Zobrazeno 1 - 10
of 657
pro vyhledávání: '"John A Hardy"'
Autor:
Christina M Lill, Johannes T Roehr, Matthew B McQueen, Fotini K Kavvoura, Sachin Bagade, Brit-Maren M Schjeide, Leif M Schjeide, Esther Meissner, Ute Zauft, Nicole C Allen, Tian Liu, Marcel Schilling, Kari J Anderson, Gary Beecham, Daniela Berg, Joanna M Biernacka, Alexis Brice, Anita L DeStefano, Chuong B Do, Nicholas Eriksson, Stewart A Factor, Matthew J Farrer, Tatiana Foroud, Thomas Gasser, Taye Hamza, John A Hardy, Peter Heutink, Erin M Hill-Burns, Christine Klein, Jeanne C Latourelle, Demetrius M Maraganore, Eden R Martin, Maria Martinez, Richard H Myers, Michael A Nalls, Nathan Pankratz, Haydeh Payami, Wataru Satake, William K Scott, Manu Sharma, Andrew B Singleton, Kari Stefansson, Tatsushi Toda, Joyce Y Tung, Jeffery Vance, Nick W Wood, Cyrus P Zabetian, andMe Genetic Epidemiology of Parkinson's Disease Consortium, International Parkinson's Disease Genomics Consortium, Parkinson's Disease GWAS Consortium, Wellcome Trust Case Control Consortium 2), Peter Young, Rudolph E Tanzi, Muin J Khoury, Frauke Zipp, Hans Lehrach, John P A Ioannidis, Lars Bertram
Publikováno v:
PLoS Genetics, Vol 8, Iss 3, p e1002548 (2012)
More than 800 published genetic association studies have implicated dozens of potential risk loci in Parkinson's disease (PD). To facilitate the interpretation of these findings, we have created a dedicated online resource, PDGene, that comprehensive
Externí odkaz:
https://doaj.org/article/cfc8c07e05884d89b6a183d737c73b81
Autor:
Dena G Hernandez, Michael A Nalls, Pauli Ylikotila, Margaux Keller, John A Hardy, Kari Majamaa, Andrew B Singleton
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e41859 (2012)
In the current study we undertook a series of experiments to test the hypothesis that a monogenic cause of disease may be detectable within a cohort of Finnish young onset Parkinson's disease patients. In the first instance we performed standard geno
Externí odkaz:
https://doaj.org/article/618bb2396c2843a48fefd23cf5e09f24
Autor:
Tohru Matsuki, Mariam Zaka, Rita Guerreiro, Marcel P van der Brug, Jonathan A Cooper, Mark R Cookson, John A Hardy, Brian W Howell
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e31152 (2012)
Hyperphosphorylation of the microtubule binding protein Tau is a feature of a number of neurodegenerative diseases, including Alzheimer's disease. Tau is hyperphosphorylated in the hippocampus of dab1-null mice in a strain-dependent manner; however,
Externí odkaz:
https://doaj.org/article/14392d838ecd4c46a795ebe425d58d59
Autor:
Manoj B. Sharma, Hend A. M. Abdelmohsen, Özlem Kap, Volkan Kilic, Nesrin Horzum, David Cheneler, John G. Hardy
Publikováno v:
Bioengineering, Vol 11, Iss 7, p 649 (2024)
Microneedle arrays are minimally invasive devices that have been extensively investigated for the transdermal/intradermal delivery of drugs/bioactives. Here, we demonstrate the release of bioactive molecules (estradiol, melatonin and meropenem) from
Externí odkaz:
https://doaj.org/article/ed9186ddd64e468eb440cd89c321d1e8
Autor:
Melike Firlak Demirkan, John G. Hardy
Publikováno v:
Gels, Vol 10, Iss 5, p 310 (2024)
A gel can be defined as a semi-solid structure that has mechanical properties ranging from tough to soft, depending on their constituents [...]
Externí odkaz:
https://doaj.org/article/9f9e333389e442878e7c9179c229913e
Autor:
Zijian Zhang, Xingyu Yang, Zhiyi Zhao, Feng Zeng, Sicong Ye, Sara J. Baldock, Hungyen Lin, John G. Hardy, Yalin Zheng, Yaochun Shen
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Fourier domain optical coherence tomography (FD-OCT) is a well-established imaging technique that provides high-resolution internal structure images of an object at a fast speed. Modern FD-OCT systems typically operate at speeds of 40,000–
Externí odkaz:
https://doaj.org/article/4c1fa1be53c44c61a59bfddefa62c73f
Autor:
Manoj B. Sharma, Özlem Kap, Hend A. M. Abdelmohsen, Mark D. Ashton, Garry R. Harper, Melike Firlak, Jasmine E. Aaltonen, Kerry A. Bolland, Ryan Bragg, Sarah Deeley, Ella Francis, Nahin Kazi, Bethany L. Mapley, Vasileios Oikonomou, Amal D. Aljohani, David Cheneler, Volkan Kilic, Nesrin Horzum, John G. Hardy
Publikováno v:
Global Challenges, Vol 7, Iss 8, Pp n/a-n/a (2023)
Abstract The release of metformin, a drug used in the treatment of cancer and diabetes, from poly(2‐hydroxyethyl methacrylate), pHEMA, hydrogel‐based microneedle patches is demonstrated in vitro. Tuning the composition of the pHEMA hydrogels enab
Externí odkaz:
https://doaj.org/article/d1643f58885a40e4b029c400a9c62c7b
Autor:
Mathew J. Haskew, Shahin Nikman, Carys E. O'Sullivan, Hanaa A. Galeb, Nathan R. Halcovitch, John G. Hardy, Samuel T. Murphy
Publikováno v:
Nano Select, Vol 4, Iss 1, Pp 90-101 (2023)
Abstract Batteries are utilized in a multitude of devices encountered in our daily lives. Here we describe a comparative study of Magnesium‐air and Zinc‐air primary batteries using silk fibroin‐ionic liquid polymer electrolytes (composed of Bom
Externí odkaz:
https://doaj.org/article/c176caf4a30c4e888902ed45c5ea87ed
Autor:
Yang Li, Ningyi Dai, Wilfried G. J. H. M. Van Sark, Mohammadreza Aghaei, Giovanni Malara, João C. C. Henriques, Zhengshun Cheng, Andreas Borgschulte, Rahul R. Bhosale, Pejman Kazempoor, Prodip K. Das, John S. Hardy
Publikováno v:
Frontiers in Energy Research, Vol 11 (2023)
Externí odkaz:
https://doaj.org/article/0190e75f630040289cdfd7a5648a53f7
Autor:
Zhongbo Chen, Regina H. Reynolds, Antonio F. Pardiñas, Sarah A. Gagliano Taliun, Wouter van Rheenen, Kuang Lin, Aleksey Shatunov, Emil K. Gustavsson, Isabella Fogh, Ashley R. Jones, Wim Robberecht, Philippe Corcia, Adriano Chiò, Pamela J. Shaw, Karen E. Morrison, Jan H. Veldink, Leonard H. van den Berg, Christopher E. Shaw, John F. Powell, Vincenzo Silani, John A. Hardy, Henry Houlden, Michael J. Owen, Martin R. Turner, Mina Ryten, Ammar Al-Chalabi
Publikováno v:
Neurobiology of Disease, Vol 180, Iss , Pp 106082- (2023)
Humans are thought to be more susceptible to neurodegeneration than equivalently-aged primates. It is not known whether this vulnerability is specific to anatomically-modern humans or shared with other hominids. The contribution of introgressed Neand
Externí odkaz:
https://doaj.org/article/f01fd2a5dcf3454199658ca3a44ca0e9