Zobrazeno 1 - 10
of 871
pro vyhledávání: '"John A Cole"'
Autor:
Sabha Asghar, Gary J. Litherland, John J. Cole, Iain B. McInnes, R. M. D. Meek, John C. Lockhart, Carl S. Goodyear, Anne Crilly
Publikováno v:
Arthritis Research & Therapy, Vol 26, Iss 1, Pp 1-14 (2024)
Abstract Background Small extracellular vesicles (sEV) derived from synovial fibroblasts (SF) represent a novel molecular mechanism regulating cartilage erosion in osteoarthritis (OA). However, a comprehensive evaluation using disease relevant cells
Externí odkaz:
https://doaj.org/article/3b5cf59e34534e7c8772f11be34ab22f
Publikováno v:
PLoS Computational Biology, Vol 13, Iss 9, p e1005728 (2017)
Using protein counts sampled from single cell proteomics distributions to constrain fluxes through a genome-scale model of metabolism, Population flux balance analysis (Population FBA) successfully described metabolic heterogeneity in a population of
Externí odkaz:
https://doaj.org/article/a3100f5f93ab4681b7209bebddf0826c
Publikováno v:
PLoS ONE, Vol 12, Iss 8, p e0182570 (2017)
Characterizing the complex spatial and temporal interactions among cells in a biological system (i.e. bacterial colony, microbiome, tissue, etc.) remains a challenge. Metabolic cooperativity in these systems can arise due to the subtle interplay betw
Externí odkaz:
https://doaj.org/article/748ae232ed1a4c7cb468800bece1250d
Publikováno v:
PLoS ONE, Vol 12, Iss 12, p e0190193 (2017)
[This corrects the article DOI: 10.1371/journal.pone.0182570.].
Externí odkaz:
https://doaj.org/article/0f75f4b1639b4e569eaa48b4b8e5952d
Publikováno v:
International Journal of Translational Medicine, Vol 4, Iss 2, Pp 354-368 (2024)
Tyrosine kinase inhibitors (TKIs), such as imatinib (IM), increase the survival of chronic myeloid leukemia (CML) patients but do not eradicate the disease as leukemia stem cells (LSCs) with primitive and quiescent signatures persist after TKI monoth
Externí odkaz:
https://doaj.org/article/7634c85c657d4850b5341db0698fea94
Autor:
Patrícia Iana Schmidt, Lucio Flavio Macedo Mota, Larissa Fernanda Simielli Fonseca, Danielly Beraldo dos Santos Silva, Gabriela Bonfá Frezarim, Leonardo Machestropa Arikawa, Daniel Jordan de Abreu Santos, Ana Fabrícia Braga Magalhães, John Bruce Cole, Roberto Carvalheiro, Henrique Nunes de Oliveira, Daniel Jacob Null, Paul VanRaden, Li Ma, Lucia Galvão de Albuquerque
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract The wide use of genomic information has enabled the identification of lethal recessive alleles that are the major genetic causes of reduced conception rates, longer calving intervals, or lower survival for live-born animals. This study was c
Externí odkaz:
https://doaj.org/article/cabc2a3fbfc74a25b22dd10b24eec218
Autor:
Joseph R. Peterson, John A. Cole, John R. Pfeiffer, Gregory H. Norris, Yuhan Zhang, Dorys Lopez-Ramos, Tushar Pandey, Matthew Biancalana, Hope R. Esslinger, Anuja K. Antony, Vinita Takiar
Publikováno v:
Breast Cancer Research, Vol 25, Iss 1, Pp 1-13 (2023)
Abstract Background Generalizable population-based studies are unable to account for individual tumor heterogeneity that contributes to variability in a patient’s response to physician-chosen therapy. Although molecular characterization of tumors h
Externí odkaz:
https://doaj.org/article/12eef036e02a49309bc1c05dd6fdb0b4
Genomic risk scores and oral contraceptive-associated ischemic stroke risk: a call for collaboration
Autor:
Forrest Lin, Liisa Tomppo, Brady Gaynor, Kathleen Ryan, John W. Cole, Braxton D. Mitchell, Jukka Putaala, Steven J. Kittner
Publikováno v:
Frontiers in Stroke, Vol 2 (2023)
BackgroundOral contraceptives (OCs) are generally safe but vascular risk factors increase OC-associated ischemic stroke risk. We performed a case-control study to evaluate whether a genomic risk score for ischemic stroke modifies OC-associated ischem
Externí odkaz:
https://doaj.org/article/120b4fc8cffc4087aaa5fcaf4b605f2f
Autor:
Jia-Lu Qiao, Rebecca T. Levinson, Bowang Chen, Stefan T. Engelter, Philipp Erhart, Brady J. Gaynor, Patrick F. McArdle, Kristina Schlicht, Michael Krawczak, Martin Stenman, Arne G. Lindgren, John W. Cole, Caspar Grond-Ginsbach
Publikováno v:
Frontiers in Genetics, Vol 14 (2023)
Objective: Most methods to detect copy number variation (CNV) have high false positive rates, especially for small CNVs and in real-life samples from clinical studies. In this study, we explored a novel scatterplot-based method to detect CNVs in micr
Externí odkaz:
https://doaj.org/article/7be1580509cb41f88911f69fde5cde78
Autor:
Yuelin Yao, Shuli Liu, Charley Xia, Yahui Gao, Zhangyuan Pan, Oriol Canela-Xandri, Ava Khamseh, Konrad Rawlik, Sheng Wang, Bingjie Li, Yi Zhang, Erola Pairo-Castineira, Kenton D’Mellow, Xiujin Li, Ze Yan, Cong-jun Li, Ying Yu, Shengli Zhang, Li Ma, John B. Cole, Pablo J. Ross, Huaijun Zhou, Chris Haley, George E. Liu, Lingzhao Fang, Albert Tenesa
Publikováno v:
Genome Biology, Vol 23, Iss 1, Pp 1-24 (2022)
Abstract Background Cross-species comparison of transcriptomes is important for elucidating evolutionary molecular mechanisms underpinning phenotypic variation between and within species, yet to date it has been essentially limited to model organisms
Externí odkaz:
https://doaj.org/article/8e63f5a62bc44afea9ce80f059475d95