Zobrazeno 1 - 10
of 178
pro vyhledávání: '"John A G Briggs"'
Autor:
Kun Qu, Qiuluan Chen, Katarzyna A Ciazynska, Banghui Liu, Xixi Zhang, Jingjing Wang, Yujie He, Jiali Guan, Jun He, Tian Liu, Xiaofei Zhang, Andrew P Carter, Xiaoli Xiong, John A G Briggs
Publikováno v:
PLoS Pathogens, Vol 18, Iss 7, p e1010583 (2022)
The spike (S) protein of SARS-CoV-2 has been observed in three distinct pre-fusion conformations: locked, closed and open. Of these, the function of the locked conformation remains poorly understood. Here we engineered a SARS-CoV-2 S protein construc
Externí odkaz:
https://doaj.org/article/83d352c1856c449ebb657a1e1f0de933
Autor:
Robert A Dick, Chaoyi Xu, Dustin R Morado, Vladyslav Kravchuk, Clifton L Ricana, Terri D Lyddon, Arianna M Broad, J Ryan Feathers, Marc C Johnson, Volker M Vogt, Juan R Perilla, John A G Briggs, Florian K M Schur
Publikováno v:
PLoS Pathogens, Vol 16, Iss 1, p e1008277 (2020)
Retrovirus assembly is driven by the multidomain structural protein Gag. Interactions between the capsid domains (CA) of Gag result in Gag multimerization, leading to an immature virus particle that is formed by a protein lattice based on dimeric, tr
Externí odkaz:
https://doaj.org/article/c3daa523b8f640e092a5ea59c68b3690
Autor:
Svetlana O Dodonova, Patrick Aderhold, Juergen Kopp, Iva Ganeva, Simone Röhling, Wim J H Hagen, Irmgard Sinning, Felix Wieland, John A G Briggs
Publikováno v:
eLife, Vol 6 (2017)
COPI coated vesicles mediate trafficking within the Golgi apparatus and between the Golgi and the endoplasmic reticulum. Assembly of a COPI coated vesicle is initiated by the small GTPase Arf1 that recruits the coatomer complex to the membrane, trigg
Externí odkaz:
https://doaj.org/article/300fbb86222a4c5989cb1a9db6e217d6
Autor:
Norman E Davey, Venkata P Satagopam, Salvador Santiago-Mozos, Carlos Villacorta-Martin, Tanmay A M Bharat, Reinhard Schneider, John A G Briggs
Publikováno v:
PLoS Computational Biology, Vol 10, Iss 12, p e1003951 (2014)
Huge research effort has been invested over many years to determine the phenotypes of natural or artificial mutations in HIV proteins--interpretation of mutation phenotypes is an invaluable source of new knowledge. The results of this research effort
Externí odkaz:
https://doaj.org/article/8e6f4c69bb7b49c3853f2bd2bcbebf3c
Autor:
Olga V Kalinina, Heike Oberwinkler, Bärbel Glass, Hans-Georg Kräusslich, Robert B Russell, John A G Briggs
Publikováno v:
PLoS ONE, Vol 7, Iss 8, p e42468 (2012)
Pairs of amino acid positions that evolve in a correlated manner are proposed to play important roles in protein structure or function. Methods to detect them might fare better with families for which sequences of thousands of closely related homolog
Externí odkaz:
https://doaj.org/article/3a17c9e7135941059278310cb8d8ed19
Autor:
Tanmay A M Bharat, James D Riches, Larissa Kolesnikova, Sonja Welsch, Verena Krähling, Norman Davey, Marie-Laure Parsy, Stephan Becker, John A G Briggs
Publikováno v:
PLoS Biology, Vol 9, Iss 11, p e1001196 (2011)
Several major human pathogens, including the filoviruses, paramyxoviruses, and rhabdoviruses, package their single-stranded RNA genomes within helical nucleocapsids, which bud through the plasma membrane of the infected cell to release enveloped viri
Externí odkaz:
https://doaj.org/article/add284b5168b49b7a8f0d8b2547f688e
Autor:
Lars-Anders Carlson, Alex de Marco, Heike Oberwinkler, Anja Habermann, John A G Briggs, Hans-Georg Kräusslich, Kay Grünewald
Publikováno v:
PLoS Pathogens, Vol 6, Iss 11, p e1001173 (2010)
The structure of immature and mature HIV-1 particles has been analyzed in detail by cryo electron microscopy, while no such studies have been reported for cellular HIV-1 budding sites. Here, we established a system for studying HIV-1 virus-like parti
Externí odkaz:
https://doaj.org/article/d219a1f0cc2b4be1b985f3a3ab4fadc8
Autor:
Sonja Welsch, Larissa Kolesnikova, Verena Krähling, James D Riches, Stephan Becker, John A G Briggs
Publikováno v:
PLoS Pathogens, Vol 6, Iss 4, p e1000875 (2010)
The filoviruses, Marburg and Ebola, are non-segmented negative-strand RNA viruses causing severe hemorrhagic fever with high mortality rates in humans and nonhuman primates. The sequence of events that leads to release of filovirus particles from cel
Externí odkaz:
https://doaj.org/article/23365fcaa7544805b42cefc54604f872
Autor:
Alex de Marco, Barbara Müller, Bärbel Glass, James D Riches, Hans-Georg Kräusslich, John A G Briggs
Publikováno v:
PLoS Pathogens, Vol 6, Iss 11, p e1001215 (2010)
HIV-1 buds form infected cells in an immature, non-infectious form. Maturation into an infectious virion requires proteolytic cleavage of the Gag polyprotein at five positions, leading to a dramatic change in virus morphology. Immature virions contai
Externí odkaz:
https://doaj.org/article/b5a943b2d9344927b2952f8ee432dba0
Autor:
Gur Fabrikant, Suman Lata, James D Riches, John A G Briggs, Winfried Weissenhorn, Michael M Kozlov
Publikováno v:
PLoS Computational Biology, Vol 5, Iss 11, p e1000575 (2009)
ESCRT-III proteins catalyze membrane fission during multi vesicular body biogenesis, budding of some enveloped viruses and cell division. We suggest and analyze a novel mechanism of membrane fission by the mammalian ESCRT-III subunits CHMP2 and CHMP3
Externí odkaz:
https://doaj.org/article/c9321f3bfc2b4dcf889f87856cc7d8fe