodríguez, Anna Smith, Julia K Bohannon, M Kay Washington, D Borden Lacy
Publikováno v:
PLoS Pathogens, Vol 20, Iss 9, p e1012568 (2024)
Clostridioides difficile is a spore-forming pathogen and the most common cause of healthcare-associated diarrhea and colitis in the United States. Besides producing the main virulence factors, toxin A (TcdA) and toxin B (TcdB), many of the common cli
Externí odkaz:
https://doaj.org/article/e4b4bb5a738b4efeab523e61d2c2ba67
Autor:
Shannon L Kordus, Heather K Kroh, Rubén Cano Rodríguez, Rebecca A Shrem, F Christopher Peritore-Galve, John A Shupe, Brian E Wadzinski, D Borden Lacy, Benjamin W Spiller
Publikováno v:
PLoS Pathogens, Vol 19, Iss 10, p e1011496 (2023)
Clostridioides difficile is a leading cause of antibiotic-associated diarrhea and nosocomial infection in the United States. The symptoms of C. difficile infection (CDI) are associated with the production of two homologous protein toxins, TcdA and Tc
Externí odkaz:
https://doaj.org/article/5c0a09492fa445118a189e4830bc1d37
Autor:
F Christopher Peritore-Galve, John A Shupe, Rory J Cave, Kevin O Childress, M Kay Washington, Sarah A Kuehne, D Borden Lacy
Publikováno v:
PLoS Pathogens, Vol 18, Iss 2, p e1010323 (2022)
Clostridioides difficile infection (CDI) is the leading cause of nosocomial diarrhea and pseudomembranous colitis in the USA. In addition to these symptoms, patients with CDI can develop severe inflammation and tissue damage, resulting in life-threat
Externí odkaz:
https://doaj.org/article/53681cccf54a48f9aac596fac3673cfc
Autor:
Hannah M. Lunnemann, Nicolas G. Shealy, Michelle L. Reyzer, John A. Shupe, Emily H. Green, Uswah Siddiqi, D. Borden Lacy, Mariana X. Byndloss, Nicholas O. Markham
Publikováno v:
Gut Microbes. 15
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bbd381ecab963a04dac4d614fbb10648
https://doi.org/10.1080/19490976.2023.2185029
https://doi.org/10.1080/19490976.2023.2185029
Autor:
F. Christopher Peritore-Galve, Izumi Kaji, Anna Smith, Lauren M. Walker, John A. Shupe, Pradeep K. Dudeja, James R. Goldenring, D. Borden Lacy
Background & AimClostridioides difficileinfection (CDI) is the leading cause of hospital-acquired diarrhea and pseudomembranous colitis. Two protein toxins, TcdA and TcdB, produced byC. difficileare the major determinants of disease. However, the phy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9add9080d8b786eb0788224067387ad
https://doi.org/10.1101/2022.11.12.516162
https://doi.org/10.1101/2022.11.12.516162
Autor:
Dena Lyras, John A. Shupe, Jaime L. Jensen, Michael J Sheedlo, Ashleigh P. Rogers, Sarah C. Bloch, Steven J. Mileto, Melanie L. Hutton, Simon Wilkins, Kevin O. Childress, Genevieve Kerr, D. Borden Lacy, Rebekah Engel, Paul J. McMurrick, Thierry Jarde, Katja Horvay, Tracey J. Flores, Helen E. Abud
Publikováno v:
Proc Natl Acad Sci U S A
Gastrointestinal infections often induce epithelial damage that must be repaired for optimal gut function. While intestinal stem cells are critical for this regeneration process [R. C. van der Wath, B. S. Gardiner, A. W. Burgess, D. W. Smith, PLoS On
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e63a59301301e5ccaa8a9f1761b473d4
https://doi.org/10.1073/pnas.1915255117
https://doi.org/10.1073/pnas.1915255117
Autor:
F. Christopher Peritore-Galve, Audrey K. Thomas, Heather K. Kroh, John A. Shupe, M. Kay Washington, Sarah C. Bloch, Erin N. Laubacher, D. Borden Lacy, Kevin O. Childress, Robert J. Coffey, Nicholas O. Markham
Publikováno v:
Infection and Immunity. 89
Clostridioides difficile is linked to nearly 225,000 antibiotic-associated diarrheal infections and almost 13,000 deaths per year in the United States. Pathogenic strains of C. difficile produce toxin A (TcdA) and toxin B (TcdB), which can directly k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fdd395deb9860a8157017ce04d07c27d
https://doi.org/10.1128/iai.00543-20
https://doi.org/10.1128/iai.00543-20
Autor:
Nicholas O. Markham, Erin N. Laubacher, D. Borden Lacy, John A. Shupe, M. Kay Washington, Sarah C. Bloch, Robert J. Coffey
Clostridioides difficile is linked to nearly 225,000 antibiotic-associated diarrheal infections and almost 13,000 deaths per year in the United States. Pathogenic strains of C. difficile produce toxin A (TcdA) and toxin B (TcdB), which can directly k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::61d0074737b0f94e59a641737f2b3c13
https://doi.org/10.1101/2020.08.30.274738
https://doi.org/10.1101/2020.08.30.274738
Autor:
Nicholas O, Markham, Sarah C, Bloch, John A, Shupe, Erin N, Laubacher, Audrey K, Thomas, Heather K, Kroh, Kevin O, Childress, F Christopher, Peritore-Galve, M Kay, Washington, Robert J, Coffey, D Borden, Lacy
Publikováno v:
Infect Immun
Clostridioides difficile is linked to nearly 225,000 antibiotic-associated diarrheal infections and almost 13,000 deaths per year in the United States. Pathogenic strains of C. difficile produce toxin A (TcdA) and toxin B (TcdB), which can directly k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b8d82289e996b44c13295aade81ef64e
https://pubmed.ncbi.nlm.nih.gov/33468584
https://pubmed.ncbi.nlm.nih.gov/33468584
Autor:
McKenzie King, Melissa A. Farrow, Benjamin W. Spiller, John A. Shupe, Sarah C. Bloch, Kaycei Moton-Melancon, Nicole M. Chumber, D. Borden Lacy, Mary Kay Washington
Publikováno v:
ACS Chem Biol
Clostridioides difficile is the leading cause of nosocomial diarrhea in the United States. The primary virulence factors are two homologous sglucosyltransferase toxins, TcdA and TcdB, that inactivate host Rho-family GTPases. The glucosyltransferase a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc73c87bf52e2809cf36861a6dc889f9
https://europepmc.org/articles/PMC7230009/
https://europepmc.org/articles/PMC7230009/