Zobrazeno 1 - 10
of 222
pro vyhledávání: '"John A Chiorini"'
Autor:
Hiroyuki Nakamura, Tsutomu Tanaka, Youngmi Ji, Changyu Zheng, Sandra A Afione, Blake M Warner, Fabiola Reis Oliveira, Ana Carolina F Motta, Eduardo M Rocha, Masayuki Noguchi, Tatsuya Atsumi, John A Chiorini
Publikováno v:
PLoS ONE, Vol 18, Iss 2, p e0282227 (2023)
Hydroxychloroquine (HCQ) is a lysosomotropic agent that is commonly used for treating Sjögren's disease (SjD). However, its efficacy is controversial because of the divergent response to the drug among patients. In a subgroup of SjD patients, lysoso
Externí odkaz:
https://doaj.org/article/acc41cde337d44419ebc591577fb4021
Autor:
Lu Gan, Terrance P O'Hanlon, Zhennan Lai, Rick Fannin, Melodie L Weller, Lisa G Rider, John A Chiorini, Frederick W Miller
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0142486 (2015)
Viral agents are of interest as possible autoimmune triggers due to prior reported associations and widely studied molecular mechanisms of antiviral immune responses in autoimmunity. Here we examined new viral candidates for the initiation and/or pro
Externí odkaz:
https://doaj.org/article/79b7ab5bcff242bc863a4182af177aa4
Autor:
Hongen Yin, Peter Kosa, Xibao Liu, William D Swaim, Zhennan Lai, Javier Cabrera-Perez, Giovanni Di Pasquale, Indu S Ambudkar, Thomas H Bugge, John A Chiorini
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e82852 (2014)
The objective of this study was to determine the effect of epithelial barrier disruption, caused by deficiency of the membrane-anchored serine protease, matriptase, on salivary gland function and the induction of autoimmunity in an animal model.Embry
Externí odkaz:
https://doaj.org/article/7da495799aa74d65b071f95ac9772e76
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e92832 (2014)
In preparation for testing the safety of using serotype 2 recombinant adeno-associated vector, encoding Aquaporin-1 to treat radiation-induced salivary gland damage in a phase 1 clinical trial, we conducted a 13 week GLP biodistribution and toxicolog
Externí odkaz:
https://doaj.org/article/570388e5bbaa40e0a7342973957c7332
Autor:
Giovanni Di Pasquale, Ilaria Dicembrini, Laura Raimondi, Claudio Pagano, Josephine M Egan, Andrea Cozzi, Lorenzo Cinci, Andrea Loreto, Maria E Manni, Silvia Berretti, Annamaria Morelli, Changyu Zheng, Drew G Michael, Mario Maggi, Roberto Vettor, John A Chiorini, Edoardo Mannucci, Carlo M Rotella
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e40074 (2012)
Exendin-4 (Ex-4) is a Glucagon-like peptide 1 (GLP-1) receptor agonist approved for the treatment of Type 2 Diabetes (T2DM), which requires daily subcutaneous administration. In T2DM patients, GLP-1 administration is reported to reduce glycaemia and
Externí odkaz:
https://doaj.org/article/b5a58b6ba4de46ae91ab1ee5fd254e6b
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e51375 (2012)
CD40-CD154 (CD40 ligand) interaction in the co-stimulatory pathway is involved in many (auto)immune processes and both molecules are upregulated in salivary glands of Sjögren's syndrome (SS) patients. Interference within the CD40 pathway has amelior
Externí odkaz:
https://doaj.org/article/af38082c2d02445080fe10e5c6f1312e
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e19962 (2011)
Intercellular adhesion molecule-1 (ICAM-1) is involved in migration and co-stimulation of T and B cells. Membrane bound ICAM-1 is over expressed in the salivary glands (SG) of Sjögren's syndrome (SS) patients and has therefore been proposed as a pot
Externí odkaz:
https://doaj.org/article/e7e94273db88427781e2ce01653f7fed
Autor:
Giulia Crispino, Giovanni Di Pasquale, Pietro Scimemi, Laura Rodriguez, Fabian Galindo Ramirez, Romolo Daniele De Siati, Rosa Maria Santarelli, Edoardo Arslan, Mario Bortolozzi, John A Chiorini, Fabio Mammano
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e23279 (2011)
The deafness locus DFNB1 contains GJB2, the gene encoding connexin26 and GJB6, encoding connexin30, which appear to be coordinately regulated in the inner ear. In this work, we investigated the expression and function of connexin26 and connexin30 fro
Externí odkaz:
https://doaj.org/article/f7d65068302f431e8428757bfc8a5321
Autor:
Hongen Yin, Jelle L Vosters, Nienke Roescher, Anil D'Souza, Biji T Kurien, Paul P Tak, John A Chiorini
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e18003 (2011)
INTRODUCTION: Anti-Ro antibodies can be found in the serum of the majority of patients with Sjögren's syndrome (SS). Immunization with a 60-kDa Ro peptide has been shown to induce SS-like symptoms in mice. The aim of this study was to investigate fa
Externí odkaz:
https://doaj.org/article/69ba32f632aa41c49dcee4295d2d2816
Publikováno v:
PLoS ONE, Vol 5, Iss 3, p e9336 (2010)
Cell surface carbohydrates play an important role in virus entry and intracellular trafficking. Bovine Adeno-Associated Virus (BAAV) uses plasma membrane gangliosides for transduction and infection. In addition, independent of the infectious pathway,
Externí odkaz:
https://doaj.org/article/88ff38271da2466cbae6d5afce26a383