Zobrazeno 1 - 10
of 719
pro vyhledávání: '"John A Katzenellenbogen"'
Autor:
Jerome C Nwachukwu, Sathish Srinivasan, Yangfan Zheng, Song Wang, Jian Min, Chune Dong, Zongquan Liao, Jason Nowak, Nicholas J Wright, René Houtman, Kathryn E Carlson, Jatinder S Josan, Olivier Elemento, John A Katzenellenbogen, Hai‐Bing Zhou, Kendall W Nettles
Publikováno v:
Molecular Systems Biology, Vol 12, Iss 4, Pp 1-14 (2016)
Abstract Some estrogen receptor‐α (ERα)‐targeted breast cancer therapies such as tamoxifen have tissue‐selective or cell‐specific activities, while others have similar activities in different cell types. To identify biophysical determinants
Externí odkaz:
https://doaj.org/article/cf1c1a8640554626b04f8b7d235ebf06
Autor:
Sean W Fanning, Rinath Jeselsohn, Venkatasubramanian Dharmarajan, Christopher G Mayne, Mostafa Karimi, Gilles Buchwalter, René Houtman, Weiyi Toy, Colin E Fowler, Ross Han, Muriel Lainé, Kathryn E Carlson, Teresa A Martin, Jason Nowak, Jerome C Nwachukwu, David J Hosfield, Sarat Chandarlapaty, Emad Tajkhorshid, Kendall W Nettles, Patrick R Griffin, Yang Shen, John A Katzenellenbogen, Myles Brown, Geoffrey L Greene
Publikováno v:
eLife, Vol 7 (2018)
Acquired resistance to endocrine therapy remains a significant clinical burden for breast cancer patients. Somatic mutations in the ESR1 (estrogen receptor alpha (ERα)) gene ligand-binding domain (LBD) represent a recognized mechanism of acquired re
Externí odkaz:
https://doaj.org/article/582b84ec644248bbb6fb9af5a9be5532
Autor:
Zeynep Madak‐Erdogan, Tze‐Howe Charn, Yan Jiang, Edison T Liu, John A Katzenellenbogen, Benita S Katzenellenbogen
Publikováno v:
Molecular Systems Biology, Vol 13, Iss 4, Pp n/a-n/a (2017)
Externí odkaz:
https://doaj.org/article/509dfa82225f4dbd8fe642cd5e6c7edb
Autor:
Anne Abot, Coralie Fontaine, Mélissa Buscato, Romain Solinhac, Gilles Flouriot, Aurélie Fabre, Anne Drougard, Shyamala Rajan, Muriel Laine, Alain Milon, Isabelle Muller, Daniel Henrion, Marine Adlanmerini, Marie‐Cécile Valéra, Anne Gompel, Céline Gerard, Christel Péqueux, Mélanie Mestdagt, Isabelle Raymond‐Letron, Claude Knauf, François Ferriere, Philippe Valet, Pierre Gourdy, Benita S Katzenellenbogen, John A Katzenellenbogen, Françoise Lenfant, Geoffrey L Greene, Jean‐Michel Foidart, Jean‐François Arnal
Publikováno v:
EMBO Molecular Medicine, Vol 6, Iss 10, Pp 1328-1346 (2014)
Abstract Estetrol (E4) is a natural estrogen with a long half‐life produced only by the human fetal liver during pregnancy. The crystal structures of the estrogen receptor α (ERα) ligand‐binding domain bound to 17β‐estradiol (E2) and E4 are
Externí odkaz:
https://doaj.org/article/f81d485b302d454596333e69beb5f6bc
Autor:
Zeynep Madak‐Erdogan, Tze‐Howe Charn, Yan Jiang, Edison T Liu, John A Katzenellenbogen, Benita S Katzenellenbogen
Publikováno v:
Molecular Systems Biology, Vol 9, Iss 1, Pp 1-19 (2013)
Abstract The closely related transcription factors (TFs), estrogen receptors ERα and ERβ, regulate divergent gene expression programs and proliferative outcomes in breast cancer. Utilizing breast cancer cells with ERα, ERβ, or both receptors as a
Externí odkaz:
https://doaj.org/article/f68048a262e64fbc98d5940ec13e2b2a
Autor:
Sean W Fanning, Christopher G Mayne, Venkatasubramanian Dharmarajan, Kathryn E Carlson, Teresa A Martin, Scott J Novick, Weiyi Toy, Bradley Green, Srinivas Panchamukhi, Benita S Katzenellenbogen, Emad Tajkhorshid, Patrick R Griffin, Yang Shen, Sarat Chandarlapaty, John A Katzenellenbogen, Geoffrey L Greene
Publikováno v:
eLife, Vol 5 (2016)
Somatic mutations in the estrogen receptor alpha (ERα) gene (ESR1), especially Y537S and D538G, have been linked to acquired resistance to endocrine therapies. Cell-based studies demonstrated that these mutants confer ERα constitutive activity and
Externí odkaz:
https://doaj.org/article/d72eb07c0ab74842a4752908808171ae
Autor:
Jerome C Nwachukwu, Sathish Srinivasan, Nelson E Bruno, Alexander A Parent, Travis S Hughes, Julie A Pollock, Olsi Gjyshi, Valerie Cavett, Jason Nowak, Ruben D Garcia-Ordonez, René Houtman, Patrick R Griffin, Douglas J Kojetin, John A Katzenellenbogen, Michael D Conkright, Kendall W Nettles
Publikováno v:
eLife, Vol 3 (2014)
Resveratrol has beneficial effects on aging, inflammation and metabolism, which are thought to result from activation of the lysine deacetylase, sirtuin 1 (SIRT1), the cAMP pathway, or AMP-activated protein kinase. In this study, we report that resve
Externí odkaz:
https://doaj.org/article/fb4d849c2f4b408cb4639c209bbfccd2
Publikováno v:
eLife, Vol 2 (2013)
By using in silico models of the complexes formed by analogues of a cancer drug and its receptor, it may be possible to strategically redesign existing drugs and win the race against mutations that lead to drug resistance in prostate cancer.
Externí odkaz:
https://doaj.org/article/2eb58a7ead8e4f09960addaa0434ed9d
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e78593 (2013)
Male cystic fibrosis (CF) patients survive longer than females and lung exacerbations in CF females vary during the estrous cycle. Estrogen has been reported to reduce the height of the airway surface liquid (ASL) in female CF bronchial epithelium. H
Externí odkaz:
https://doaj.org/article/59a51afd9937404f8c69d324b9753e06
Autor:
Farrokh Dehdashti, Ningying Wu, Cynthia X. Ma, Michael J. Naughton, John A. Katzenellenbogen, Barry A. Siegel
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Clinical estrogen receptor (ER) testing for breast cancer is limited in predicting response to endocrine therapy (ET). In this phase 2 clinical trial, authors demonstrate that the responsiveness to ET can be predicted by use of PET/CT with 21-[18F]fl
Externí odkaz:
https://doaj.org/article/ff6d3e01875a44a08508cf739b64d668