Zobrazeno 1 - 10
of 352
pro vyhledávání: '"John A Chiorini"'
Autor:
Peter D. Burbelo, Julio A. Huapaya, Zohreh Khavandgar, Margaret Beach, Iago Pinal-Fernandez, Andrew L. Mammen, John A. Chiorini, Payam Noroozi Farhadi, Frederick W. Miller, Adam Schiffenbauer, Kakali Sarkar, Blake M. Warner, Lisa G. Rider
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Autoantibodies are important for the diagnosis of autoimmune interstitial lung disease (ILD). Standard immunoassays have limitations, including their qualitative nature and/or a narrow dynamic range of detection, hindering the usefulness of autoantib
Externí odkaz:
https://doaj.org/article/64b96c4ac6b14506921ee64e276ed00b
Autor:
Randy J. Chandler, Giovanni Di Pasquale, Eun-Young Choi, David Chang, Stephanie N. Smith, Jennifer L. Sloan, Victoria Hoffmann, Lina Li, John A. Chiorini, Charles P. Venditti
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 30, Iss , Pp 181-190 (2023)
Propionic acidemia (PA) is rare autosomal recessive metabolic disorder caused by defects in the mitochondrially localized enzyme propionyl-coenzyme A (CoA) carboxylase. Patients with PA can suffer from lethal metabolic decompensation and cardiomyopat
Externí odkaz:
https://doaj.org/article/c35059820a4742ec9fa25d51c2cda8e8
Autor:
Tsutomu Tanaka, Hiroyuki Nakamura, Duy T. Tran, Blake M. Warner, Yan Wang, Tatsuya Atsumi, Masayuki Noguchi, John A. Chiorini
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)
Abstract Sjögren’s disease (SjD) is an autoimmune disease that affects exocrine tissues and is characterized by increased apoptosis in salivary and lacrimal glands. Although the pathogenic mechanism triggering SjD is not well understood, overexpre
Externí odkaz:
https://doaj.org/article/4676d71c001746da9d933237cc8fe2bb
Autor:
Randy J. Chandler, Giovanni Di Pasquale, Jennifer L. Sloan, Samantha McCoy, Brandon T. Hubbard, Tina M. Kilts, Irini Manoli, John A. Chiorini, Charles P. Venditti
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 27, Iss , Pp 61-72 (2022)
Methylmalonic acidemia (MMA) is a severe and potentially lethal autosomal recessive inborn error of metabolism most frequently caused by mutations in the methylmalonyl-CoA mutase (MMUT) gene. Proof-of-concept adeno-associated virus (AAV) gene therapy
Externí odkaz:
https://doaj.org/article/5caff188f5664f588fdfedae48923440
Autor:
Hiroyuki Nakamura, Tsutomu Tanaka, Changyu Zheng, Sandra A. Afione, Blake M. Warner, Masayuki Noguchi, Tatsuya Atsumi, John A. Chiorini
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Sjögren’s disease (SjD) is a chronic autoimmune sialadenitis resulting in salivary gland hypofunction with dry mouth symptom. Previous studies showed that lysosome-associated membrane protein 3 (LAMP3) overexpression is involved in the de
Externí odkaz:
https://doaj.org/article/44e1f0ed2ac2493291931e871aadc7d4
Autor:
Fabíola Reis de Oliveira, Ana Carolina F. Motta, Carolina Maria Módulo, Denny Marcos Garcia, John A. Chiorini, Paulo Louzada-Junior, Eduardo Melani Rocha
Publikováno v:
Advances in Rheumatology, Vol 62, Iss 1, Pp 1-13 (2022)
Abstract Background Sjögren Syndrome (SS) is a systemic autoimmune disease with a wide spectrum of manifestations that can lead to misdiagnosis. This study describes and compares demographic, clinical, serological, and histopathological data from su
Externí odkaz:
https://doaj.org/article/758ccc64a70d43619ced43925c1ea190
Autor:
Hiroyuki Nakamura, Tsutomu Tanaka, Youngmi Ji, Changyu Zheng, Sandra A Afione, Blake M Warner, Fabiola Reis Oliveira, Ana Carolina F Motta, Eduardo M Rocha, Masayuki Noguchi, Tatsuya Atsumi, John A Chiorini
Publikováno v:
PLoS ONE, Vol 18, Iss 2, p e0282227 (2023)
Hydroxychloroquine (HCQ) is a lysosomotropic agent that is commonly used for treating Sjögren's disease (SjD). However, its efficacy is controversial because of the divergent response to the drug among patients. In a subgroup of SjD patients, lysoso
Externí odkaz:
https://doaj.org/article/acc41cde337d44419ebc591577fb4021
Autor:
Jyoti Roy, Blake M. Warner, Falguni Basuli, Xiang Zhang, Changyu Zheng, Corrine Goldsmith, Tim Phelps, Karen Wong, Anita T. Ton, Rick Pieschl, Margaret E. White, Rolf Swenson, John A. Chiorini, Peter L. Choyke, Frank I. Lin
Publikováno v:
EJNMMI Research, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Background PSMA-targeted radionuclide therapy (TRT) is a promising treatment for prostate cancer (PCa), but dose-limiting xerostomia can severely limit its clinical adaptation, especially when using alpha-emitting radionuclides. With [18F]DC
Externí odkaz:
https://doaj.org/article/cca22949d8694e11bdc75a8355c78adb
Autor:
Giovanni Di Pasquale, Paola Perez Riveros, Muhibullah Tora, Tayyab Sheikh, Aran Son, Leyla Teos, Brigitte Grewe, William D. Swaim, Sandra Afione, Changyu Zheng, Shyh-Ing Jang, Akiko Shitara, Ilias Alevizos, Roberto Weigert, John A. Chiorini
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 19, Iss , Pp 459-466 (2020)
The loss of salivary gland function caused by radiation therapy of the head and neck or autoimmune disease such as Sjögren’s syndrome is a serious condition that affects a patient’s quality of life. Due to the combined exocrine and endocrine fun
Externí odkaz:
https://doaj.org/article/7be847276d9a4acbaec511e36b5c72eb
Autor:
Ying-Qian Mo, Hiroyuki Nakamura, Tsutomu Tanaka, Toshio Odani, Paola Perez, Youngmi Ji, Benjamin N. French, Thomas J.F. Pranzatelli, Drew G. Michael, Hongen Yin, Susan S. Chow, Maryam Khalaj, Sandra A. Afione, Changyu Zheng, Fabiola Reis Oliveira, Ana Carolina F. Motta, Alfredo Ribeiro-Silva, Eduardo M. Rocha, Cuong Q. Nguyen, Masayuki Noguchi, Tatsuya Atsumi, Blake M. Warner, John A. Chiorini
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 6 (2022)
BMP6 is a central cytokine in the induction of Sjögren’s syndrome–associated (SS-associated) secretory hypofunction. However, the upstream initiation leading to the production of this cytokine in SS is unknown. In this study, RNA ISH on salivary
Externí odkaz:
https://doaj.org/article/13dceb0a01ca49398b123ad81af78fba